GEO DataSets

Comparison of whole blood samples from 42 postmenopausal women on hormone replacement therapy (HRT) to those of 47 postmenopausal women not on HRT. Subjects are part of the Norwegian Women and Cancer Study (NOWAC).

Organism:

Homo sapiens

Type:

Expression profiling by array, log10 ratio, 2 protocol sets

Platform:

GPL887

Series:

GSE3492

89 Samples

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(Submitter supplied) The American Women’s Health Initiative study published in July 2002 caused considerable concern among hormone replacement therapy (HRT) users and prescribers in many countries. This study is an exploratory research comparing the genome wide expression profile in whole blood samples according to HRT use. Within the Norwegian Women and Cancer study, 100 postmenopausal women (50 HRT users and 50 non-HRT users) born between 1943 and 1949 with normal to high body mass index and no other medication use were selected. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1412

Platform:

GPL887

89 Samples

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(Submitter supplied) Modification of Gene Expression of Skeletal Muscle in Response to postmenopause with or without Hormone Replacement Therapy. Test samples randomly selected from a larger study in order to verify the validity of microarray experiment. Keywords: time course analysis from HRT users and non-users

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4590

5 Samples

Download data: TXT

(Submitter supplied) Modification of Gene Expression of Skeletal Muscle in Response to postmenopause with or without Hormone Replacement Therapy. Even though menopause is often accompanied with first signs of age-associated changes in muscle structure and function, the effects of hormone replacement therapy (HRT) or menopause-related decline in estrogen production in the muscles of postmenopausal women is not well understood. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3100

Platform:

GPL2700

30 Samples

Download data: TXT

Analysis of skeletal muscles of postmenopausal women treated with hormone replacement therapy (HRT) or with a placebo. Menopause is accompanied by age-associated changes in muscle structure and function. Results provide insight into the effect of HRT and estrogen deprivation on skeletal muscles.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 15 individual, 2 other, 2 protocol sets

Platform:

GPL2700

Series:

GSE6348

30 Samples

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(Submitter supplied) Analysis of gene expression profiles in skeletal muscle tissue after long-term use of HRT. Networks of enriched processes in skeletal muscle responding to long-term use of estrogen-based HRT in comparison with women without any HRT in a genetically controlled setting were contructed. The association between the expression of specific biological processes and muscle composition or performance was tested. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3855

Platform:

GPL6884

22 Samples

Download data: TXT

Analysis of skeletal muscle biopsies from monozygotic female twin pairs (55-62 years) discordant for estrogen-based, HRT (2-16 years). Results provide insight into molecular mechanisms underlying the beneficial effects of long-term HRT on skeletal muscle characteristics.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL6884

Series:

GSE21421

22 Samples

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(Submitter supplied) Using a large representative sample of postmenopausal women in the Norwegian Women and Cancer (NOWAC) postgenome study, we investigated blood gene expression changes due to intra-technical variability, normal inter-individuality (age, body mass index, fasting status), and exposure variables (smoking, hormone therapy and medication use) at proportion and level of real life situation revealing mechanistic insights of these effects mirrored in blood.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

286 Samples

Download data: TXT