GSM2988393[Accession] - GEO DataSets

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Items: 4

Select item 2001103541.

Accurate recycling of parental histones reproduces the histone modification landscape during DNA replication

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20301 GPL18573
57 Samples

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Series

Accession:: GSE110354

ID:: 200110354

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Select item 2001103522.

Accurate recycling of parental histones reproduces the histone modification landscape during DNA replication

(Submitter supplied) Chromatin organisation is disrupted genome wide during DNA replication. On newly synthesized DNA, nucleosomes are assembled from new naïve histones and old modified histones. It remains unknown whether the landscape of histone post-translational modifications (PTMs) is copied during DNA replication or the epigenomeis perturbed. Here we develop Chromatin Occupancy after Replication, ChOR-seq, a technology that combines chromatin immunopreciptation of histone marks and purification of newly replicated DNA by streptavidin pull-down followed by next generation sequencing. more...