GEO DataSets

(Submitter supplied) Although the evidence for a genetic predisposition to human essential hypertension is compelling, the genetic control of blood pressure (BP) is poorly understood. The Dahl salt-sensitive (S) rat is a model for studying the genetic component of BP. Using this model we previously reported the identification of 16 different genomic regions that contain one or more BP quantitative trait loci (QTLs). The proximal region of rat chromosome 1 contains multiple BP QTLs. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL1350 GPL2796

19 Samples

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(Submitter supplied) Male Dahl salt sensitive and Lewis rats (n=3 each) were fed an 8% NaCl diet starting at 5 weeks of age for 8 weeks. Total RNA was isolated with TRIzol reagent from DS and LEW kidneys and was subjected to microarray analysis. Keywords: animals with different genetic background comparison

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2710

Platform:

GPL1355

6 Samples

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Analysis of kidneys from Dahl salt-sensitive males fed a high salt diet. The Dahl salt sensitive animal is used as a model of hypertension. Results combined with quantitative trait loci analyses to identify candidate genes that influence blood pressure levels.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL1355

Series:

GSE4800

6 Samples

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(Submitter supplied) Kidney samples from three Dahl Salt-sensitive S rats were compared with kidney samples from three S.R(9)x3A congenic rats. Keywords = Blood Pressure Keywords = Quantitative trait locus Keywords = QTL Keywords = hypertension Keywords = rat Keywords = congenic Keywords: parallel sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS1545 GDS1546 GDS1547

Platforms:

GPL85 GPL86 GPL87

18 Samples

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Comparison of kidneys from a hypertensive salt-sensitive strain and a congenic salt-resistant strain, with much lower blood pressure (BP). Expression of genes located in the 2.4 cM BP quantitative trait locus (QTL) interval on chromosome 9 examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL87

Series:

GSE1775

6 Samples

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Comparison of kidneys from a hypertensive salt-sensitive strain and a congenic salt-resistant strain, with much lower blood pressure (BP). Expression of genes located in the 2.4 cM BP quantitative trait locus (QTL) interval on chromosome 9 examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL86

Series:

GSE1775

6 Samples

Download data

Comparison of kidneys from a hypertensive salt-sensitive strain and a congenic salt-resistant strain, with much lower blood pressure (BP). Expression of genes located in the 2.4 cM BP quantitative trait locus (QTL) interval on chromosome 9 examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL85

Series:

GSE1775

6 Samples

Download data

(Submitter supplied) We used high density oligonucleotide arrays to measure the relative expression levels of ~27,000 probe sets in the left ventricles of inbred rat strains; DA (high performing), Copenhagen (COP, low performing), as well as F1(COPxDA) rats bred from these two strains whose performance was intermediate relative to both parental strains. DA and COP rats differ for both intrinsic aerobic running capacity (assessed with a treadmill exercise test to exhaustion) and intrinsic cardiac performance (as assessed by the Langendorff-Neeley working heart model). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS778 GDS779 GDS780

Platforms:

GPL86 GPL87 GPL85

36 Samples

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Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 strain sets

Platform:

GPL87

Series:

GSE1795

12 Samples

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Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 strain sets

Platform:

GPL86

Series:

GSE1795

12 Samples

Download data

Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 strain sets

Platform:

GPL85

Series:

GSE1795

12 Samples

Download data

(Submitter supplied) Substitution of chromosome 13 from Brown Norway BN/SsNHsd/Mcw (BN/Mcw) rats into the Dahl salt-sensitive SS/JrHsd/Mcw (SS/Mcw) rats resulted in substantial reduction of blood pressure salt sensitivity in this consomic rat strain designated SSBN13. In the present study, we attempted to identify genes associated with salt-sensitive hypertension by utilizing a custom, known-gene cDNA microarray to compare the mRNA expression profiles in the renal medulla (a tissue playing a pivotal role in long-term blood pressure regulation) of SS/Mcw and SSBN13 rats on either low-salt (0.4% NaCl) or high-salt (4% NaCl, 2 wk) diets. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL3076

24 Samples

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(Submitter supplied) We measured gene expression in the adrenal glands of the Spontaneously Hypertensive Rat (SHR) and Wistar-Kyoto rat (WKY) using Affymetrix RG-U34A GeneChips. All rats were aged-matched at 4-weeks. The rats were obtained from the colonies at the Univeristy of California San Diego, La Jolla, CA. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1464

Platform:

GPL85

6 Samples

Download data: CEL, EXP

(Submitter supplied) We performed Affymetrix MG-U74Av2 GeneChip experiements on mRNA from the adrenal glands of the BPH hypertensive and BPL hypotensive mouse strains. All mice were aged-matched at 5 weeks. We obtained the mice from Jackson Laboratories, Bar Harbor, ME. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1011

Platform:

GPL81

6 Samples

Download data: CEL, EXP

Comparison of adrenal gland from spontaneously hypertensive (SHR) males at 4 weeks of age, a prehypertensive stage, and normotensive Wistar-Kyoto. Results compared to gene expression in hypertensive BPH mouse model, and provides insight into mechanisms of hypertension shared across species.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL85

Series:

GSE1675

6 Samples

Download data: CEL, EXP

Expression profiling of adrenal glands from blood pressure high (BPH) males at the prehypertensive stage. BPH males examined at 5 weeks of age. Results compared to gene expression in SHR rat model, and provides insight into mechanisms of hypertension shared across species.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 2 strain sets

Platform:

GPL81

Series:

GSE1674

6 Samples

Download data: CEL, EXP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Triticum aestivum

Type:

Expression profiling by array

Platform:

GPL3802

76 Samples

Download data: CEL, EXP

(Submitter supplied) The use of statistical tools established for the genetic analysis of quantitative traits can be applied to gene expression data. Quantitative trait loci (QTL) analysis can associate expression of genes or groups of genes with particular genomic regions and thereby identify regions that play a role in the regulation of gene expression. A segregating population of 41 doubled haploid (DH) lines from the hard red spring wheat cross RL4452 x AC Domain was used. more...

Organism:

Triticum aestivum

Type:

Expression profiling by array

Platform:

GPL3802

72 Samples

Download data: CEL, EXP

(Submitter supplied) The use of statistical tools established for the genetic analysis of quantitative traits can be applied to gene expression data. Quantitative trait loci (QTL) analysis can associate expression of genes or groups of genes with particular genomic regions and thereby identify regions that play a role in the regulation of gene expression. A segregating population of 41 doubled haploid (DH) lines from the hard red spring wheat cross RL4452 x AC Domain was used. more...

Organism:

Triticum aestivum

Type:

Expression profiling by array

Platform:

GPL3802

4 Samples

Download data: CEL, EXP

(Submitter supplied) The use of statistical tools established for the genetic analysis of quantitative traits can be applied to gene expression data. Quantitative trait loci (QTL) analysis can associate expression of genes or groups of genes with particular genomic regions and thereby identify regions that play a role in the regulation of gene expression. A segregating population of 41 doubled haploid (DH) lines from the hard red spring wheat cross RL4452 x AC Domain was used. more...

Organism:

Triticum aestivum

Type:

Expression profiling by array

Platform:

GPL3802

78 Samples

Download data: CEL, EXP