Similar studies for GEO DataSets (Select 200063944) - GEO DataSets

Select item 2000639441.

small RNA-Seq of the CA1 hippocampal subregion from 3 month and 20 month old animals treated orally with vehicle or SAHA

(Submitter supplied) Aging and increased amyloid burden are major risk factors for cognitive diseases such as Alzheimer's Disease (AD). An effective therapy does not yet exist. Here we use mouse models for age-associated memory impairment and amyloid deposition to study transcriptome and cell type-specific epigenome plasticity at the systems level in the brain and in peripheral organs. We show that at the level of epigenetic gene-expression aging and amyloid pathology are associated with inflammation and impaired synaptic function in the hippocampal CA1 region. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL13112
19 Samples

Download data: TXT

Series

Accession:: GSE63944

ID:: 200063944

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000639452.

Reinstating transcriptome plasticity and memory function in mouse models for cognitive decline

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL13112
112 Samples

Download data: TXT

Series

Accession:: GSE63945

ID:: 200063945

PubMed Full text in PMC Similar studies

Select item 2000639433.

mRNA-Seq of the CA1 hippocampal subregion and liver from 3 month and 20 month old animals treated orally with vehicle or SAHA and mRNA-Seq of CA1 of 10 month old WT or APP/PS1-21 transgenic animals treated orally with vehicle or SAHA

(Submitter supplied) Aging and increased amyloid burden are major risk factors for cognitive diseases such as Alzheimer's Disease (AD). An effective therapy does not yet exist. Here we use mouse models for age-associated memory impairment and amyloid deposition to study transcriptome and cell type-specific epigenome plasticity at the systems level in the brain and in peripheral organs. We show that at the level of epigenetic gene-expression aging and amyloid pathology are associated with inflammation and impaired synaptic function in the hippocampal CA1 region. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
69 Samples

Download data: TXT

Series

Accession:: GSE63943

ID:: 200063943

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000639424.

Genome-wide analysis of H4K12 acetylation in neuronal and non-neuronal nuclei in young animals treated with vehicle, WT littermates of APP/PS1-21 animals treated with vehicle and aged and APP/PS1-21 animals treated with oral vehicle or SAHA for 4 weeks

(Submitter supplied) Aging and increased amyloid burden are major risk factors for cognitive diseases such as Alzheimer's Disease (AD). An effective therapy does not yet exist. Here we use mouse models for age-associated memory impairment and amyloid deposition to study transcriptome and cell type-specific epigenome plasticity at the systems level in the brain and in peripheral organs. We show that at the level of epigenetic gene-expression aging and amyloid pathology are associated with inflammation and impaired synaptic function in the hippocampal CA1 region. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
24 Samples

Download data: TXT

Series

Accession:: GSE63942

ID:: 200063942

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000202705.

Altered gene expression is associated with age-dependent memory impairment

(Submitter supplied) The mechanisms underlying age-associated memory impairment are not well understood. We have shown that the onset of memory disturbances in the aging brain is associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation. To analyze if deregulated H4K12 acetylation impacts on learning-induced gene-expression required for memory consolidation we performed a high-density oligonucleotide microarray to compare the entire hippocampal gene-expression profile of 3 and 16-month-old mice during memory consolidation.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
24 Samples

Download data: TXT

Series

Accession:: GSE20270

ID:: 200020270

Select item 2000635906.

Pharmacological HDAC inhibition attenuates cardiac hypertrophy and histone acetylation of target genes

(Submitter supplied) Cardiac hypertrophy is characterized by an increase in heart size and profound gene expression changes. Pharmacological histone deacetylase (HDAC) inhibitors attenuate pathological cardiac remodeling and hypertrophic gene expression. Published literature has linked enzymes that mediates histone acetylation to pathogenesis, however, the role of histone acetylation to define hypertrophic gene regulatory events are not well understood. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11002
4 Samples

Download data: BED, TXT

Series

Accession:: GSE63590

ID:: 200063590

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Select item 2000448687.

Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL6246 GPL13112 GPL9250
43 Samples

Download data: CEL, WIG

Series

Accession:: GSE44868

ID:: 200044868

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000434398.

Genomic topography of HDACi-induced hyperacetylation of hippocampal chromatin [ChIP-Seq]

(Submitter supplied) Histone deacetylase inhibitors (HDACis) have been shown to potentiate hippocampal-dependent memory and synaptic plasticity and to ameliorate cognitive deficits and degeneration in animal models for different neuropsychiatric conditions. However, the impact of these drugs on hippocampal histone acetylation and gene expression profiles at the genomic level, and the molecular mechanisms that underlie their specificity and beneficial effects in neural tissue, remains obscure. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13112 GPL9250
15 Samples

Download data: WIG

Series

Accession:: GSE43439

ID:: 200043439

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000430519.

Gene expression profiling of neural HDAC inhibition

(Submitter supplied) Histone deacetylase inhibitors (HDACis) have been shown to potentiate hippocampal-dependent memory and synaptic plasticity and to ameliorate cognitive deficits and degeneration in animal models for different neuropsychiatric conditions. However, the impact of these drugs on hippocampal histone acetylation and gene expression profiles at the genomic level, and the molecular mechanisms that underlie their specificity and beneficial effects in neural tissue, remains obscure. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
28 Samples

Download data: CEL

Series

Accession:: GSE43051

ID:: 200043051

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006224010.

A novel approach to Alzheimer’s Disease treatment: HDACs & PDE5 inhibition

(Submitter supplied) Considering the numerous complex and different pathological mechanisms involved in Alzheimer´s disease (AD) progression, treatments targeting a single cause may lead to limited benefits. The goal of this study was the identification of a novel mode of action for this unmet need. Pharmacological tool compounds: suberoylanilide hydroxamic acid (SAHA) and tadalafil, targeting histone deacetylases (HDAC) and phosphodiesterase 5 (PDE5) respectively, were utilized simultaneously for in-vitro and in-vivo Proof-of-Concept (PoC). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
24 Samples

Download data: CEL

Series

Accession:: GSE62240

ID:: 200062240

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010336011.

Epigenetic correction of defective plasticity in a tauopathy mouse model with an acetyltransferase activator

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
29 Samples

Download data: WIG

Series

Accession:: GSE103360

ID:: 200103360

PubMed Full text in PMC Similar studies

Select item 20010335912.

Epigenetic correction of defective plasticity in a tauopathy mouse model with an acetyltransferase activator [RNA-Seq]

(Submitter supplied) In the adult brain, histone acetylation is associated with activity-regulated transcriptional changes that are required for synaptic plasticity and memory. These processes are dismantled in neurodegenerative diseases. Here, we demonstrate that synaptic plasticity and memory deficiencies can be restored in a mouse model of tauopathy following treatment with CSP-TTK21, a small molecule activator of CBP/p300 histone acetyltransferases (HAT). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
14 Samples

Download data: TXT

Series

Accession:: GSE103359

ID:: 200103359

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010335813.

Epigenetic correction of defective plasticity in a tauopathy mouse model with an acetyltransferase activator [ChIP-Seq]

(Submitter supplied) In the adult brain, histone acetylation is associated with activity-regulated transcriptional changes that are required for synaptic plasticity and memory. These processes are dismantled in neurodegenerative diseases. Here, we demonstrate that synaptic plasticity and memory deficiencies can be restored in a mouse model of tauopathy following treatment with CSP-TTK21, a small molecule activator of CBP/p300 histone acetyltransferases (HAT). more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
15 Samples

Download data: WIG

Series

Accession:: GSE103358

ID:: 200103358

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017210914.

Experience modulates the effects of histone deacetylase inhibitors on gene and protein expression in the hippocampus: Impaired plasticity in aging

(Submitter supplied) The therapeutic potential of histone deacetylase inhibitor (HDACi) treatment has attracted considerable attention in the emerging area of cognitive neuroepigenetics. The possibility that ongoing cognitive experience importantly regulates the cell biological effects of HDACi administration, however, has not been systematically examined. In an initial experiment addressing this issue, we tested whether water maze training influences the gene expression response to acute systemic HDACi administration in the young adult rat hippocampus. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL6101
84 Samples

Download data: TXT

Series

Accession:: GSE172109

ID:: 200172109

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008744115.

The transcription factor Sp3 cooperates with HDAC2 to regulate synaptic function and plasticity in neurons

(Submitter supplied) The histone deacetylase HDAC2, which negatively regulates neuronal plasticity and synaptic gene expression, is upregulated both in Alzheimer’s disease (AD) patients and mouse models (Graff et al., 2012). Therapeutics targeting HDAC2 are speculated to be a promising avenue for ameliorating AD related cognitive impairment. However, attempts to generate HDAC2-specific inhibitors have not been successful. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: TXT

Series

Accession:: GSE87441

ID:: 200087441

PubMed Similar studies SRA Run Selector

Select item 20015969916.

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease (RNA-seq) [RNA-seq]

(Submitter supplied) We report the bulk RNA-seq in human hippocampus subject to normal aging and Alzheimer's disease.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
30 Samples

Download data: TXT

Series

Accession:: GSE159699

ID:: 200159699

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20015967117.

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease (5hmC) [5hmC-Seal]

(Submitter supplied) We report the 5hmC in human hippocampus subject to normal aging and Alzheimer's disease.

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL18573
28 Samples

Download data: BED

Series

Accession:: GSE159671

ID:: 200159671

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015387518.

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL18573
234 Samples

Download data: BED, BW

Series

Accession:: GSE153875

ID:: 200153875

PubMed Full text in PMC Similar studies

Select item 20015387319.

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease (RNA-seq with ERCC spike-in) [RNA-Seq]

(Submitter supplied) We report the ERCC spike-in controlled RNA-seq in human hippocampus subject to normal aging and Alzheimer's disease.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
30 Samples

Download data: TXT, XLSX

Series

Accession:: GSE153873

ID:: 200153873

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20013074620.

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease (H3K9ac, H3K27ac, H3K122ac, H3K4me1) [ChIP-Seq]

(Submitter supplied) We report the epigenetic landscape of multiple histone marks in human hippocampus subject to normal aging and Alzheimer's disease.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
146 Samples

Download data: BED, BW, XLSX

Series

Accession:: GSE130746

ID:: 200130746

PubMed Full text in PMC Similar studies SRA Run Selector

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