GEO DataSets

Analysis of plantaris muscle following a bout of voluntary running for 12 hours. Gene expression examined at various time points up to 24 hours following cessation of running. Results provide insight into molecular events occuring during the early phase of adaptation to endurance training.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 3 protocol, 5 time sets

Platform:

GPL254

Series:

GSE2001

7 Samples

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(Submitter supplied) To improve our understanding of the genetic reprogramming during the early phase of skeletal adaptation in response to endurance training, we employed cDNA microarray analysis to examine changes in mRNA expression in mouse plantaris muscle after a single bout voluntary running. Control untrained mice were compared with with R3h, R12h, P3h, P6h, P12h, P24h and R4w mice. We conclude that a single bout of voluntary running is sufficient to induce active remodeling processes, including cell proliferation, by a coordinated regulation of the genome in response to signals elicited from increased neuromuscular activity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1019

Platform:

GPL254

7 Samples

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(Submitter supplied) The 16K mouse cDNAs probes used in this microarray were designed using sequence information gathered from RIKEN FANTOM cDNA library. Probes can be 0.5 to 3 kb in length where about 60% of the probes represent full length transcripts. The PCR products were inkjet-printed on the array by Agilent Technologies (Palo Alto, CA).

Organism:

Mus musculus

35 DataSets

48 Series

641 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL5972

76 Samples

Download data: GPR

(Submitter supplied) Acute physical exercise elicits changes in gene expression in skeletal muscles to promote metabolic changes and to repair exercise-induced muscle injuries. Here, we investigated the impact of a single bout of running exercise until exhaustion on global transcriptional profiles in porcine skeletal muscles. Using a combined microarray and candidate gene approach, we identified a suite of genes that are differentially expressed in muscles during post-exercise recovery. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL5972

39 Samples

Download data: GPR

(Submitter supplied) Acute physical exercise elicits changes in gene expression in skeletal muscles to promote metabolic changes and to repair exercise-induced muscle injuries. Here, we investigated the impact of a single bout of running exercise until exhaustion on global transcriptional profiles in porcine skeletal muscles. Using a combined microarray and candidate gene approach, we identified a suite of genes that are differentially expressed in muscles during post-exercise recovery. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL5972

37 Samples

Download data: GPR

(Submitter supplied) Background: Muscle responses to exercise are complex, and potentially include acute responses to exercise-induced injury as well as longer-term adaptive training responses. Using Alaskan sled dogs as an experimental model, changes in muscle gene expression were analyzed to better understand the temporal changes that occur after severe exercise. Methods: Dogs were randomly assigned to undertake in a 160 km run (n=9), or to remain at rest (n=4). more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL6800

13 Samples

Download data: TXT

(Submitter supplied) The objective of this study was to understand the mechanisms behind the contribution of the alpha7BX2 integrin to improvements and growth in skeletal muscle post exercise. We utilized global gene profiling to identify novel signaling pathways and patterns of gene expression involved in this adaptation process, and found the alpha7BX2 integrin initiates transcription of genes that allow for protection from stress and modulation of protein synthesis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

24 Samples

Download data: TXT

(Submitter supplied) Regulated in DNA Damage and Development 1 (REDD1) is a stress induced protein whose expression is highly induced in skeletal muscle following a single bout of aerobic exercise. However, the role of this induction is unknown We used microarrays to detail the change in gene signature within skeletal muscle following a single bout of aerobic exercise in wild type and REDD1 null mice

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

12 Samples

Download data: CEL

(Submitter supplied) To undertake transcriptome-wide microarray analysis to develop a view of molecular adaptations that may underpin any benefit associated with the mild exercise regime of voluntary running

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

12 Samples

Download data: TXT

(Submitter supplied) Skeletal muscles are a diverse family of highly specialized tissues that perform a wide array of physiological activities and maintain whole-body glucose metabolism and energy homeostasis. Functional diversity is a distinctive feature of muscle tissues, which demonstrate remarkable variability in their speed of contraction, metabolic profile, resistance to fatigue, and regenerative capacity. Unsurprisingly, many disorders of skeletal muscle afflict a remarkably specific subset of tissues, including muscular dystrophies, cancer cachexia, aging sarcopenia, and amyotrophic lateral sclerosis. more...

Organism:

Mus musculus; Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL14844 GPL13112

126 Samples

Download data: BED, TXT

(Submitter supplied) We report that running at a young age showed ECM-related changes as well as angiogenesis-related pathways. Midlife running did not show this same affect.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

65 Samples

Download data: TXT