GEO DataSets

(Submitter supplied) We have shown that C57BL/6J CCR5 knockout mice develop 30.4% ± 8.6% fewer B16 F10 lung nodules compared to wild type mice after the intravenous injection of 100,000 B16 F10 cells. We sought to understand this phenomenon by comparing gene expression in the lungs of these mice at 6, 24, and 48 hours after tumor injection.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4840

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of lungs from CCR5-deficient mutants 6 to 48 hrs after tail vein injection with B16-F10 melanoma cells. Lungs of CCR5-deficient mutants develop fewer metastatic nodules than in wild type animals. Results provide insight into the molecular mechanisms underlying CCR5-dependent metastasis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 3 time sets

Platform:

GPL1261

Series:

GSE51422

6 Samples

Download data: CEL

(Submitter supplied) Little is known about genes that promote melanoma cell growth and proliferation. siRNAs may be used to address the role of individual genesin these processes. RNAi library screens were used in the past to gain a comprehensive overview of all genes involved in cell growth, proliferation, migration and other cellular processes. A large-scale loss-of-function screen for eight different melanoma cell lines was performed using a pooled lentiviral shRNA library (GeneNet Human 50K lentiviral shRNA Library,cat#SI206B-1, System Biosciences) to identify genes relevant for melanoma cell growth and proliferation. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL17118

16 Samples

Download data: CEL, TXT

(Submitter supplied) Analysis of MDSC subsets from naive blood and RMA-S blood and RMA-S tumor, respectively. Tumor-infiltrating MO-MDSCs changed their expression pattern compared to blood and exhibited high levels of chemokines

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6105

18 Samples

Download data: CSV, TXT

(Submitter supplied) Mouse embryonic fibroblasts (MEFs) were generated from 13.5-day-old embryos obtained from heterozygous PKBa mice intercrosses (Yang et al., 2003). Briefly, after dissection of head and visceral organs for genotyping, embryos were minced and trypsinized for 30 min at 37°C. Embryonic fibroblasts were then plated and maintained in Dulbecco’s Modified Eagle Medium (DMEM) with 10% foetal calf serum (FCS) (Life Technologies), 100 units/ml of penicillin and 100 mg/ml of streptomycin at 37°C in an atmosphere of 5% CO2. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1784

Platform:

GPL339

36 Samples

Download data

Analysis of protein kinase B alpha (PKBalpha) knockout embryonic fibroblasts (MEFs) following treatment with a standard induction cocktail to induce differentiation into adipocytes. Cells examined up to 48 hours following treatment. Results provide insight into the role of PKBalpha in adipogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 5 time sets

Platform:

GPL339

Series:

GSE2746

36 Samples

Download data

(Submitter supplied) tumor microenviroment facilitates metastatic spread by eliciting reversible changes in the phenotypes of cancer cells Keywords: expression analysis of breast tumor samples

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

22 Samples

Download data: CEL, DCP

(Submitter supplied) We hypothesized that miRNAs in the bone maroow mesenchymal stem cells (BM-MSC)-derived exosomes contributed to the phenotype change of breast cancer cells through exosome transfer. We analyzed the miRNA expression signature in BM-MSC-derived exosomes. We compared the miRNA expression levels in exosomes between BM-MSCs and adult fibroblasts (as a control).

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15446

8 Samples

Download data: TXT

(Submitter supplied) To clarify and compare gene expression profile of each cell line, we have employed microarray expression profiling. The expression of many genes was similar in MM231-D3H2LN-GFP-BM2 cells parental cells, MM231-D3H2LN-GFP cells; however, the expression of genes related to the cell cycle was decreased in the BM2 cells compared with the parental cells. We also confirmed that the global gene expression patterns of the CD44+ and CD44- MM231-D3H2LN-GFP-BM2 cells were similar, although some genes which encode proteins that breast cancer cell dormancy, such as SRC and ERBB2 were increased and decreased, respectively, in the CD44- population.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16699

4 Samples

Download data: TXT