GEO DataSets

(Submitter supplied) Interferon (IFN)-alpha causes high rates of depression and fatigue, and is used to investigate the impact of innate immune cytokines on brain and behavior. However, little is known about transcriptional profiles of circulating immune cells during chronic IFN-alpha administration. Accordingly, genome-wide transcriptional profiling was performed on peripheral blood mononuclear cells from 21 patients with chronic hepatitis C virus either awaiting IFN-alpha therapy (n=10) or after 12 weeks of IFN-alpha treatment (n=11). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

21 Samples

Download data: TXT

(Submitter supplied) Interferon alfa (IFN-alpha) is an approved therapeutic agent for chronic hepatitis C. To directly characterize the effects of IFN-alpha in humans, we used microarrays to profile gene expression in peripheral blood mononuclear cells (PBMCs) from hepatitis C patients treated with IFN-alpha. Seven patients were studied using two strategies: (1) in vivo: PBMCs were collected immediately before the first dose of IFN-alpha, and 3 and 6 hours after the dose; (2) ex vivo: PBMCs that were collected before the first IFN-alpha dose were incubated with IFN-alpha for 3 and 6 hours. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

4 related Platforms

46 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Third-party reanalysis

Platforms:

GPL570 GPL6244

18 Samples

Download data: CEL

(Submitter supplied) Approximately 50% of patients with chronic hepatitis C (CHC) have a sustained virologic response (SVR) to treatment with pegylated interferon (pegINF)-α and ribavirin. Non-response to treatment is associated with constitutively increased expression of IFN-stimulated genes (ISGs) in the liver. Treatment of patients with acute hepatitis C (AHC) is more effective, with SVR rates >90%. We investigated mechanisms of the different responses of patients with CHC and AHC to pegIFN-α therapy. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Third-party reanalysis

Platform:

GPL570

8 Samples

Download data: CEL, TXT

(Submitter supplied) Approximately 50% of patients with chronic hepatitis C (CHC) have a sustained virologic response (SVR) to treatment with pegylated interferon (pegINF)-α and ribavirin. Non-response to treatment is associated with constitutively increased expression of IFN-stimulated genes (ISGs) in the liver. Treatment of patients with acute hepatitis C (AHC) is more effective, with SVR rates >90%. We investigated mechanisms of the different responses of patients with CHC and AHC to pegIFN-α therapy. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

10 Samples

Download data: CEL

(Submitter supplied) Time series of gene expression arrays before and during treatment of Hepatitis C; days 0, 1, 2, 7, 14 and 28 for 69 participants (IDs 1 through 69 are used). Treating chronic hepatitis C using peginterferon alpha and ribavirin leads to sustained clearance of virus and clinical improvement in approximately 50% of patients. Response rates are lower among patients with genotype 1 than with genotypes 2 and 3 and among African American ( AA) compared to Caucasian (CA) patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

397 Samples

Download data: CEL, TXT

(Submitter supplied) The research hypothesis was that the unique expression profile of monocytes in response to Interferon-beta (IFN-β) might be masked by the response profile of the more abundant T cells. The analysis of monocytes response may highlight novel IFN-β functions and pathways that have not been recognized previously. The aim of this study was to characterized the IFN-β transcriptional response in monocytes, a small but influential cell-subset, using gene expression profile and pathway analysis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6884

12 Samples

Download data: TXT

(Submitter supplied) Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of social isolation. Keywords: Risk prediction

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3207

Platform:

GPL96

14 Samples

Download data: CEL

Analysis of leukocytes from individuals experiencing chronically high levels of subjective social isolation (loneliness). Social environment is known to influence human health. Results provide insight into transcriptional alterations in the immune system induced by chronic social isolation.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 individual sets

Platform:

GPL96

Series:

GSE7148

14 Samples

Download data: CEL

(Submitter supplied) Interferon-alpha is a major therapeutic agent for many diverse diseases. However, the interferon-alpha mechanism of therapeutic action and associated side effects are not well understood. In particular, thyroiditis is a common unexplained complication. We hypothesized that direct thyroid-toxic actions coupled with immune mechanisms play a major role in the thyroiditis etiology. To test this hypothesis, we investigated the actions of interferon-alpha on cultured thyrocytes in vitro, and in vivo by creating transgenic mice overexpressing interferon-alpha tissue specifically in thyrocytes. more...

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL10999 GPL11002

5 Samples

Download data: BED, TXT

(Submitter supplied) Transcriptome profiling was conducted on 2 replicate samples of total peripheral blood mononuclear cells (PBMC) and isolated PBMC subsets.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10904

23 Samples

Download data: TXT

(Submitter supplied) Comparison of transcript abundance estimates and bioinformatic inferences derived from DBS vs PAXgene vs peripheral blood mononuclear cell (PBMC) samples.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10904

249 Samples

Download data: TXT

(Submitter supplied) Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 53 female breast cancer patients at 6- or 12-month follow-ups in a randomized controlled trial of Cognitive Behavioral Stress Management or an active control condition. The primary research question is whether gene expression differs in patients treated with Cogntive Behavioral Stress Management vs control conditions.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10904

53 Samples

Download data: TXT

(Submitter supplied) Individual differences in basal leukocyte gene expression profiles as a function of hedonic and eudaimonic well-being.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10904

79 Samples

Download data: TXT

(Submitter supplied) Quantifying impact of lead on cytokine production and gene expression in PBMCs

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

102 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 4 mo old rhesus macaques subject to maternal rearing, peer rearing, or surrogate peer rearing. The primary research question is whether gene expression differs as a function of early rearing conditions.

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

13 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 93 older adults participating in the Chicago Health Aging and Social Relations Study (CHASRS). The primary research question is whether gene expression differs in participants who are chronically lonely. Keywords: Risk prediction

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3898

Platform:

GPL6883

93 Samples

Download data: TXT

Analysis of PBMCs from chronically lonely, older adults. Lack of close social ties is a well-established risk factor for diseases involving the immune system and inflammation. Results provide insight into the molecular mechanisms underlying those effects.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 individual sets

Platform:

GPL6883

Series:

GSE25837

93 Samples

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(Submitter supplied) We report scRNA-seq of in vitro morphine treated PBMCs reveals suppression of anti-viral genes in various immune cell types.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

2 Samples

Download data: CSV, TXT