GEO DataSets

(Submitter supplied) Abstract: The mitochondrial electron transport chain is essential to Plasmodium and is the target of the antimalarial drug atovaquone. The mitochondrial genomes of Plasmodium sp. are the most reduced known, and the majority of mitochondrial proteins are encoded in the nucleus and imported into the mitochondrion post-translationally. Many organisms have signalling pathways between the mitochondria and the nucleus to regulate the expression of nuclear-encoded mitochondrially-targeted proteins, for example in response to mitochondrial dysfunction. more...

Organism:

Plasmodium falciparum; Anopheles gambiae

Type:

Expression profiling by array

Platform:

GPL1321

6 Samples

Download data: CEL

(Submitter supplied) Abstract: The antimalarial activity of the antibiotic thiostrepton has long been attributed to inhibition of apicoplast protein synthesis through binding of apicoplast ribosomal RNA. However, the kinetics of parasite death upon thiostrepton treatment differ from those seen for other inhibitors of apicoplast housekeeping functions. We have analysed global changes in gene expression of the malaria parasite, Plasmodium falciparum, in an attempt to shed light on the responses of the parasite to this drug. more...

Organism:

Plasmodium falciparum; Anopheles gambiae

Type:

Expression profiling by array

Dataset:

GDS4260

Platform:

GPL1321

6 Samples

Download data: CEL

Analysis of ring stage Plasmodium falciparum at 5 % parasitaemia treated with 2 uM thiostrepton, an antibiotic with antimalarial activity. Results provide insight into molecular mechanisms underlying parasite responses to the drug.

Organism:

Plasmodium falciparum; Anopheles gambiae

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL1321

Series:

GSE28701

6 Samples

Download data: CEL

(Submitter supplied) Transcriptional profiling of P. falciparum cultures treated with cyclohexylamine over time (18, 25 and 30 hours post invasion) A control experiment was also set up in which P. falciparum was not treated with cyclohexylamine, and samples were taken at 18, 25 and 30 h post invasion). Background Plasmodium falciparum, the causative agent of severe human malaria, has evolved to become resistant to previously successful antimalarial chemotherapies, most notably chloroquine and the antifolates. more...

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Platform:

GPL9109

18 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Arabidopsis thaliana

Type:

Expression profiling by array

Platform:

GPL13517

2 Samples

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(Submitter supplied) Plant mitochondria signal to the nucleus leading to altered transcription of nuclear genes by a process called mitochondrial retrograde regulation (MRR). MRR is implicated in metabolic homeostasis and responses to stress conditions. Transcriptional consequences on nuclear gene expression of mitochondrial perturbations were examined by a microarray analyses. Expression of 606 genes was altered by monofluoroacetate (MFA) inhibition of the TCA cycle in leaves of soil grown Arabidopsis plants in the dark for 10 hours. more...

Organism:

Arabidopsis thaliana

Type:

Expression profiling by array

Platform:

GPL13517

1 Sample

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(Submitter supplied) Plant mitochondria signal to the nucleus leading to altered transcription of nuclear genes by a process called mitochondrial retrograde regulation (MRR). MRR is implicated in metabolic homeostasis and responses to stress conditions. Transcriptional consequences on nuclear gene expression of mitochondrial perturbations were examined by a microarray analyses. Expression of 1316 was altered by antimycin A (AA) inhibition of the cytochrome respiratory pathway in leaves of soil grown Arabidopsis plants in the dark for 6 hours. more...

Organism:

Arabidopsis thaliana

Type:

Expression profiling by array

Platform:

GPL13517

1 Sample

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(Submitter supplied) Mutations in PfCRT confer chloroquine (CQ) resistance in P. falciparum. Point mutations in the homolog of the mammalian multidrug resistance gene (pfmdr1) can also modulate the levels of CQ response. However, parasites with the same pfcrt and pfmdr1 alleles exhibit a wide range of drug sensitivity, suggesting that additional genes contribute to levels of CQ resistance (CQR). We used 3 isogenic lines which have different drug resistance profiles corresponding to unique mutations in the pfcrt gene (106/1K76, 106/176I, and 106/76I-352K) to study changes in gene expression with and without CQ and genomic variations, i.e. more...

Organism:

Plasmodium falciparum; Anopheles gambiae

Type:

Expression profiling by array; Genome variation profiling by array

Dataset:

GDS3284

Platform:

GPL1321

24 Samples

Download data: CEL

Analysis of Plasmodium falciparum chloroquine-resistant transporter (PfCRT) mutants exposed to a low dose of chloroquine (CQ) for 3 h. The clones have different degrees of CQ resistance (CQR). Results provide insight into the molecular basis of the PfCRT effect on parasite susceptibility to CQ.

Organism:

Plasmodium falciparum; Anopheles gambiae

Type:

Expression profiling by array, transformed count, 2 agent, 3 genotype/variation sets

Platform:

GPL1321

Series:

GSE10022

18 Samples

Download data: CEL