Similar studies for GEO DataSets (Select 200006710) - GEO DataSets

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Items: 20

Select item 2000067101.

Expression data from human skin biposies (lesional and uninvolved) from psoriatic patients

(Submitter supplied) Biopsies from uninvolved and from lesional skin of 13 patients with plaque-type psoriasis. Based on paired samples, 179 genes were more than 2-fold differentially expressed in lesional skin. Keywords: Comparison of uninvolved and lesional skin

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2518
Platform:: GPL96
26 Samples

Download data: CEL

Series

Accession:: GSE6710

ID:: 200006710

Select item 25182.

Psoriatic plaques

Analysis of uninvolved and lesional skin of 13 patients with plaque-type psoriasis. Psoriasis vulgaris is characterized by hyperproliferation and incomplete terminal differentiation of epidermal keratinocytes. Results provide insight into the molecular pathogenesis of psoriasis.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state, 13 individual sets

Platform:: GPL96
Series:: GSE6710
26 Samples

Download data: CEL

DataSet

Accession:: GDS2518

ID:: 2518

Select item 2000721403.

Transcriptional profiling shows altered expression of wnt pathway- and lipid metabolism-related genes as well as melanogenesis-related genes in melasma.

(Submitter supplied) Melasma is a commonly acquired hyperpigmentary disorder of the face, but its pathogenesis is poorly understood and its treatment remains challenging. We conducted a comparative histological study on lesional and perilesional normal skin to clarify the histological nature of melasma. Significantly, higher amounts of melanin and of melanogenesis-associated proteins were observed in the epidermis of lesional skin, and the mRNA level of tyrosinase-related protein 1 was higher in lesional skin, indicating regulation at the mRNA level. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
48 Samples

Download data: CEL

Series

Accession:: GSE72140

ID:: 200072140

Select item 2000608044.

Epigenetic silencing of SFRP4 contributes to epidermal hyperplasia in psoriasis

(Submitter supplied) To investigate the gene expression of imiquimod induced psoriasis-like mouse model, we have employed whole genome microarray as a discovery platform to identify genes differentially expressed compared with wild type C57BL6 mouse exposed to the vehicle of imiquimod.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
6 Samples

Download data: TXT

Series

Accession:: GSE60804

ID:: 200060804

Select item 2000164875.

Gene expression profiling of human mammary artery media during aging

(Submitter supplied) Our goal was to better understand the genes and pathways implicated during arterial media aging. We therefore compared the gene expression profile of human mammary artery media between Young (<60, 8 patients) and old (>75, 7 patients) patients. The microarray data, generated using the Illumina sentrix Ref8-V2 platform, was normalized and analyzed using the IlluminaGUI package (Eggle and Schultze, 2007).

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6104
15 Samples

Download data: TXT

Series

Accession:: GSE16487

ID:: 200016487

Select item 2000416646.

Comparison of Gene Expression in Psoriatic Skin from Different Sources

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
157 Samples

Download data: CEL

Series

Accession:: GSE41664

ID:: 200041664

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000416637.

Re-analysis by microarray using cDNA target of samples from psoriasis patients enrolled in an etanercept trial

(Submitter supplied) cDNA and cRNA hybridization technologies have different, probe-specific sensitivities. We used samples from an etanercept trial (GSE11903) to explore in a real-life setting the uniqueness of each platform.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
81 Samples

Download data: CEL

Series

Accession:: GSE41663

ID:: 200041663

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000416628.

Gene expression profiling in psoriatic lesional and non-lesional skin [Set 2]

(Submitter supplied) To explore the psoriasis phenotype and pathways involved in psoriasis, we characterized gene expression in lesional and non-lesional skin from psoriasis patients.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
48 Samples

Download data: CEL

Series

Accession:: GSE41662

ID:: 200041662

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000342489.

Gene expression profiling in psoriatic lesional and non-lesional skin [Set 1]

(Submitter supplied) To explore the psoriasis phenotype, we characterize gene expression in lesional and non-lesional skin from psoriasis patients.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
28 Samples

Download data: CEL

Series

Accession:: GSE34248

ID:: 200034248

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010787110.

RNA-seq identifies a diminished differentiation gene signature in primary monolayer keratinocytes grown from lesional and uninvolved psoriatic skin

(Submitter supplied) Keratinocyte (KC) hyper-proliferation and epidermal thickening are characteristic features of psoriasis lesions, but the specific contributions of KCs to plaque formation are not fully understood. This study used RNA-seq to investigate the transcriptome of primary monolayer KC cultures grown from lesional (PP) and non-lesional (PN) biopsies of psoriasis patients and control subjects (NN). Whole skin biopsies from the same subjects were evaluated concurrently. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10999
24 Samples

Download data: TXT

Series

Accession:: GSE107871

ID:: 200107871

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20003974311.

Stump project-- mRNA dermis; Volar versus non-volar acral skin gene expression

(Submitter supplied) We were interested in defining the gene signature of volar skin.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
12 Samples

Download data: CEL

Series

Accession:: GSE39743

ID:: 200039743

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003950012.

Stump project-- mRNA basal layer keratinocytes; Volar versus non-volar acral skin gene expression

(Submitter supplied) We were interested in defining the gene signature of volar skin.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
4 Samples

Download data: CEL

Series

Accession:: GSE39500

ID:: 200039500

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003926713.

Stump project -- mRNA epidermis; Volar versus non-volar acral skin gene expression

(Submitter supplied) We were interested in defining the gene signature of volar skin.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
12 Samples

Download data: CEL

Series

Accession:: GSE39267

ID:: 200039267

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003926614.

Stump project -- mRNA fibroblasts; Volar versus non-volar acral skin gene expression

(Submitter supplied) We were interested in defining the gene signature of volar skin.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
11 Samples

Download data: CEL

Series

Accession:: GSE39266

ID:: 200039266

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003913115.

Stump project -- methylation whole tissue; volar versus non-volar acral skin gene expression

(Submitter supplied) To broaden our understanding of the gene expression common to volar skin, we biopsied the dorsum of the hand, palm, dorsum of the foot and sole and collected DNA for methylation chip anlayses

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
12 Samples

Download data: TXT

Series

Accession:: GSE39131

ID:: 200039131

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003873216.

Stump project-- miRNA whole tissue; Volar versus non-volar acral skin gene expression

(Submitter supplied) To broaden our understanding of the gene expression common to volar skin, we biopsied the dorsum of the hand, palm, dorsum of the foot and sole and collected miRNA for chip anlayses

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL10850
16 Samples

Download data: TXT

Series

Accession:: GSE38732

ID:: 200038732

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003475617.

Stump project-- mRNA whole tissue; Volar versus non-volar acral skin gene expression

(Submitter supplied) We were interesed in defining the gene signautre of volar skin.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
16 Samples

Download data: CEL

Series

Accession:: GSE34756

ID:: 200034756

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010303818.

Genome-Wide DNA Methylation Profiling Identifies Differential Methylation in Uninvolved Psoriatic Epidermis

(Submitter supplied) The aim of the study was to investigate the differential methylation in psoriatic lesional epidermis compared to non-lesional or healthy epidermis.

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL18460
12 Samples

Download data: TXT

Series

Accession:: GSE103038

ID:: 200103038

PubMed Similar studies SRA Run Selector

Select item 20002686619.

Combined Use of Laser Capture Microdissection and Microarray Analysis Identifies Locally Expressed Disease-Related Genes in Focal Regions of Psoriasis Vulgaris Skin Lesions

(Submitter supplied) In this study, we sought to establish the usefulness of LCM on cDNA microarray analysis. We reported that LCM samples improved the sensitivity of detection of differentially expressed genes over conventional bulk tissue analysis. We also provided the new information of chemokine and its receptor interaction within psoriatic lesional skin.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
37 Samples

Download data: CEL

Series

Accession:: GSE26866

ID:: 200026866

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000273720.

Affected and unaffected skin of 4 psoriatic patients and normal skin of 3 psoriasis free individuals

(Submitter supplied) Gene expression profiling was performed on biopsies of affected and unaffected psoriatic skin and normal skin from seven Japanese patients to obtain insights into the pathways that control this disease. U95A Affymetrix DNA chips that contain oligonucleotide arrays of approximately 12,000 well-characterized human genes were used in the study. The statistical analysis of the Affymetrix data, based on the ranking of the Student-test statistic, revealed a complex regulation of molecular stress and immune gene responses. more...