GEO DataSets

(Submitter supplied) Smoking-induced lung disease is one of the most prevalent forms of lung disease but also one of the more diverse. Based on the phenotypic diversity caused by the same environmental stress, we hypothesized that smoking may induce changes in lung cell expression of genes that, with specific variants, are causative of monogenic lung disease, i.e., not that smoking induces a phenocopy of a genetic disease, but smoking may subtly modify the expression of genes known to be associated with genetic disorders with distinct lung disease phenotypes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

230 Samples

Download data: CEL, CHP

(Submitter supplied) RNA was obtained from histologically normal bronchial epithelium of smokers during time of clinical bronchoscopy from relatively accessible airway tissue. Gene expression data from smokers with lung cancer was compared with samples from smokers without lung cancer. This allowed us to generate a diagnostic gene expression profile that could distinguish the two classes. This profile could provide additional clinical benefit in diagnosing cancer amongst smokers with suspect lung cancer. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2771

Platform:

GPL96

192 Samples

Download data

Analysis of large airway epithelial cells from cigarette smokers without cancer, with cancer, and with suspect lung cancer. Results provide insight into the feasibility of using gene expression to detect early stage lung cancer in smokers.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state sets

Platform:

GPL96

Series:

GSE4115

192 Samples

Download data

(Submitter supplied) Although a number of animal model studies have addressed changes in gene expression in the parenchyma and their relationship to emphysema, much less is known about the pathogenesis of cigarette smoke-induced small airway remodeling. In this study, we exposed rat tracheal explants to whole smoke for 15 minutes, and then cultured the explants in air. The airway transcriptome was evaluated using RAE 230_2 GeneChips. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3746

Platform:

GPL1355

47 Samples

Download data: CEL

Analysis of tracheal explants at 2hrs and 24hrs following brief exposure to whole smoke. Some of the explants were pretreated with dexamethasone prior to smoke exposure. Results provide insight into the molecular mechanisms underlying pathogenesis of cigarette smoke-induced small airway remodeling.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 stress, 2 time sets

Platform:

GPL1355

Series:

GSE15563

47 Samples

Download data: CEL