GEO DataSets

(Submitter supplied) Recent studies demonstrated that tumor cells with stem cell-like properties can be cultured from human glioblastomas by using conditions that select for the expansion of neural stem cells. We established glioblastoma stem-like (GS-) cell cultures from 9 different glioblastomas, 8 of which generated stably expandable cell lines. Analyzing GS-cell cultures, we discovered two clearly discernable phenotypes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

17 Samples

Download data: CEL, EXP

(Submitter supplied) We compared a large panel of human glioblastoma stem-like (GS) cell lines, corresponding primary tumors and conventional glioma cell lines to identify cell lines that preserve the transcriptome of human glioblastomas most closely, thereby allowing identification of shared therapeutic targets. We used Affymetrix HG-U133 Plus 2.0 microarrays to compare human glioblastoma stem-like (GS) cell lines, corresponding primary tumors and conventional glioma cell lines.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3885

Platform:

GPL570

92 Samples

Download data: CEL, EXP

Analysis of glioblastoma stem-like (GS) cell lines, corresponding glioblastoma primary tumors, conventional glioma cell lines, and GS neurospheres. Results provide insight into cell lines recapitulating transcriptional aspects of glioblastomas, thereby allowing identification of therapeutic targets.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 7 specimen sets

Platform:

GPL570

Series:

GSE23806

92 Samples

Download data: CEL, EXP

(Submitter supplied) We cultured tumor cells from 22 GBM under medium conditions favoring the growth of neural stem cells. 11 out of 15 primary GBM contained a significant CD133+ subpopulation that comprised cells showing all hallmarks of neural stem cells. Cell lines derived from these CD133+ GBM showed a neurosphere-like, non-adherent growth pattern. In contrast, 4 out of 15 cell lines derived from primary GBM grew adherent in vitro and were driven by CD133- tumor cells that fulfilled stem cell criteria. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2728

Platform:

GPL570

6 Samples

Download data: CEL, CHP

Comparison of CD133+ and CD133- glioblastoma-derived cancer stem cells (CSC). Both CSC subpopulations were derived from primary glioblastomas. Results provide insight into the role of CD133+ and CD133- CSCs in the pathogenesis of glioblastoma.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 cell line sets

Platform:

GPL570

Series:

GSE7181

6 Samples

Download data: CEL, CHP

(Submitter supplied) Gene expression data of primary and secondary glioblastoma subgroups. Keywords: glioblastoma, transcription profiles

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

83 Samples

Download data

(Submitter supplied) Genomic abnormalities that are associated with mesecnhmal phenotype of GBM were detected in glioblastoma cell lines. Keywords: SNP array analysis of glioblastome cell lines.

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL1266

5 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

8 Samples

Download data: CEL

(Submitter supplied) To identify factors involved in tumorigenicity of glioma-initiating cells (GICs), we compared gene expression in GIC-like cells with and without sox11 expression.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

4 Samples

Download data: CEL

(Submitter supplied) To identify factors involved in glioma-initiating cells (GICs), we compared gene expression between GIC-like cells and non-GICs.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

4 Samples

Download data: CEL

(Submitter supplied) Our aim was to gain insight into the molecular pathways that distinguish pediatric- from adult-onset glioblastomas.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL9966

60 Samples

Download data: TXT

(Submitter supplied) Eighteen independent neurospheres derived from patients affected by primary glioblastoma were grouped into “classical”, “mesenchymal” or “proneural” subtypes according to analysis of genetic lesions and gene expression profiling. Here we show that expression of the MET oncogene, encoding the tyrosine kinase receptor for HGF, associates with mesenchymal and proneural neurospheres (Met-pos-NS). Met expression is almost absent from classical neurospheres (Met-neg-NS), and mutually exclusive with amplification and expression of the EGF receptor gene. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

37 Samples

Download data: TXT

(Submitter supplied) Glioblastoma, the most common and malignant brain tumor, harbors stem-like cells that self-renew and propagate upon serial transplantation. Although they share functional, morphological and developmental similarities to adult brain neural stem cells, stem cell characteristic pathways contributing to glioblastoma stem-like cells have not been consistently determined. Towards this goal we have provided an internally coherent molecular reference that compares adult neural and glioblastoma stem cells cultivated under identical conditions. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

14 Samples

Download data: TXT

(Submitter supplied) In this study, we explored the transcriptomic consequences of strong activation of the Notch pathway in embryonic human neural stem cells and in gliomas. For this we used a forced expression of the Notch intracellular domain (NICD). Glioblastoma multiforms (GBMs) are highly vascularized brain tumors containing a subpopulation of multipotent cancer stem cells. These cells closely interact with endothelial cells in neurovascular niches. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5671

Platform:

GPL11532

8 Samples

Download data: CEL, CHP

Analysis of Gb4 and Gb7 glioma cancer stem cells following forced expression of the Notch1 intracellular domain (NICD) to activate the Notch1 signaling pathway. Results provide insight into a role for the Notch1 pathway in glioblastoma stem cell plasticity and angiogenic properties.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 cell type, 2 genotype/variation sets

Platform:

GPL11532

Series:

GSE44561

8 Samples

Download data: CEL, CHP

(Submitter supplied) We established two novel glioma subclones those showed different invasive and angiogenic phenotypes. J3T-1 demonstrates robust angiogenesis and perivascular invasion. J3T-2 demonstrates diffuse invasion along white matter tracts. We used microarrays to show the difference of gene expression that contribute to the difference of phenotype.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

2 Samples

Download data: CEL

(Submitter supplied) High throughput sequencing of poly-A RNA

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15433

17 Samples

Download data: TXT

(Submitter supplied) Increasing evidence provide support that the mammalian liver contains stem/progenitor cells, but their molecular phenotype, embryological derivation, cell biology as well as of their role in the liver cell turnover and regeneration remain to be further clarified. We report the isolation, characterization and reproducible establishment in line of a resident liver stem cell (RLSC) with immunophenotype and differentiative potential distinct from other previously reported liver precursor/stem cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3520

Platform:

GPL1261

4 Samples

Download data: CEL, CHP

Analysis of the resident liver stem cell (RLSCs) lines MetE14/3 and WTE14/1. Results provide insight into the molecular phenotype of RLSCs.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 cell line, 2 cell type sets

Platform:

GPL1261

Series:

GSE7038

4 Samples

Download data: CEL, CHP

(Submitter supplied) Although a growing body of evidence indicates that the phenotypic plasticity exhibited by glioblastoma cells plays a central role in tumor development and post-therapy recurrence, the master drivers of their aggressiveness remain elusive. Here we mapped the changes in the transcriptionally permissive (H3K4me3) and repressive (H3K27me3) epigenetic histone marks accompanying the repression of glioblastoma stem cells (GSC) tumorigenicity. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL11154

6 Samples

Download data: BED