GSM4299829[Accession] - GEO DataSets

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Items: 4

Select item 2001450921.

Intron looping is mediated by U1 snRNP and RNA polymerase II co-transcriptionally

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
18 Samples

Download data: BEDGRAPH, BW, TXT

Series

Accession:: GSE145092

ID:: 200145092

PubMed Full text in PMC Similar studies

Select item 2001448742.

Intron looping is mediated by U1 snRNP and RNA polymerase II co-transcriptionally [ChIP-seq]

(Submitter supplied) In the earliest step of spliceosome assembly, the two splice sites flanking an intron are brought into proximity by U1 snRNP and U2AF. The mechanism that facilitates this intron looping is poorly understood. Using a CRISPR interference-based approach to halt RNA polymerase II transcription in the middle of introns, we discovered that the 5 splice site base pairs with a U1 snRNA that is tethered to RNA polymerase II during intron synthesis. more...