GEO DataSets

(Submitter supplied) Background Alternative splicing is known to increase the complexity of mammalian transcriptomes since nearly all mammalian genes express multiple pre-mRNA isoforms. However, our knowledge of the extent and function of alternative splicing in early embryonic development is based mainly on a few isolated examples. High throughput technologies now allow us to study genome-wide alternative splicing during mouse development. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6096 GPL6193

50 Samples

Download data: CEL

(Submitter supplied) BACKGROUND: Breast cancer is the second most frequent type of cancer affecting women. We are increasingly aware that changes in mRNA splicing are associated with various characteristics of cancer. The most deadly aspect of cancer is metastasis, the process by which cancer spreads from the primary tumor to distant organs. However, little is known specifically about the involvement of alternative splicing in the formation of macroscopic metastases. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6193 GPL6096

24 Samples

Download data: CEL, TXT

(Submitter supplied) Background:Alternative splicing and isoform level expression profiling is an emerging field of interest within genomics. Splicing sensitive microarrays, with probes targeted to individual exons or exon-junctions, are becoming increasingly popular as a tool capable of both expression profiling and finer scale isoform detection. Despite their intuitive appeal, relatively little is known about the performance of such tools, particularly in comparison with more traditional 3’ targeted microarrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL5188 GPL5175

40 Samples

Download data: CEL

(Submitter supplied) Background:Alternative splicing and isoform level expression profiling is an emerging field of interest within genomics. Splicing sensitive microarrays, with probes targeted to individual exons or exon-junctions, are becoming increasingly popular as a tool capable of both expression profiling and finer scale isoform detection. Despite their intuitive appeal, relatively little is known about the performance of such tools, particularly in comparison with more traditional 3’ targeted microarrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5188

20 Samples

Download data: CEL

(Submitter supplied) Background:Alternative splicing and isoform level expression profiling is an emerging field of interest within genomics. Splicing sensitive microarrays, with probes targeted to individual exons or exon-junctions, are becoming increasingly popular as a tool capable of both expression profiling and finer scale isoform detection. Despite their intuitive appeal, relatively little is known about the performance of such tools, particularly in comparison with more traditional 3’ targeted microarrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

20 Samples

Download data: CEL

(Submitter supplied) This series represents 52 tissues hybridized across 5 different chip patterns. Probes were placed at every exon-exon junction in each transcript. Keywords = junction alternate splicing oligonucleotide Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS829 GDS830 GDS831 GDS832 GDS833

5 related Platforms

264 Samples

Download data

Monitoring of mRNA splice variants for more than 10,000 multi-exon genes using arrays with oligonucleotide probes positioned at exon-exon junctions. mRNA from 52 tissues and cell lines examined. Results provide tissue distribution of splice variants and identify novel splice variants.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 53 tissue sets

Platform:

GPL547

Series:

GSE740

54 Samples

Download data

Monitoring of mRNA splice variants for more than 10,000 multi-exon genes using arrays with oligonucleotide probes positioned at exon-exon junctions. mRNA from 52 tissues and cell lines examined. Results provide tissue distribution of splice variants and identify novel splice variants.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 51 tissue sets

Platform:

GPL546

Series:

GSE740

52 Samples

Download data

Monitoring of mRNA splice variants for more than 10,000 multi-exon genes using arrays with oligonucleotide probes positioned at exon-exon junctions. mRNA from 52 tissues and cell lines examined. Results provide tissue distribution of splice variants and identify novel splice variants.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 53 tissue sets

Platform:

GPL545

Series:

GSE740

54 Samples

Download data

Monitoring of mRNA splice variants for more than 10,000 multi-exon genes using arrays with oligonucleotide probes positioned at exon-exon junctions. mRNA from 52 tissues and cell lines examined. Results provide tissue distribution of splice variants and identify novel splice variants.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 49 tissue sets

Platform:

GPL544

Series:

GSE740

50 Samples

Download data

Monitoring of mRNA splice variants for more than 10,000 multi-exon genes using arrays with oligonucleotide probes positioned at exon-exon junctions. mRNA from 52 tissues and cell lines examined. Results provide tissue distribution of splice variants and identify novel splice variants.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 53 tissue sets

Platform:

GPL543

Series:

GSE740

54 Samples

Download data

(Submitter supplied) Through alternative processing of pre-mRNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an in-depth analysis of 15 diverse human tissue and cell line transcriptomes based on deep sequencing of cDNA fragments, yielding a digital inventory of gene and mRNA isoform expression. Analysis of mappings of sequence reads to exon-exon junctions indicated that ~94% of human genes undergo alternative splicing (AS), ~86% with a minor isoform frequency of 15% or more. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL9052

16 Samples

Download data: TXT

(Submitter supplied) Peripheral blood was collected from 18 Parkinson's Disease (PD) patients and 12 healthy controls (Ctrls). Total RNA was isolated and hybridized onto Affymetrix Exon_ST1 arrays to find in PDs versus controls: 1) genes that are differentiallly expressed and 2) genes with differential exonic expression (alternative splicing).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

28 Samples

Download data: CEL, TXT

(Submitter supplied) Manuscript Title: Discovery of tissue-specific exons using comprehensive human exon microarrays We have designed a high-density oligonucleotide microarray with probesets for more than one million annotated and predicted exons in the human genome. Using these arrays and a simple algorithm that normalizes exon signal to signal from the gene as a whole, we have identified tissue-specific exons from a panel of 16 different normal adult tissues. more...

Organism:

Homo sapiens

Type:

Expression profiling by genome tiling array

Platform:

GPL4253

48 Samples

Download data

(Submitter supplied) Using a quantitative alternative splicing (AS) microarray platform, we have identified a large number of widely-expressed mouse genes containing single or coordinated-pairs of alternative exons that are spliced in a tissue-regulated fashion. The majority of these AS events display differential regulation in central nervous system (CNS) tissues. Approximately half of the corresponding genes have neural-specific functions and operate in common processes and interconnected pathways. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL5370

27 Samples

Download data: TXT

(Submitter supplied) Alternative splicing microarray data in five normal tissues (brain, muscle, liver, bone marrow, testes) for 316 human genes. Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS909 GDS910

Platform:

GPL1704

19 Samples

Download data

Detection of tissue-specific regulation of alternative splicing for 316 genes in five normal tissues (brain, muscle, liver, bone marrow, testes) using array containing oligonucleotides spanning individual exons and splice junctions.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 5 tissue sets

Platform:

GPL1704

Series:

GSE1989

9 Samples

Download data

Detection of tissue-specific regulation of alternative splicing for 316 genes in five normal tissues (brain, muscle, liver, bone marrow, testes) using array containing oligonucleotides spanning individual exons and splice junctions.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 5 tissue sets

Platform:

GPL1704

Series:

GSE1989

10 Samples

Download data

(Submitter supplied) Human umbilical vein endothelial cells (HUVECs) were insulted with cobalt chloride to induce cell apoptosis and alternative splicing in the mimic-hypoxia environment. We use Affymetrix exon array to reveal differential expression from transcript-level and exon-level in genome-wide.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL5188 GPL5175

12 Samples

Download data: CEL

(Submitter supplied) We used RNA-seq to sequence the transcriptome of worms arrested in the first larval stage after hatching without food and starved for 12 hours, then a timecourse of animals recovering from arrest after feeding. We collected samples after 12 hours of starvation and 1, 3 and 6 hours after feeding.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL14752

10 Samples

Download data: BAM, BEDGRAPH, BW, GTF, TXT