GSM973617[Accession] - GEO DataSets

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Items: 4

Select item 2000396441.

Amyotrophic lateral sclerosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL15846 GPL15847
48 Samples

Download data: TXT

Series

Accession:: GSE39644

ID:: 200039644

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000396432.

NanoString miRNA profiling of peripheral blood sorted CD14+CD16- monocytes from amyotrophic lateral sclerosis, multiple sclerosis and healthy control subjects

(Submitter supplied) We investigated the innate immune system in the SOD1 ALS model. We found that splenic Ly6CHi monocytes were activated and their progressive recruitment to the spinal cord, but not brain, correlated with neuronal loss. We found a decrease in resident microglia in the spinal cord with disease progression. Two months prior to disease onset, splenic Ly6CHi monocytes had an M1 signature which included increased CCR2. more...