GEO DataSets

(Submitter supplied) Lentiviral vector (LV)-mediated gene transfer is a promising method of gene therapy. We previously reported that systemic injection of LV triggers a transient inflammatory response. Here, we carried out studies to better characterize this response, and to develop a strategy to overcome the effects of interferon (IFN) on LV-mediated gene transfer. We profiled gene expression in the liver after LV administration using deep-sequencing, and identified several innate response pathways. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

6 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of macrophages (of various genetic backgrounds) infected with L. monocytogenes or transfected with purified ligands Keywords: Timecourse, cell type comparison, bacteria strain comparison, drug comparison, ligand comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL5137

81 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of WT macrophages transfected with L. monocytogenes genomic DNA, synthetic MDP, or both Keywords: Ligand comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL5137

8 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of WT macrophages infected with WT L. monocytogenes for 180 minutes, with or without CAPE treatment Keywords: Drug comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL5137

8 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of WT and irf3-/- macrophages infected with WT L. monocytogenes for 180 minutes Keywords: Cell type comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL5137

12 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of WT and myd88-/- macrophages infected with WT and hly- L. monocytogenes for 30, 60, 120, or 180 minutes Keywords: Timecourse, cell type comparison, bacteria strain comparison.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL5137

53 Samples

Download data: GPR

(Submitter supplied) Intestinal epithelial cells of 28-day-old female mice were isolated according to a recently published protocol (Lotz et al., J Exp. Med. 2006).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

20 Samples

Download data: TXT