GSM3168405[Accession] - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Search results

Items: 4

Select item 2001151621.

Regulation of Translation Elongation Revealed by Ribosome Profiling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Saccharomyces cerevisiae; Caenorhabditis elegans

Type:: Other

Platforms:: GPL16791 GPL18245 GPL17342
56 Samples

Download data: WIG

Series

Accession:: GSE115162

ID:: 200115162

PubMed Full text in PMC Similar studies

Select item 2001151612.

Regulation of Translation Elongation Revealed by Ribosome Profiling [Dataset_4]

(Submitter supplied) Ribosomes undergo substantial conformational changes during translation elongation to accommodate incoming aminoacyl-tRNAs and translocate along the mRNA template. We used multiple elongation inhibitors and chemical probing to define ribosome conformational states corresponding to different sized ribosome-protected mRNA fragments (RPFs) generated by ribosome profiling. We show using various genetic and environmental perturbations that the previously identified 20-22 nucleotide (nt) RPFs correspond predominantly to ribosomes in a pre-accommodation state with an open 40S ribosomal A site while the classical 27-29 nt fragments correspond to ribosomes in a pre-translocation state with an occupied 40S ribosomal A site. more...