GEO DataSets

Expression profiling of adrenal glands from blood pressure high (BPH) males at the prehypertensive stage. BPH males examined at 5 weeks of age. Results compared to gene expression in SHR rat model, and provides insight into mechanisms of hypertension shared across species.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 2 strain sets

Platform:

GPL81

Series:

GSE1674

6 Samples

Download data: CEL, EXP

(Submitter supplied) The objective of the experiment is to determine the genes differentially expressed in the adrenal gland of adult (12-week) BPH and BPL mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3777

Platform:

GPL81

6 Samples

Download data: CEL, CHP

(Submitter supplied) We measured gene expression in the adrenal glands of the Spontaneously Hypertensive Rat (SHR) and Wistar-Kyoto rat (WKY) using Affymetrix RG-U34A GeneChips. All rats were aged-matched at 4-weeks. The rats were obtained from the colonies at the Univeristy of California San Diego, La Jolla, CA. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1464

Platform:

GPL85

6 Samples

Download data: CEL, EXP

(Submitter supplied) We performed Affymetrix MG-U74Av2 GeneChip experiements on mRNA from the adrenal glands of the BPH hypertensive and BPL hypotensive mouse strains. All mice were aged-matched at 5 weeks. We obtained the mice from Jackson Laboratories, Bar Harbor, ME. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1011

Platform:

GPL81

6 Samples

Download data: CEL, EXP

Analysis of adrenal glands from genetically/hereditary hypertensive (BPH/2) and genetically/hereditary low-blood pressure (BPL/1) 12-week old adults. Results provide insight into molecular mechanisms underlying the pathogenesis of genetic hypertension.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL81

Series:

GSE19342

6 Samples

Download data: CEL, CHP

Comparison of adrenal gland from spontaneously hypertensive (SHR) males at 4 weeks of age, a prehypertensive stage, and normotensive Wistar-Kyoto. Results compared to gene expression in hypertensive BPH mouse model, and provides insight into mechanisms of hypertension shared across species.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL85

Series:

GSE1675

6 Samples

Download data: CEL, EXP

(Submitter supplied) Identification of hypothalamic genes whose expression differs between high blood pressure (BPH/2J) and normal blood pressure (BPN/3J) Schlager mouse strains at age 6 weeks (young) and 26 weeks (mature) using Affymetrix GeneChip® Mouse Gene 1.0 ST Arrays.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3895

Platform:

GPL6246

24 Samples

Download data: CEL

Analysis of hypothalamus from young (6 week-old) and adult (26 week-old) BPH/2J hypertensive males and age-/gender-matched normotensive BPN/3J controls. Results provide insight into molecular mechanisms underlying early and established neurogenic hypertension in hypothalamus.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 2 disease state, 2 strain sets

Platform:

GPL6246

Series:

GSE25076

24 Samples

Download data: CEL

(Submitter supplied) This study examined the renal gene expression profiles between spontaneously-hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats at a pre-hypertensive stage (3 weeks of age) and hypertensive stage (9 weeks of age). In addition, age-related changes in gene expression patterns were examined from 3 to 9 weeks in both WKY and SHR. Five to six individual kidney samples of the same experimental group were pooled together and quadruplicate hybridizations were performed on the NIEHS Rat v2.1, 2.2 and 3.0 arrays. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL1692 GPL1344 GPL1693

16 Samples

Download data

(Submitter supplied) Although the evidence for a genetic predisposition to human essential hypertension is compelling, the genetic control of blood pressure (BP) is poorly understood. The Dahl salt-sensitive (S) rat is a model for studying the genetic component of BP. Using this model we previously reported the identification of 16 different genomic regions that contain one or more BP quantitative trait loci (QTLs). The proximal region of rat chromosome 1 contains multiple BP QTLs. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL1350 GPL2796

19 Samples

Download data

(Submitter supplied) We examined gene expression profiles in the rat whole brains using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains: normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP). To identify candidate genes involved in the genesis of hypertension in the SHR strains, we compared the gene expression levels at 3 and 6 weeks of age, isolated 407 genes showing a more than 4-fold increase or a less than 1/4-fold decrease.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL14745

18 Samples

Download data: TXT

(Submitter supplied) Hypertension is a condition with major cardiovascular and renal complications, affecting nearly a billion patients worldwide. Few validated gene targets are available for pharmacological intervention, so there is a need to identify new biological pathways regulating blood pressure and containing novel targets for treatment. The genetically hypertensive “blood pressure high” (BPH), normotensive “blood pressure normal” (BPN), and hypotensive "blood pressure low" (BPL) inbred mouse strains are an ideal system to study differences in gene expression patterns that may represent such biological pathways. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3672 GDS3673 GDS3674 GDS3675

Platform:

GPL9734

67 Samples

Download data: CEL

Analysis of kidney of genetically hypotensive BPL, normotensive BPN, and hypertensive BPH inbred strains. Results provide insight into the molecular pathways affected by hypertension in the kidney.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL9734

Series:

GSE19817

14 Samples

Download data: CEL

Analysis of liver of genetically hypotensive BPL, normotensive BPN, and hypertensive BPH inbred strains. Results provide insight into the molecular pathways affected by hypertension in the liver.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL9734

Series:

GSE19817

15 Samples

Download data: CEL

Analysis of heart of genetically hypotensive BPL, normotensive BPN, and hypertensive BPH inbred strains. Results provide insight into the molecular pathways affected by hypertension in the heart.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL9734

Series:

GSE19817

15 Samples

Download data: CEL

Analysis of aorta of genetically hypotensive BPL, normotensive BPN, and hypertensive BPH inbred strains. Results provide insight into the molecular pathways affected by hypertension in the aorta.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL9734

Series:

GSE19817

23 Samples

Download data: CEL

(Submitter supplied) The development of hypertension may be highly influenced by the use of nicotine especially in genetically susceptible subjects. In this study the effects of nicotine on gene expression of cultured cells from the brainstem of spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats were evaluated using whole genome microarray platforms. It was described for the first time that nicotine may act differentially on the gene expression profile of SHR and WKY. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL2896

12 Samples

Download data: TXT

(Submitter supplied) Affymetrix RG U34A analysis of renal gene expression in Wistar-derived rat strains Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

55 Samples

Download data

(Submitter supplied) We examined gene expression profiles in the rat adrenal glands using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains: normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP). To identify candidate genes involved in the genesis of hypertension in the SHR strains, we compared the gene expression levels at 3 and 6 weeks of age, isolated 407 genes showing a more than 4-fold increase or a less than 1/4-fold decrease.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL14745

18 Samples

Download data: TXT

(Submitter supplied) Hypertension is a multifactor disease that possibly involves alterations in gene expression in hypertensive relative to normotensive subjects that are largely unknown. In this study we used high-density oligoarrays to compare gene expression profiles in cultured neurons and glia from pons and medulla oblongata of newborn spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats, a widely documented animal model of hypertension. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL2896

6 Samples

Download data: TXT