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Items: 3

1.

Control of RNA pol II speed by PNUTS-PP1 and Spt5 dephosphorylation facilitates termination by a “sitting duck torpedo” mechanism

(Submitter supplied) Control of transcription speed, which influences many co-transcriptional processes, is poorly understood. We report that PNUTS-PP1 phosphatase is a negative regulator of RNA pol II elongation rate. The PNUTS W401A mutation, which disrupts PP1 binding, causes genome-wide acceleration of transcription associated with hyper-phosphorylation of the Spt5 elongation factor. Immediately downstream of poly(A) sites, pol II decelerates from >2kb/min to <1 kb/min, which correlates with Spt5 dephosphorylation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL24676 GPL16791
84 Samples
Download data: BW
Series
Accession:
GSE134198
ID:
200134198

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina NovaSeq 6000 (Homo sapiens)

Organism:
Homo sapiens
17080 Series
933677 Samples
Download data
Platform
Accession:
GPL24676
ID:
100024676

3.

293_pCW57_PNUTS_WT_Dox_DRB_10_PolII_Rep1

Organism:
Homo sapiens
Source name:
HEK293+pCW57 bla Avi-PNUTS WT
Platform:
GPL24676
Series:
GSE134198
Download data: BW
Sample
Accession:
GSM3938742
ID:
303938742

SRA Run Selector

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db=gds|term=GSM3938742[Accession]|query=1|qty=2|blobid=MCID_67353c35909f1e7b1309bc2b|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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