GSM1821454[Accession] - GEO DataSets

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Items: 3

Select item 2000708991.

Effect of IRE1a and XBP1 knockdown on gene expression in primary mouse keratinocytes expressing an HRas oncogene

(Submitter supplied) IRE1a is a critical modulator of the unfolded protein response. Its RNAse activity generates the mature transcript for the XBP1 transcription factor and also degrades other ER associated mRNAs in a process termed Regulated IRE1a Dependent mRNA Decay or RIDD. To determine if IRE1a is critical in the response to oncogenic Ras we used ShRNA to knockdown Ire1a or Xbp1 in primary mouse epidermal keratinocytes transduced with a v-HRAS retrovirus.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
12 Samples

Download data: CEL

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Accession:: GSE70899

ID:: 200070899

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000165702.

[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html Jan 30, 2013: annotation table updated with netaffx build 33 Protocol: See manufacturer's web site