GSM1967278[Accession] - GEO DataSets

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Items: 4

Select item 2000679471.

Dual RNA-seq – sRNA profiling in various cell types

(Submitter supplied) Bacteria possess many small noncoding RNAs whose regulatory roles in pathogenesis are little understood due to a paucity of macroscopic phenotypes in standard virulence assays. Here, we use a novel Dual RNA-seq approach for a single-step simultaneous RNA profiling in both pathogen and host to reveal molecular phenotypes of sRNAs during infection with Salmonella Typhimurium. We identify a new PhoP/Q-activated small RNA which upon bacterial internalization acts to temporally control the expression of both, invasion-associated effectors and virulence genes required for intracellular survival. more...

Organism:: Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344; Homo sapiens; Sus scrofa; Mus musculus

Type:: Expression profiling by high throughput sequencing

6 related Platforms
89 Samples

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Accession:: GSE67947

ID:: 200067947

PubMed Similar studies SRA Run Selector

Select item 2000601442.

Dual RNA-seq of diverse human, mouse and pig cell-types infected with various Salmonella strains

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344; Sus scrofa; Mus musculus; Salmonella enterica subsp. enterica serovar Typhimurium