Similar studies for GEO DataSets (Select 200066565) - GEO DataSets

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Items: 20

Select item 2000665651.

Microarray analysis of committed cDC progenitors

(Submitter supplied) Analysis of stage-specific gene expression in Zbtb46GFP/+ pre-CD8 DCs, pre-CD4 DCs, CD24 cDCs and CD172a cDCs

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
12 Samples

Download data: CEL

Series

Accession:: GSE66565

ID:: 200066565

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000668992.

Batf3 maintains Irf8 autoactivation for commitment of a novel clonogenic progenitor of CD8+DCs

(Submitter supplied) The transcription factors Batf3 and IRF8 are required for development of CD8α+ conventional dendritic cells (cDCs), but the basis for their actions was unclear. Here, we identify two novel Zbtb46+ progenitors that separately generate CD8α+ and CD4+ cDCs and arise directly from the common DC progenitor (CDP). Irf8 expression in the CDP depends on prior PU.1-dependent autoactivation, and specification of pre-CD8 DC progenitors requires IRF8 but not Batf3. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
14 Samples

Download data: BEDGRAPH

Series

Accession:: GSE66899

ID:: 200066899

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000533113.

L-Myc expression by dendritic cells is required for optimal T-cell priming

(Submitter supplied) The transcription factor IRF8 is a critical regulator of plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development in both mouse and man. Yet the downstream molecular targets that regulate DC homeostasis and development are largely unknown. A recent study using gene expression analysis of IRF8-deficient myeloid and lymphoid progenitors identified the Myc paralog Mycl1 as a potential transcriptional target of IRF8. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
3 Samples

Download data: BEDGRAPH

Series

Accession:: GSE53311

ID:: 200053311

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000173224.

Mouse lung CD103+ and CD11b-high dendritic cell (DC) subsets

(Submitter supplied) Mouse lung CD11c+ dendritic cells are composed of 2 major DC subsets, the CD103+CD11b-low/intermediate DC (CD103+ DC) and the CD11b-highCD103- DC (CD11b-high DC). These 2 subsets are functionally distinct. Comparison of their functions showed CD103+ DC Microarray analysis was performed to compare the gene expression profiles of the 2 lung DC subsets in naïve mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE17322

ID:: 200017322

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000232125.

Gene expression profiling of mouse splenic Dendritic cells subsets

(Submitter supplied) We describe a novel subset of CD8+ DCs in lymphoid organs of naïve mice characterized by expression of the CX3CR1 chemokine receptor. CX3CR1+CD8+ DCs lack hallmarks of classical CD8+ DCs, including IL12 secretion, the capacity to cross-present antigen and their developmental independence of the transcriptional factor BatF3. Gene expression profiling showed that CX3CR1+CD8+ DCs resemble CD8- cDCs. The microarray analysis further revealed a unique plasmacytoid DC (PDC) gene signature of CX3CR1+ CD8+ DCs. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE23212

ID:: 200023212

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000406476.

Microarray analysis of WT and Batf3-/- CD8alpha dendritic cells from C57BL/6 spleen

(Submitter supplied) Batf3 regulates key CD8alpha DC-specific genes.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE40647

ID:: 200040647

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000607837.

Identification of subset-specific dendritic cell progenitors reveals early commitment in the bone marrow

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL6887 GPL13112
275 Samples

Download data: TXT

Series

Accession:: GSE60783

ID:: 200060783

Select item 2000607828.

Identification of subset-specific dendritic cell progenitors reveals early commitment in the bone marrow [Microarray Expression]

(Submitter supplied) Dendritic cells (DCs) are antigen sensing and presenting cells that are essential for effective immunity. Existing as a multi-subset population, divided by distinct developmental and functional characteristics1,2, DC subsets play important and unique roles in responses to pathogens, vaccines and cancer therapies, as well as during immune-pathologies. Therefore therapeutic manipulation of the DC compartment is an attractive strategy. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
24 Samples

Download data: TXT

Series

Accession:: GSE60782

ID:: 200060782

Select item 2000607819.

Identification of subset-specific dendritic cell progenitors reveals early commitment in the bone marrow [RNA-Seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
251 Samples

Download data: TXT

Series

Accession:: GSE60781

ID:: 200060781

PubMed Similar studies SRA Run Selector

Select item 20014045210.

Gene expression data from mouse conventional dendritic cells (cDC) [Batf, Batf3 DKO]

(Submitter supplied) We used microarrays to understand roles of BATF proteins in the regulation of cDC-specific gene expression.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
9 Samples

Download data: CEL

Series

Accession:: GSE140452

ID:: 200140452

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014045111.

Gene expression data from mouse conventional dendritic cells (cDC) [IRF4,IRF8 DKO]

(Submitter supplied) We used microarrays to detail cDC gene expression program controlled by IRF4 and IRF8.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
12 Samples

Download data: CEL

Series

Accession:: GSE140451

ID:: 200140451

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013277012.

An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development (RNA-Seq)

(Submitter supplied) Classical type 1 dendritic cells (cDC1s) are required for anti-viral and anti-tumor immunity, which has motivated a need to understand their development. The development of the cDC1 progentitor requires an E protein–dependent enhancer located 41 kilobases downstream of the transcription start site of the transcription factor IRF8 (+41 kb Irf8 enhancer) but its maturation instead requires the BATF3-dependent +32 kb Irf8 enhancer. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
1 Sample

Download data: MTX, TSV

Series

Accession:: GSE132770

ID:: 200132770

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012380013.

An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
54 Samples

Download data: CEL

Series

Accession:: GSE123800

ID:: 200123800

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012379914.

Expression data from WT, Batf3, and Id2 KO CDPs or Zbtb46-GFP+ cKit intermediate cells in the bone marrow.

(Submitter supplied) We used microarrays to detail the programme of gene expression underlying CDP commitment to cDC1 lineage and identify differentially regulated genes during this process.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
15 Samples

Download data: CEL

Series

Accession:: GSE123799

ID:: 200123799

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012379815.

Expression data from WT and Id2 KO splenic cDC2

(Submitter supplied) We used microarrays to detail the genes regulating cDC2 development in the absense of the transcription factor Id2.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
4 Samples

Download data: CEL

Series

Accession:: GSE123798

ID:: 200123798

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012379716.

Expression data from WT cDC1s, Zeb2 KO cDC1s, Nfil3 Zeb2 DKO cDC1s and Zeb2 Id2 DKO cDC1s

(Submitter supplied) We used microarrays to determine whether cDC1s from the two double KO are bona fide cDC1s, and what are the transcriptional changes within these cDC1s.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
10 Samples

Download data: CEL

Series

Accession:: GSE123797

ID:: 200123797

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012379617.

Expression data from Id2-GFP- CDPs, Id2-GFP+ CDPs, Id2-GFP- pre-CD8, and Id2-GFP+ pre-CD8.

(Submitter supplied) We used microarrays to detail the programme of gene expression underlying CDP commitment to cDC1 lineage and identify differentially regulated genes during this process.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
8 Samples

Download data: CEL

Series

Accession:: GSE123796

ID:: 200123796

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012379418.

Expression data from Zeb2hi CDPs, Zeb2low CDPs, and pre-CD8 DCs

(Submitter supplied) We used microarrays to detail the programme of gene expression underlying CDP commitment to cDC1 lineage and identify differentially regulated genes during this process.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
8 Samples

Download data: CEL

Series

Accession:: GSE123794

ID:: 200123794

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012374719.

Expression data from Zbtb46- CDPs, Zbtb46+ CDPs, and pre-CD8 DCs

(Submitter supplied) We used microarrays to detail the programme of gene expression underlying CDP commitment to cDC1 lineage and identify differentially regulated genes during this process.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
9 Samples

Download data: CEL

Series

Accession:: GSE123747

ID:: 200123747

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005447220.

Induced CD103+ Dendritic Cells

(Submitter supplied) Multiple subsets of FLT3L-dependent dendritic cells (DCs) control T cell tolerance and immunity. In mouse tissues, CD8α-like DCs are identified by CD103 expression. This DC subset efficiently enters lymph nodes and cross-presents antigens, rendering CD103+ DCs promising targets for therapeutic tolerance induction or vaccination. However, only limited numbers of CD103+ DCs can be isolated with current methods. more...