GEO DataSets

(Submitter supplied) To determine whether the polyamide-Chl conjugate 1R-Chl would cause similar changes in global gene expression in K562 cells, affymetrix gene chip analysis was performed using 1R-Chl. Through class comparison analysis, 1R-Chl affected the levels of transcription and genes of interest were determined. Keywords: Treatment response

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2970

Platform:

GPL570

6 Samples

Download data: CEL, CHP, EXP

Analysis of leukemia K562 cells treated with the polyamide-chlorambucil conjugate 1R-Chl. 1R-Chl down-regulates transcription of the human histone H4c gene and inhibits the growth of several cancer cell lines in vitro.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL570

Series:

GSE8832

6 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) SOX2 is a well-known transcription factor that plays a central role in maintaiing self renewal, pluripotency of embryonic stem cells, and cell fate determination during embryonic development. N-Methylpyrrole-N-methylimidazole polyamides (PIPs) are chemical compounds that can selectively recognize DNA sequence and achieve operative control over gene expression. In this study, the antitumor activity of a PIP targeting SOX2 binding sequence (SOX2i), which was recently shown to induce the targeted differentiation of stem cells into cardiomyocytes, was evaluated.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20844

2 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17077

13 Samples

Download data: TXT

(Submitter supplied) Amplification of MYCN plays a pivotal role in multiple types of tumors and correlates with poor prognosis in high-risk neuroblastoma. Despite recent advances in the treatment of neuroblastoma, no approaches directly target the master oncogene MYCN. Difficulties in targeting the MYCN protein have inspired us to develop a new gene level inhibitory strategy using a sequence-specific gene regulator. Here we generated a MYCN-targeting pyrrole-imidazole (PI) polyamide, MYCN-A3, which directly binds to and alkylates DNA at homing motifs within MYCN transcript. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17077

8 Samples

Download data: TXT

(Submitter supplied) Amplification of MYCN plays a pivotal role in multiple types of tumors and correlates with poor prognosis in high-risk neuroblastoma. Despite recent advances in the treatment of neuroblastoma, no approaches directly target the master oncogene MYCN. Difficulties in targeting the MYCN protein have inspired us to develop a new gene level inhibitory strategy using a sequence-specific gene regulator. Here we generated a MYCN-targeting pyrrole-imidazole (PI) polyamide, MYCN-A3, which directly binds to and alkylates DNA at homing motifs within MYCN transcript. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17077

5 Samples

Download data: TXT

(Submitter supplied) To investigate the effect of Ato-C on gene expression, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to suppress the cell proliferation of Ph+ CML cell lines. K562, KU-812 and MEG-A2 cells were treated with ATO, CDDP or Ato-C for 24 h in vitro.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

12 Samples

Download data: TXT

(Submitter supplied) LncRNA-IIRX plays critical role in Bcr-Abl-induced tumorigenesis. To discover its mechanisms underlying cellular transformation by Bcr-Abl oncogene, genome-wide mRNA expression was measured by RNA-seq in K562 cells expressing shRNA targeting lncRNA-IIRX and control cells. We identified many genes with differential expression in K562 cells after knocking down lncRNA-IIRX.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

6 Samples

Download data: TXT

(Submitter supplied) Aberrantly expressed long noncoding RNAs (lncRNAs) have been described in diverse human diseases and cancer development. Chronic myeloid leukemia (CML) is a hematological malignancy induced by Bcr-Abl hybrid gene. Owing to the development of tyrosine kinase inhibitors (TKIs), especially the first-generation Imatinib, over 90% of CML patients can be cured in recent years. Here we attempt to identify Imatinib-inducible lncRNAs associated with CML by analyzing lncRNA expression profiles in K562 cells after Imatinib or control treatment. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL21096

6 Samples

Download data: TXT, XLSX