GEO DataSets

(Submitter supplied) Human cytomegalovirus induces a pro-inflammatory monocyte following infection and we have evidence that NF-κB and phosphatidylinositol 3-kinase [PI(3)K] are key mediators in this early activation. To begin to address how these signalling pathways are responsible for the rapid activation of infected monocytes, we examined the role these pathways played in the transcriptome of infected monocytes. Global transcriptional profiling using cDNA microarrays revealed a significant number of genes, including inflammatory genes, were regulated in a NF-κB- and/or PI(3)K-dependent manner, identifying these pathways as key cellular control points in the conversion of monocytes to an activated pro-inflammatory state following HCMV infection. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3175

Platform:

GPL8300

12 Samples

Download data: CEL, CHP

Analysis of monocytes treated with an NF-kappaB or a phosphatidylinositol 3-kinase (PI3K) inhibitor and then infected with the human cytomegalovirus (HCMV). Results provide insight into the role of NF-kappaB and PI3K in the activation of monocytes to a proinflammatory state after an HCMV infection.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL8300

Series:

GSE9601

12 Samples

Download data: CEL, CHP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 27, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Based on this UniGene build and associated annotations, the HG-U95Av2 array represents approximately 10,000 full-length genes. more...

Organism:

Homo sapiens

99 DataSets

302 Series

6446 Samples

Download data