GEO DataSets

Expression profiling of male germ cells lacking the telomerase RNA component, Terc, or the DNA repair/telomere binding protein, Ku86, or both. Germ cells obtained from seminiferous tubules of 3 to 5 month old males. Results identify processes affected by dysfunctional telomeres.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 genotype/variation sets

Platform:

GPL81

Series:

GSE2498

8 Samples

Download data: CEL, CHP, EXP, RPT

(Submitter supplied) Transcriptome of murine testis from wild type mice and mice lacking telomerase for three generations (G3-Terc), Ku86 or both telomerase and Ku86. Keywords: ordered

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1248

Platform:

GPL81

8 Samples

Download data: CEL, CHP, EXP, RPT

(Submitter supplied) Somatic cell nuclear transfer (SCNT) and induced pluripotent stem cells (iPSCs) represent two major approaches for somatic cell reprogramming. However, little attention has been paid to the ability of these two strategies in rejuvenating cells from donors with aging associated syndrome. Here, we utilized telomerase deficient (Terc-/-) mice to probe this question. SCNT-derived embryonic stem cells (ntESCs) and iPSCs were successfully derived from second generation (G2) and third generation (G3) of Terc-/- mice, and ntESCs showed better differentiation potential and self-renewal ability. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

6 Samples

Download data: CEL

(Submitter supplied) Single-cell transcriptome analysis of 6-month Terc KO bone marrow and brain

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

2 Samples

Download data: MTX, TSV

(Submitter supplied) Single-cell transcriptome analysis of 1-month, 6-month, 20-month mouse bone marrow

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

3 Samples

Download data: MTX, TSV

(Submitter supplied) Single-cell transcriptome analysis of 1-month, 6-month, 20-month brain

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

3 Samples

Download data: MTX, TSV

(Submitter supplied) Single-cell transcriptome analysis of SARS-CoV-2 pseudovirus infection in cultured BMMs that are derived from 1-month and 18-month mice

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

2 Samples

Download data: MTX, TSV