GEO DataSets

(Submitter supplied) Over the past decade, considerable progress has been made regarding the discovery of gene targets by nanobiotechnologies. However, a huge gap frequently exists between candidate and therapeutic relevant genes due to the limitations associated with functional analyses. We report herein on the use of an integrated technologies involving a DNA microarray and an in vivo siRNA delivery system to rapidly and efficiently discover gene targets. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

8 Samples

Download data: TXT

(Submitter supplied) Abnormalities in hepatic lipid metabolism are believed to play a critical role in the etiology of nonalcoholic steatohepatitis (NASH). Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol to diacylglycerol, which is the penultimate step in one pathway for triacylglycerol (TAG) synthesis. Hepatic expression of Mogat1, which encodes an MGAT enzyme, is increased in the livers of mice with hepatic steatosis and knocking down Mogat1 improves insulin sensitivity, but whether increased MGAT activity plays a role in the etiology of NASH is unclear. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5425

Platform:

GPL6887

8 Samples

Download data: TXT

Analysis of liver from diet-induced obese males depleted for monoacylglycerol acyltransferase 1 (Mogat1) via intraperitoneal injections of antisense oligonucleotide directed against Mogat1. Results provide insight into the role of Mogat1 in the development of nonalcoholic steatohepatitis (NASH).

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL6887

Series:

GSE60349

8 Samples

Download data

(Submitter supplied) The nuclear receptor TAK1/TR4/NR2C2 is expressed in several tissues that are important in the control of energy homeostasis. TAK1-deficient (TAK1-/-) mice are resistant to the development of age- and high fat diet (HFD)-induced metabolic syndrome. Biochemical analysis showed significantly lower hepatic triglyceride levels and reduced lipid accumulation in adipose tissue in TAK1-/- mice compared to wild type (WT) mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

10 Samples

Download data: TIFF, TXT

(Submitter supplied) CD44 expression has been shown to be enhanced in the liver and white adipose tissue (WAT) during obesity, suggesting a possible regulatory role for CD44 in metabolic syndrome. To study this hypothesis, we compared the gene expression profiles in liver and in WAT between WT and CD44 knockout (CD44KO) mice fed a high-fat diet (HFD) for 21 weeks. This analysis demonstrated that several genes associated with triglyceride synthesis and accumulation, including Mogat2, Cidea, Cidea, Apoa4, and Elovl7, were decreased in the livers of CD44KO mice compared to WT mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

20 Samples

Download data: TXT

(Submitter supplied) We demonstrated that RORa-deficient staggerer mice (RORasg/sg) fed with a high fat diet (HFD) showed reduced adiposity and hepatic triglyceride levels compared to wild type (WT) littermates and were resistant to the development of hepatic steatosis, adipose-associated inflammation, and insulin resistance. Gene expression profiling showed that many genes involved in triglyceride synthesis and storage, including Cidec, Cidea, and Mogat1, were expressed at much lower levels in liver of RORasg/sg mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

20 Samples

Download data: TIFF, TXT

(Submitter supplied) Excessive supernutrition can lead to metabolic syndrome, liver steatosis and NAFLD. To find genes involved in metabolic regulation might be helpfull in treating metabolic diseases. We used microarray analysis to identify possible new targets of microRNA-100 in liver tissue.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

8 Samples

Download data: CEL