GEO DataSets

(Submitter supplied) NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated disproportionately to the cell cycle and cell proliferation (47/110, 43%) and more frequently than expected contained AU-rich, post-transcriptional regulatory elements (ARE). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1645

Platform:

GPL80

42 Samples

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Analysis of soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione. Cells treated in the presence of dibutyryl-cAMP (Bt2cAMP) to block signaling due to NO-induced decreases in cAMP. Results provide insight into the cGMP-independent effects of NO.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 5 agent, 2 development stage sets

Platform:

GPL80

Series:

GSE2649

42 Samples

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(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html Has 7129 entries and was indexed 29-Jan-2002. Probes represent approximately 5,000 full-length human sequences. Keywords = high density oligonucleotide array July 08, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site

Organism:

Homo sapiens

19 DataSets

57 Series

1490 Samples

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