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(Submitter supplied) Recent studies have been successful at utilizing ectopic expression of transcription factors to generate induced cardiomyocytes (iCMs) from fibroblasts, albeit at a low frequency in vitro. This work investigates the influence of small molecules that have been previously reported to improve differentiation to cardiomyocytes as well as reprogramming to iPSCs in conjunction with ectopic expression of the transcription factors Hand2, Nkx2.5, Gata4, Mef2C, and Tbx5 on the conversion to functional iCMs. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4898

Platform:

GPL6246

27 Samples

Download data: CEL, CHP

Analysis of embryonic fibroblasts and adult cardiac fibroblasts during conversion to induced cardiomyocytes (iCMs) in the presence of TGFβ inhibitor SB431542. SB increases the efficiency of iCM generation. Results provide insight into role of TGFβ signaling on conversion of fibroblasts to iCMs.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 agent, 2 cell type, 2 protocol sets

Platform:

GPL6246

Series:

GSE54022

27 Samples

Download data: CEL, CHP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Mus musculus

143 DataSets

2499 Series

28 Related Platforms

30153 Samples

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