GSM2471390[Accession] - GEO DataSets

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Items: 4

Select item 2000942371.

JAK inhibition in human CD8+ T-cells and C3H/HeJ Mice with Alopecia Areata In Vivo

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL19057
44 Samples

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Accession:: GSE94237

ID:: 200094237

PubMed Full text in PMC Similar studies

Select item 2000942362.

Effect of systemic exposure of JAK1 Inhibition (AZ13748709) in C3H/HeJ Mice with Alopecia Areata In Vivo

(Submitter supplied) JAK inhibition by means of clinically available pan JAK inhibitors has recently demonstrated great efficacy in both restoring hair growth and resolving inflammation in the skin of patients with Alopecia Areata (AA). These effects are dose dependent and mainly efficacious at ranges close to a questionable risk profile. Given the great responses to JAK inhibition and the current lack of efficacious treatments in AA, it is exciting to explore the possibilities to separate the beneficial and adverse effects in order to provide a successful treatment option for these patients where the medical need is still vastly unmet. more...