GSM1186832[Accession] - GEO DataSets

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Items: 4

Select item 2000489211.

Gene expression and copy number analysis of OVCAR-3 and CDK2 resistant sublines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array; Expression profiling by array

Platforms:: GPL6244 GPL13135
20 Samples

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Series

Accession:: GSE48921

ID:: 200048921

Select item 2000489202.

Copy number analysis of OVCAR-3 and CDK2 resistant sublines

(Submitter supplied) Cyclin E1 (CCNE1) is amplified in various tumor types including high-grade serous ovarian cancer where it is associated with poor clinical outcome. We have demonstrate that suppression of the Cyclin E1 partner kinase, CDK2, induces apoptosis in a CCNE1 amplicon-dependent manner. Little is known of mechanisms of resistance to CDK inhibitors. We therefore generated OVCAR-3 sublines with reduced sensitivity to CDK2 inhibitors and profiled by SNP copy number microarrays.