GEO DataSets

(Submitter supplied) Purpose and Experimental Design: The purpose of this study is to find a methylation-related gene that could become a biomarker or therapeutic target in colorectal carcinoma (CRC). We screened candidate genes suspected to be silenced by DNA methylation using oligonucleotide microarray analysis. To investigate the clinical significance of one candidate gene (UNC5B), we analyzed the correlation between mRNA expression and clinicopathological features using clinical tissue samples. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

38 Samples

Download data: CEL

(Submitter supplied) Purpose: This study aimed to identify a novel biomarker or a target of treatment for colorectal cancer (CRC). Experimental Design: The expression profiles of cancer cells in 104 patients with CRC were examined using laser microdissection and oligonucleotide microarray analysis. Overexpression in CRC cells especially in patients with distant metastasis was a prerequisite to select candidate genes. The mRNA expression of candidate gene was investigated by quantitative reversetranscription polymerase chain reaction (RT-PCR) in 77 patients as a validation study. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4516 GDS4718

Platform:

GPL570

148 Samples

Download data: CEL

Analysis of homogenized colorectal cancer (CRC) tumors representing various stages and metastases. Results provide insight into predictive biomarkers of metastasis and treatment targets in CRC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state, 7 other sets

Platform:

GPL570

Series:

GSE21510

44 Samples

Download data: CEL

Analysis of LCM-isolated colorectal cancer (CRC) tumors representing various stages and metastases. Results provide insight into predictive biomarkers of metastasis and treatment targets in CRC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state, 7 other sets

Platform:

GPL570

Series:

GSE21510

104 Samples

Download data: CEL

(Submitter supplied) Methylation profiling in colorectal cancer : adjacent normal tissue vs colon tumor tissue

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL4126

24 Samples

Download data: TXT

(Submitter supplied) Distant metastasis is the major causes of death in colorectal cancer (CRC) patients. In order to identify genes influencing the prognosis of patients with CRC, we compared gene expression in primary tumors with and without distant metastasis using an oligonucleotide microarray. We also examined the expression of the candidate gene in 100 CRC patients by quantitative real-time reverse transcription PCR and studied the relationship between its expression and the prognosis of patients with CRC. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

111 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by SNP array

Platforms:

GPL3720 GPL570

297 Samples

Download data: CEL

(Submitter supplied) Introduction: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC). Experimental design: The expression profiles of cancer cells in 153 patients with CRC were examined using laser microdissection and oligonucleotide microarray analysis. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL3720

172 Samples

Download data

(Submitter supplied) Introduction: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC). Experimental design: The expression profiles of cancer cells in 153 patients with CRC were examined using laser microdissection and oligonucleotide microarray analysis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

125 Samples

Download data: CEL

(Submitter supplied) Microarray analyses for the identification of differences in gene expression patterns have increased our understanding of the molecular genetic events in colorectal cancer. We used gene expression analysis data from recurrent and non-recurrent patients with colorectal cancer to identify differentially expressed probes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

81 Samples

Download data: CEL

(Submitter supplied) Background: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC). Methods: The expression profiles of cancer cells in 152 patients with stage I-III CRC were examined using microarray analysis. High expression in CRC cells, especially in patients with distant recurrences, was a prerequisite to select candidate genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

152 Samples

Download data: CEL

(Submitter supplied) These colorectal cancer (CRC) samples have been analyzed by exon expression profiling to identify genes with overexpression of 3’ parts. By characterizing underlying transcript structures of such genes with a combination of rapid amplification of cDNA ends and deep-sequencing (RACE-seq), we identify and describe novel RNA-variants in CRC.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5188

77 Samples

Download data: CEL, CHP

(Submitter supplied) Multiple strategies are continuously being explored to expand the drug target repertoire in solid tumors. We devised a novel computational workflow for transcriptome-wide gene expression outlier analysis that allows the systematic identification of both overexpression and underexpression events in cancer cells. Here, it was applied to expression values obtained through RNA sequencing in 226 colorectal cancer (CRC) cell lines that were also characterized by whole-exome sequencing and microarray-based DNA methylation profiling. more...

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL21145

88 Samples

Download data: IDAT

(Submitter supplied) This array was performed to investigate the effect that colon fibroblasts have on gene expression in mouse tumor organoids.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23038

8 Samples

Download data: CEL

(Submitter supplied) The main goal of this study was to analyze transcriptional differences between AKP CRC organoids treated or not with chemotherapy (FOLFIRI) by RNA-seq.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

6 Samples

Download data: TXT

(Submitter supplied) We profiled CRC organoids engineered with different combinations of driver mutations. All organoids were derived from one mouse and then mutations were sequentially introduced by CRISPR Cas9

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21626

21 Samples

Download data: XLSX

(Submitter supplied) We sorted Emp1-tdTomato high and low cells from primary tumors grown in 4 different mice for 4 weeks

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23038

8 Samples

Download data: CEL