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Items: 3

1.

Reduced protein expression in a virus attenuated by codon deoptimization

(Submitter supplied) A general means of viral attenuation involves the extensive recoding of synonymous codons in the viral genome. The mechanistic underpinnings of this approach remain unclear, however. Using quantitative proteomics and RNA sequencing, we explore the molecular basis of attenuation in a strain of bacteriophage T7 whose major capsid gene was engineered to carry 182 suboptimal codons. We do not detect transcriptional effects from recoding. more...
Organism:
Escherichia coli
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21222
27 Samples
Download data: TSV
Series
Accession:
GSE96573
ID:
200096573
2.

Illumina NextSeq 500 (Escherichia coli)

Organism:
Escherichia coli
127 Series
2301 Samples
Download data
Platform
Accession:
GPL21222
ID:
100021222
3.

WT 5min rep7

Organism:
Escherichia coli
Source name:
cell culture
Platform:
GPL21222
Series:
GSE96573
Download data: TSV
Sample
Accession:
GSM2536129
ID:
302536129
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