GEO DataSets

(Submitter supplied) Burkitt lymphoma (BL) is a highly aggressive B cell non-Hodgkin lymphoma (B-NHL), which originates from germinal center (GC) B cells and harbors translocations deregulating the MYC oncogene. A comparative analysis of microRNAs (miRNAs) expressed in normal and malignant GC B cells identified miR-28 as significantly down-regulated in BL, as well as in other GC-derived B-NHL. We show that re-expression of miR-28 impairs cell growth and clonogenic properties of BL cells by modulating several targets including MAD2L1, a component of the spindle checkpoint whose down-regulation is essential in mediating miR-28-induced growth-arrest, and BAG1, an activator of the ERK pathway.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5298

Platform:

GPL570

24 Samples

Download data: CEL, CHP

Analysis of P3HR1 Burkitt lymphoma (BL) cells expressing miR-28 for 12 and 24 hours. BL is a highly aggressive B-cell non-Hodgkin lymphoma. miR-28 is downregulated in BL. Results provide insight into the role of miR-28 in the pathogenesis of BL.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol, 2 time sets

Platform:

GPL570

Series:

GSE56268

24 Samples

Download data: CEL, CHP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...

Organism:

Homo sapiens

602 DataSets

5668 Series

61 Related Platforms

174546 Samples

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