GSM5261497[Accession] - GEO DataSets

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Items: 4

Select item 2001731781.

Discovery of pre-mRNA structural scaffold as a contributor to mammalian splicing code

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Human adenovirus 2

Type:: Other

Platform:: GPL30034
59 Samples

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Accession:: GSE173178

ID:: 200173178

PubMed Full text in PMC Similar studies

Select item 2001731752.

Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code [in vitro]

(Submitter supplied) The specific recognition of splice signals at or near exon-intron junctions is not explained by their weak conservation and instead is postulated to require a multitude of features embedded in the pre-mRNA strand. We explored the possibility of three-dimensional structural scaffold of AdML – a model pre-mRNA substrate – guiding early spliceosomal components to the splice signal sequences. We find that mutations in the non-cognate splice signal sequences impede recruitment of early spliceosomal components due to disruption of the global structure of the pre-mRNA. more...