GEO DataSets

Expression profiling of lymphoblastoid cell lines from 15 CEPH/Utah families. Cell lines from 3 generations examined. Results provide insight into the heritability of gene expression traits in segregating human populations.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 15 specimen sets

Platform:

GPL564

Series:

GSE1726

167 Samples

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(Submitter supplied) Array data for "Genetic Inheritance of Gene Expression in Human Cell Lines" Monks, et al., American Journal of Human Genetics (2004) Keywords = Genetics of Gene Expression Keywords = human Keywords = CEPH family Keywords: repeat sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1048

Platform:

GPL564

167 Samples

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(Submitter supplied) Global gene expression information that can be used to identify pathways involved in the pathophysiology of disease. We used microarrays to identify which genes are expressed in either the abdominal aorta (control) or in abdominal aortic aneurysms (case), and also which genes may be differential between the two tissue states. Keywords: Characterization of expression in both diseased and non-diseased abdominal aortas.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2838

Platforms:

GPL2507 GPL570

19 Samples

Download data: TXT

Analysis of aneurysmal abdominal aortas (AAAs). Abdominal aortic aneurysms are a common disorder and mortality from ruptured AAAs is high. Results provide insight into the pathogenesis of abdominal aortic aneurysm.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 2 gender sets

Platform:

GPL570

Series:

GSE7084

4 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Triticum aestivum

Type:

Expression profiling by array

Platform:

GPL3802

76 Samples

Download data: CEL, EXP

(Submitter supplied) The use of statistical tools established for the genetic analysis of quantitative traits can be applied to gene expression data. Quantitative trait loci (QTL) analysis can associate expression of genes or groups of genes with particular genomic regions and thereby identify regions that play a role in the regulation of gene expression. A segregating population of 41 doubled haploid (DH) lines from the hard red spring wheat cross RL4452 x AC Domain was used. more...

Organism:

Triticum aestivum

Type:

Expression profiling by array

Platform:

GPL3802

72 Samples

Download data: CEL, EXP

(Submitter supplied) The use of statistical tools established for the genetic analysis of quantitative traits can be applied to gene expression data. Quantitative trait loci (QTL) analysis can associate expression of genes or groups of genes with particular genomic regions and thereby identify regions that play a role in the regulation of gene expression. A segregating population of 41 doubled haploid (DH) lines from the hard red spring wheat cross RL4452 x AC Domain was used. more...

Organism:

Triticum aestivum

Type:

Expression profiling by array

Platform:

GPL3802

4 Samples

Download data: CEL, EXP

(Submitter supplied) The use of statistical tools established for the genetic analysis of quantitative traits can be applied to gene expression data. Quantitative trait loci (QTL) analysis can associate expression of genes or groups of genes with particular genomic regions and thereby identify regions that play a role in the regulation of gene expression. A segregating population of 41 doubled haploid (DH) lines from the hard red spring wheat cross RL4452 x AC Domain was used. more...

Organism:

Triticum aestivum

Type:

Expression profiling by array

Platform:

GPL3802

78 Samples

Download data: CEL, EXP

(Submitter supplied) The use of statistical tools established for the genetic analysis of quantitative traits can be applied to gene expression data. Quantitative trait loci (QTL) analysis can associate expression of genes or groups of genes with particular genomic regions and thereby identify regions that play a role in the regulation of gene expression. A segregating population of 41 doubled haploid (DH) lines from the hard red spring wheat cross RL4452 x AC Domain was used. more...

Organism:

Triticum aestivum

Type:

Expression profiling by array

Platform:

GPL3802

4 Samples

Download data: CEL, EXP

(Submitter supplied) Gene expression is a complex quantitative trait partially regulated by genetic variation in DNA sequence. Population differences in gene expression could contribute to some of the observed differences in susceptibility to common diseases and responses to drug treatments. We characterize gene expression in the full set of HapMap lymphoblastoid cell lines derived from individuals of European and African ancestry for 9,156 transcript clusters (gene-level) evaluated using the Affymetrix GeneChip® Human Exon 1.0 ST Array. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

176 Samples

Download data: CEL, TXT

(Submitter supplied) This study was performed to identify transcripts that are differentially expressed in the mammary gland at 4 stages of developmental (virgin, pregnant, lactating and involution) in wild type C57BL/6J mice. Keywords: developmental stage

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2360

Platform:

GPL81

9 Samples

Download data: CEL

Analysis of whole mammary glands (no.4 inguinal) of C57BL/6J animals during puberty, pregnancy, lactation, and involution. Mammary glands examined during puberty were obtained from virgins.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 development stage sets

Platform:

GPL81

Series:

GSE5831

9 Samples

Download data: CEL

(Submitter supplied) Although the evidence for a genetic predisposition to human essential hypertension is compelling, the genetic control of blood pressure (BP) is poorly understood. The Dahl salt-sensitive (S) rat is a model for studying the genetic component of BP. Using this model we previously reported the identification of 16 different genomic regions that contain one or more BP quantitative trait loci (QTLs). The proximal region of rat chromosome 1 contains multiple BP QTLs. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL1350 GPL2796

19 Samples

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(Submitter supplied) We used high density oligonucleotide arrays to measure the relative expression levels of ~27,000 probe sets in the left ventricles of inbred rat strains; DA (high performing), Copenhagen (COP, low performing), as well as F1(COPxDA) rats bred from these two strains whose performance was intermediate relative to both parental strains. DA and COP rats differ for both intrinsic aerobic running capacity (assessed with a treadmill exercise test to exhaustion) and intrinsic cardiac performance (as assessed by the Langendorff-Neeley working heart model). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS778 GDS779 GDS780

Platforms:

GPL86 GPL87 GPL85

36 Samples

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Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 strain sets

Platform:

GPL87

Series:

GSE1795

12 Samples

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Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 strain sets

Platform:

GPL86

Series:

GSE1795

12 Samples

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Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 strain sets

Platform:

GPL85

Series:

GSE1795

12 Samples

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(Submitter supplied) Gene expression information is useful in prioritizing candidate genes in linkage intervals. The data can also identify pathways involved in the pathophysiology of disease. We used microarrays to identify which genes are expressed in either intracranial arteries (control) or in intracranial aneurysms (case), and can therefore contribute to the disease phenotypes. We used microarrays to identify the pathway membership of expressed genes and the overrepresentation of pathways with expressed genes in the known linkage intervals for intracranial aneurysms. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2507 GPL570

10 Samples

Download data: CEL, TXT

(Submitter supplied) Cisplatin, a platinating agent commonly used in treating several cancers is associated with nephrotoxicity, neurotoxicity and ototoxicity that have hindered its utility. To gain a better understanding of the genetic variants associated with cisplatin induced toxicity, we present a step-wise approach integrating genotypes, gene expression and sensitivity of HapMap cell lines to cisplatin. Cell lines derived from 30 trios of European descent (CEU) and 30 trios of African descent (YRI) were utilized to develop a preclinical model to identify genetic variants and gene expression that contribute to cisplatin induced cytotoxicity in two different populations. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

176 Samples

Download data: CEL, TXT

(Submitter supplied) Lymphoblastoid cell lines (LCLs), originally collected as renewable sources of DNA, are now being used as a model system to study genotype-phenotype relationships in human cells. These cell lines have been used to search for genetic variants that are associated with drug response as well as with more basic cellular traits such as RNA levels. In setting out to extend such studies by searching for genetic variants contributing to drug response, we observed that phenotypes in LCLs were, in our lab and others, significantly affected by experimental confounders (i.e. more...

Organism:

Homo sapiens; Pan troglodytes

Type:

Expression profiling by array

Platform:

GPL96

374 Samples

Download data: CEL