GSM1111214[Accession] - GEO DataSets

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Items: 4

Select item 2000456431.

Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes

(Submitter supplied) Progesterone and estrogen are important drivers of breast cancer proliferation. Herein, we probed estrogen receptor-α (ER) and progesterone receptor (PR) cross-talk in breast cancer models. Stable expression of PR-B in PR-low/ER+ MCF7 cells increased cellular sensitivity to estradiol and insulin-like growth factor 1 (IGF1), as measured in growth assays performed in the absence of exogenous progestin; similar results were obtained in PR-null/ER+ T47D cells stably expressing PR-B. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5621
Platform:: GPL10558
12 Samples

Download data: TXT

Series

Accession:: GSE45643

ID:: 200045643

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 56212.

Estradiol effect on MCF7 breast cancer cells expressing progesterone receptor-B

Analysis of estradiol-treated, progesterone receptor (PR)-low/estrogen receptor (ER)+ MCF7 breast cancer cells stably-expressing PR-B. Progesterone and estrogen are major drivers of breast cancer. Results provide insight into the molecular cross-talk between ER and PR-B in breast cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:: GPL10558
Series:: GSE45643
12 Samples

Download data

DataSet

Accession:: GDS5621

ID:: 5621

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000105583.

Illumina HumanHT-12 V4.0 expression beadchip

(Submitter supplied) The HumanHT-12 v4 Expression BeadChip provides high throughput processing of 12 samples per BeadChip without the need for expensive, specialized automation. The BeadChip is designed to support flexible usage across a wide-spectrum of experiments. The updated content on the HumanHT-12 v4 Expression BeadChips provides more biologically meaningful results through genome-wide transcriptional coverage of well-characterized genes, gene candidates, and splice variants. more...