Similar studies for GEO DataSets (Select 200034925) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2000349251.

Expression data from knockdown of G9a in MDA-MB231 cells

(Submitter supplied) G9a is an H3K9m2 methyltransferase, which is critical in controlling gene suppression and DNA methylation. We used microarray analysis to identify the target genes that are regulated by G9a in MDA-MB231 cells, in which E-cadherin is silenced.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4800
Platform:: GPL6244
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE34925

ID:: 200034925

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 48002.

H3K9me2 methyltransferase G9a depletion effect on breast cancer cell line

Analysis of MDA-MB231 breast cancer cells depleted for G9a, a methyltransferase that mediates histone H3 lysine-9 di-methylation (H3K9me2). G9a depletion inhibits migratory ability and invasiveness of MDA-MB231 cells. Results provide insight into role of G9a and H3K9me2 in breast cancer progression.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL6244
Series:: GSE34925
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4800

ID:: 4800

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000603243.

Effect of knock down of LASP-1 on human breast cancer cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL16686 GPL6244
12 Samples

Download data: CEL

Series

Accession:: GSE60324

ID:: 200060324

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000603234.

Effect of knock down of LASP-1 on basal-like breast cancer cells (MDA-MB-231)

(Submitter supplied) Nuclear LASP-1 has a direct correlation with the overall survival of breast cancer patients. Gene expression analysis of MDA-MB-231S (sorted for high surface expression of CXCR4) and MDA-Bone-Un (Mouse bone metastasized MDA-MB-231 cells) human basal-like breast cancer cells cultured in 3D-Matrigel was performed. Changes in transcript levels of key microRNAs 29B1 and 29B2, miRLet7F1, miR519A1, MMP9, MMP1, FAM75D4, Interferons a7 and a17, Glycine receptor a3, CADM2 and claudin12

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
4 Samples

Download data: CEL, TXT

Series

Accession:: GSE60323

ID:: 200060323

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000603225.

Effect of knock down of LASP-1 on luminal breast cancer cells (MCF7)

(Submitter supplied) Nuclear LASP-1 has a direct correlation with the overall survival of breast cancer patients. Gene expression analysis of MCF7 human breast cancer cells cultured in 3D-Matrigel was performed. Up regulation of cell junction proteins, extracellular matrix proteins and down regulation of MMP 9 and 2 were observed. This corroborates well with the involvement of LASP-1 in cell migration and chemotaxis.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
8 Samples

Download data: CEL, TXT

Series

Accession:: GSE60322

ID:: 200060322

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000594496.

Expression data from MCF7 breast epithelial cells in normoxic and hypoxic conditions.

(Submitter supplied) G9a is able to silence gene expression in hypoxic condition by increasing histone H3K9me2. We have identified a set of genes that are negatively regulated by G9a in hypoxia-dependent manner. In this dataset, we include the expression data obtained from MCF7 breast epithelial cells that have been transfected with control (WT) or G9a shRNAs (KD) and exposed to either normoxia or hypoxia. These data are used to obtain 829 genes that are differentially expressed in response to hypoxia, and 205 genes that are sentisive to G9a level.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
4 Samples

Download data: CEL

Series

Accession:: GSE59449

ID:: 200059449

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001525467.

Effect of NSD3 on MDA-MB-231 breast cancer cells (RNA-seq)

(Submitter supplied) RNA-sequencing analysis of control (shCon) and NSD3-knockdown (shNSD3) MDA-MB-231 cell lines. NSD3 (also known as WHSC1L1), a histone H3 lysine K36methyltransferase, is highly amplificated in several human cancers, including breast carcinomas. Results provide insight into the transcriptional regulation of NSD3 in breast cancer.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: TXT

Series

Accession:: GSE152546

ID:: 200152546

Select item 2000626168.

G9a, ZNF644 and WIZ ChIP-seq results

(Submitter supplied) The G9a mediates mono- and dimethylation of Lys9 of histone H3 at specific gene loci, which is associated with transcriptional repression. ZNF644 and WIZ contain multiple zinc finger motifs that recognize consensus DNA sequences.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
4 Samples

Download data: BED

Series

Accession:: GSE62616

ID:: 200062616

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000765079.

G9a-Mediated Methylation of ERα Links the PHF20/MOF Histone Acetyltransferase Complex to Hormonal Gene Expression

(Submitter supplied) The euchromatin histone methyltransferase 2 (EHMT2, aka G9a) methylates histone H3K9 to repress gene expression, but it also acts as a coactivator for some nuclear receptors. The molecular mechanisms underlying this activation remain elusive. Here we show that G9a functions as a bona fide coactivator of the endogenous estrogen receptor α (ERα) in breast cancer cells in a histone methylation-independent manner. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
12 Samples

Download data: TXT

Series

Accession:: GSE76507

ID:: 200076507

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20000767410.

G9a histone methyltransferase maintains genomic imprinting in the mouse placenta.

(Submitter supplied) Whereas DNA methylation is essential for genomic imprinting, the importance of histone methylation in the allelic repression of imprinted genes is unclear. ‘Imprinting control regions’ (ICRs), however, are consistently marked by histone H3 K9 methylation on their DNA-methylated allele. In the placenta, the paternal silencing along the Kcnq1 domain on distal chromosome 7 also correlates with the presence of H3-K9 methylation, but imprinted repression at these genes is maintained independently of DNA methylation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL339 GPL1261 GPL340
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE7674

ID:: 200007674

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011534111.

Expression data from bladder cancer cells T24 - treated with G9a siRNA or negative control siRNA

(Submitter supplied) Target genes regulated by G9a in bladder cancer cells T24 In this dataset, we include the expression data obtained from bladder cancer cells T24 treated with G9a siRNA or negative control siRNA. These data are used to obtain genes that are differentially expressed in response to G9a konckdown.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23159
6 Samples

Download data: CEL

Series

Accession:: GSE115341

ID:: 200115341

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012585012.

Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease

(Submitter supplied) Epigenetic dysregulation, which leads to the alteration of gene expression in the brain, is suggested as one of the key pathophysiological bases of aging and neurodegeneration. Here we found that, in the late-stage familial Alzheimer’s disease (FAD) mouse model, repressive histone H3 dimethylation at lysine 9 (H3K9Me2) and euchromatic histone methyltransferases, EHMT1 and EHMT2 (H3K9Me2 catalyzer), were significantly elevated in the prefrontal cortex (PFC) region of post-mortem tissues from human patients with Alzheimer's disease. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TSV, TXT

Series

Accession:: GSE125850

ID:: 200125850

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011637013.

Transcriptome profile of breast cancer HS-578T cells overexpressing EP300

(Submitter supplied) HS-578T cells overexpressing EP300 show an increase in doxorubicin and paclitaxel resistance, up-regulation of EMT markers together with an increase in motility and invasion, and an increase in the percentage of cancer stem cells and mammosphere formation.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23159
6 Samples

Download data: CEL

Series

Accession:: GSE116370

ID:: 200116370

Select item 20005151214.

Gene expression profiling of BIX01294-treated human neuroblastoma cell line BE(2)-C

(Submitter supplied) Increased activation of the serine-glycine biosynthetic pathway is an integral part of cancer metabolism that drives macromolecule synthesis needed for cell proliferation. Whether this pathway is under epigenetic control is unknown. Here we show that the histone H3 lysine 9 (H3K9) methyltransferase G9A is required for maintaining the pathway enzyme genes in an active state marked by H3K9 monomethylation and for the transcriptional activation of this pathway in response to serine deprivation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
6 Samples

Download data: CEL

Series

Accession:: GSE51512

ID:: 200051512

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20017923415.

SPOP mutations derived from prostate cancer establish a DNA hypermethylation epigenome through stabilizing GLP histone methyltransferase [methylation array]

(Submitter supplied) Abnormal DNA methylation is one of the major factors driving oncogenesis and therapy resistance in cancer. The CULLIN3-RBX1 E3 ubiquitin ligase adaptor gene SPOP is the most frequently mutated gene in primary prostate cancers (PCa). SPOP-mutated prostate tumors strikingly associate with strongly elevated levels of genome-wide DNA hypermethylation, although the underlying mechanism remains elusive.We use Illumina Infinium MethylationEPIC BeadChip to depict DNA methylation in control and SPOP F102C stabily expressed 22Rv1 cells. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL23976
8 Samples

Download data: IDAT, TSV

Series

Accession:: GSE179234

ID:: 200179234

PubMed Full text in PMC Similar studies

Select item 20015549116.

SPOP mutations derived from prostate cancer establish a DNA hypermethylation epigenome through stabilizing GLP histone methyltransferase

(Submitter supplied) Abnormal DNA methylation is one of the major factors driving oncogenesis and therapy resistance in cancer. The CULLIN3-RBX1 E3 ubiquitin ligase adaptor gene SPOP is the most frequently mutated gene in primary prostate cancers (PCa). SPOP-mutated prostate tumors strikingly associate with strongly elevated levels of genome-wide DNA hypermethylation, although the underlying mechanism remains elusive. We use reduced representation bisulfite sequencing (RRBS) to depict DNA methylation in control and SPOP F133V stably expressed 22Rv1 cells. more...

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL20301
4 Samples

Download data: TXT

Series

Accession:: GSE155491

ID:: 200155491

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002604017.

Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks

(Submitter supplied) Analysis of cross talk of epigenetic marks in HBEC by using tilling arrays chr19. In Human Bronchial epithelia cells (HBEC), H3K9me3, H4K20me3, H3K4me3, H3K27me3, H3K36me3 and DNA methylation were profiled. In these cells, DNA methylation status was analyzed by MIRA and UnmethylCollector (UMC). Study of epigenetic changes in HCT116 DNMT1-/- and DNMT3b -/- (HCT116-DKO) in comparison to intact HCT116. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array; Methylation profiling by genome tiling array

Platform:: GPL11313
17 Samples

Download data: GFF, PAIR

Series

Accession:: GSE26040

ID:: 200026040

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002603818.

Crosstalk between gene body DNA methylation, H3K9me3 and H3K36me3 chromatin marks and transcription [HuEx-1_0-st, transcript]

(Submitter supplied) This is one of expressional parts of the study. These data were correlated to epigenetic marks and CG density of genes in analyzed cells. The whole study has a following summary: To elucidate possible roles of DNA methylation and chromatin marks in transcription, we performed epigenetic profiling of chromosome 19 in human bronchial epithelial cells (HBEC) and in the colorectal cancer cell line HCT116 as well as its counterpart with double knockout of DNMT1 and DNMT3B (HCT116-DKO). more...