GEO DataSets

Analysis of T-cell acute lymphoblastic leukemia (ALL) samples containing t(10;11)(p13;q14-21) translocation that fuses the clathrin-assembly protein-like lymphoid-myeloid leukemia gene CALM to the transcription factor AF10. Results provide insight into the consequences of CALM-AF10 expression.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 genotype/variation, 3 protocol, 2 tissue sets

Platform:

GPL96

Series:

GSE2117

23 Samples

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(Submitter supplied) Comparison of a series of 6 CALM-AF10 positive T-ALL to a series of 17 CALM-AF10 negative T-ALL Keywords: ordered

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1324

Platform:

GPL96

23 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; synthetic construct

Type:

Non-coding RNA profiling by array; Expression profiling by array

Platforms:

GPL6246 GPL8786

24 Samples

Download data: CEL

(Submitter supplied) The t(10;11) p (13;q14) translocation, giving rise to CALM-AF10, is a recurring chromosomal translocation observed in several types of acute leukemias as well as in lymphoma. We have previously demonstrated that the expression of the human CALM/AF10 fusion gene in murine bone marrow stem and progenitor cells results in an aggressive acute myeloid leukemia in vivo. In this study, we have screened the various domains essential for CALM-AF10 function and leukemogenicity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

12 Samples

Download data: CEL

(Submitter supplied) The t(10;11) p (13;q14) translocation, giving rise to CALM-AF10, is a recurring chromosomal translocation observed in several types of acute leukemias as well as in lymphoma. We have previously demonstrated that the expression of the human CALM/AF10 fusion gene in murine bone marrow stem and progenitor cells results in an aggressive acute myeloid leukemia in vivo. In this study, we have screened the various domains essential for CALM-AF10 function and leukemogenicity. more...

Organism:

synthetic construct; Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL8786

12 Samples

Download data: CEL

(Submitter supplied) The translocation t(10,11)(p13;q14) resulting in the formation of the CALM/AF10 fusion gene is involved in various hematological malignancies including acute myeloid leukemia, T-cell acute lymphoblastic leukemia, and malignant lymphoma and is usually associated with poor prognosis. We established a knock-in mouse model allowing tissue-specific CALM/AF10 expression from the Rosa26 locus using a loxP-STOP-loxP cassette to study leukemic transformation by the CALM/AF10 fusion protein during hematopoiesis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

23 Samples

Download data: CEL

(Submitter supplied) T-cell acute lymphoblastic leukemia (T-ALL) is mostly characterized by specific chromosomal abnormalities, some occurring in a mutually exclusive manner possibly delineating specific T-ALL subgroups. One subgroup, including MLL-rearranged, CALM-AF10 or inv(7)(p15q34) cases, is characterized by elevated expression of HOXA genes. Using a gene expression based clustering analysis of 67 T-ALL cases with recurrent molecular genetic abnormalities and 25 samples lacking apparent aberrations, we identified 5 new cases with elevated HOXA levels. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

92 Samples

Download data: CEL

(Submitter supplied) We report genomic occupancy of the AF10 PZP domain in MOLM13 cells

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL16791

1 Sample

Download data: BW

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL1261 GPL13112

68 Samples

Download data: CEL, WIG

(Submitter supplied) We used microarrays to investigate differential gene expression in HEK293T cells after transfection of the transgene of Iroquois 1 (IRX1). Microarray analysis revealed differential gene expression patterns of HEK293T cells after transient expression of IRX1. In total 8400 genes were deregulated by IRX1.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

2 Samples

Download data: CEL, CHP