GSM6509526[Accession] - GEO DataSets

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Items: 4

Select item 2002001871.

Circulating cell-free, methylated DNA reveals tissue-specific, cellular damage from radiation treatment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platforms:: GPL24676 GPL11154 GPL24247
87 Samples

Download data: BETA, CSI, PAT

Series

Accession:: GSE200187

ID:: 200200187

PubMed Full text in PMC Similar studies

Select item 2002000922.

Circulating cell-free, methylated DNA reveals tissue-specific, cellular damage from radiation treatment [Human Serum MCC-seq]

(Submitter supplied) Radiation therapy is an effective cancer treatment although damage to healthy tissues is common. Here we establish sequencing-based, cell-type specific DNA methylation reference maps of human and mouse tissues to infer the origins of cell-free DNA fragments released from dying cells into the circulation. We find cell-type specific DNA blocks mostly hypomethylated and located within genes intrinsic to cellular identity. more...