GSM722707[Accession] - GEO DataSets - NCBI

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Search results

Items: 4

Select item 2000292221.

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding [ChIP-Seq and DNAse-Hypersensitivity data]

(Submitter supplied) The t(8;21) translocation fuses the DNA binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a leukemia-initiating transcription factor that interferes with RUNX1 function. The result of this interference is a block in differentiation and, finally, the development of acute myeloid leukemia (AML). To obtain insights into RUNX1/ETO-dependant alterations of the epigenetic landscape we measured genome-wide RUNX1- and RUNX1/ETO bound regions in t(8;21) cells and assessed to what extent the effects of RUNX1/ETO on the epigenome depend on its continued expression in established leukemic cells. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
14 Samples

Download data: TXT

Series

Accession:: GSE29222

ID:: 200029222

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000292252.

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding

(Submitter supplied) The t(8;21) translocation fuses the DNA binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a leukemia-initiating transcription factor that interferes with RUNX1 function. The result of this interference is a block in differentiation and, finally, the development of acute myeloid leukemia (AML). To obtain insights into RUNX1/ETO-dependant alterations of the epigenetic landscape we measured genome-wide RUNX1- and RUNX1/ETO bound regions in t(8;21) cells and assessed to what extent the effects of RUNX1/ETO on the epigenome depend on its continued expression in established leukemic cells. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array; Methylation profiling by array

Platforms:: GPL9052 GPL10558
38 Samples

Download data: TXT

Series

Accession:: GSE29225

ID:: 200029225

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000090523.

Illumina Genome Analyzer (Homo sapiens)

Organism:: Homo sapiens

588 Series
7909 Samples

Platform

Accession:: GPL9052

ID:: 100009052

Select item 3007227074.

RUNX1ETO_siRE_ChIPSeq

Organism:: Homo sapiens

Source name:: Kasumi-1 transfection with RUNX1/ETO siRNA

Platform:: GPL9052
Series:: GSE29222 GSE29225

Download data: TXT

Sample

Accession:: GSM722707

ID:: 300722707

SRA Run Selector

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Supplemental Content

Filters: Manage Filters

Find related data

Search details

Important Links

Recent activity

Clear Turn Off Turn On

GSM722707[Accession] (4)
GEO DataSets

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Genes & Expression > Gene Expression Omnibus (GEO) Datasets