Similar studies for GEO DataSets (Select 200075422) - GEO DataSets

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Items: 15

Select item 2000754221.

miRNA expression profiles in decidualized and non-decidualized endometriotic cyst stromal cells (ECSCs).

(Submitter supplied) To identify the miRNAs which regulate the decidualization of ECSCs, we explored differentially expressed miRNAs between untreated ECSCs (n=4) and decidualized ECSCs (n=4) using miRNA microarray. The miRNA expression profiles in untreated ECSCs and decidualized ECSCs were obtained, then the miRNAs were filtered by signal intensity (50.0<, at least one out of 8 samples have values within range) and flags (at least 17% of cases have good flags). more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL18402
8 Samples

Download data: TXT

Series

Accession:: GSE75422

ID:: 200075422

Select item 2000754272.

Expression profiles in decidualized and non-decidualized endometriotic cyst stromal cells (ECSCs) and normal endometrial stromal cells (NESCs)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL18402 GPL17077 GPL13497
32 Samples

Download data: TXT

Series

Accession:: GSE75427

ID:: 200075427

Select item 2000754253.

mRNA expression profiles in decidualized and non-decidualized normal endometrial stromal cells (NESCs).

(Submitter supplied) To identify the mRNAs which regulate endomrtial decidualization, we explored differentially expressed mRNAs between untreated NESCs (n=4) and decidualized NESCs (n=4) using gene expression microarray. The mRNA expression profiles of untreated in NESCs and decidualized NESCs were obtained, then the mRNAs were filtered by signal intensity (50.0<, at least one out of 8 samples have values within range) and flags (at least 43% of cases have good flags). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
8 Samples

Download data: TXT

Series

Accession:: GSE75425

ID:: 200075425

Select item 2000754244.

miRNA expression profiles in decidualized and non-decidualized normal endometrial stromal cells (NESCs).

(Submitter supplied) To identify the miRNAs which regulate endometrial decidualization, we explored differentially expressed miRNAs between untreated NESCs (n=4) and decidualized NESCs (n=4) using miRNA microarray. The miRNA expression profiles of untreated NESCs and decidualized NESCs were obtained, then the miRNAs were filtered by signal intensity (50.0<, at least one out of 8 samples have values within range) and flags (at least 13% of cases have good flags). more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL18402
8 Samples

Download data: TXT

Series

Accession:: GSE75424

ID:: 200075424

Select item 2000754235.

mRNA expression profiles in decidualized and non-decidualized endometriotic cyst stromal cells (ECSCs).

(Submitter supplied) To identify the mRNAs which regulate the decidualization of ECSCs, we explored differentially expressed mRNAs between untreated ECSCs (n=4) and decidualized ECSCs (n=4) using gene expression microarray. The mRNA expression profiles in untreated ECSCs and decidualized ECSCs were obtained, then the mRNAs were filtered by signal intensity (50.0<, at least one out of 8 samples have values within range) and flags (at least 58% of cases have good flags). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13497
8 Samples

Download data: TXT

Series

Accession:: GSE75423

ID:: 200075423

Select item 2000401866.

miRNA expression profiles in endometriotic cyst stromal cells (ECSCs).

(Submitter supplied) To identify the miRNAs which play a role in the development of endometriosis, we explored differentially expressed miRNAs between ECSCs (N=8) and normal endometrial stromal cells (NESCs, n=8) using miRNA microarray. The expression profiles in ECSCs and NESCs were obtained, then the miRNAs were filtered by signal intensity (20.0<, at least one out of 16 samples have values within range) and flags (at least 70% of cases have good flags). more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL14767
16 Samples

Download data: TXT, XLSX

Series

Accession:: GSE40186

ID:: 200040186

Select item 2000568547.

Compulsory expression of miR-210 in normal endometrial stromal cells

(Submitter supplied) Compulsory expression of miR-210 in normal endometrial stromal cells directed the induction of cell proliferation and vascular endothelial growth factor production, and the inhibition of apoptosis in through signal transducer and activator of transcription 3 (STAT3) activation. Accumulating evidence suggests that microRNAs play definite roles in the pathogenesis of endometriosis. The objective of the study was to determine the role of miR-210, one of the upregulated microRNA in endometriotic cyst stromal cells, in the pathogenesis of endometriosis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13497
8 Samples

Download data: TXT

Series

Accession:: GSE56854

ID:: 200056854

Select item 2001399548.

Gene expression profiles of miR-100-5p-transfected normal endometrial stromal cells

(Submitter supplied) Accumulating evidence suggests that microRNAs play definite roles in the pathogenesis of endometriosis. The objective of the study was to determine the role of miR-100-5p, one of the upregulated microRNA in endometriotic cyst stromal cells, in the pathogenesis of endometriosis. Downstream targets of miR-100-5p were identified by compulsory expression of miR-100-5p in normal eutopic endometrial stromal cells (NESCs), a global mRNA microarray technique, and pathways analysis.Compulsory expression of miR-100-5p in NESCs directed the induction of cell motility through SWItch/sucrose non-fermentable (SWI/SNF)-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) supression and matrix metallopeptidase 1 (MMP1) activation.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
8 Samples

Download data: TXT

Series

Accession:: GSE139954

ID:: 200139954

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001214069.

miRNA expression profiles of uncultured stromal cells of eutopic and ectopic origin

(Submitter supplied) We utilized fluorescence-activated cell sorting to isolate endometrial stromal cells from paired endometrial and endometrioma biopsies and combined it with high-throughput sequencing to determine miRNA alterations in endometriotic stroma. The analysis revealed 149 abnormally expressed miRNAs in endometriotic lesions, including extensive upregulation of miR-139-5p and downregulation of miR-375 compared to eutopic cells. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: TAB

Series

Accession:: GSE121406

ID:: 200121406

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006182710.

Expression data from in vitro decidualized human uterine fibroblast cells (HuF cells) with or without NOTCH1 silencing

(Submitter supplied) Decidualization is a critical process for embryo implatation during which uterine stromal fibroblasts are transformed into large, epithelioid-like decidual cell. NOTCH1 is recepotor of Notch signaling that plays important roles for cell-cell communication, which involves gene regulatory mechanisms that control multiple cellular differentiation processes during embryonic and adult life. Here we silenced NOTCH1 by shRNA in HuF cells and studied how it affects decidualization

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE61827

ID:: 200061827

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004420711.

CCAAT/enhancer-binding protein alpha is epigenetically silenced by histone acetylation in endometriosis and promotes the pathogenesis of endometriosis: a novel therapeutic target

(Submitter supplied) Accumulating evidences suggest that various epigenetic aberrations play definite roles in the pathogenesis of endometriosis. The aim of this study is to identify 1) the panel of aberrantly expressed genes that are epigenetically suppressed by histone acetylation in endometriosis; 2) the roles of CCAAT/enhancer-binding protein (C/EBP) alpha, one of the candidate molecules whose expression was epigenetically repressed in endometriotic cyst stromal cells (ECSCs), in the pathogenesis of endometriosis; and 3) the efficacy of the histone deacetylase inhibitors for the treatment of endometriosis.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13497
16 Samples

Download data: TXT

Series

Accession:: GSE44207

ID:: 200044207

Select item 20012401012.

miR-205-5p Inhibits Human Endometriosis Progression by Targeting ANGTP2 in Endometrial Stromal Cells

(Submitter supplied) the newly identified miR-205-5p-ANGPT2-AKT/ERK axis illustrates the molecular mechanism of endometriosis progression and may represent a novel diagnostic biomarker and therapeutic target for disease treatment.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL25134
6 Samples

Download data: TXT

Series

Accession:: GSE124010

ID:: 200124010

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002634613.

Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis

(Submitter supplied) Endometriosis is defined as the presence of endometrial tissue (eutopic tissue) outside the uterus (ectopic tissue). We assessed differentially expressed microRNAs in ectopic endometrium compared with eutopic endometrium.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL7372
3 Samples

Download data: TXT

Series

Accession:: GSE26346

ID:: 200026346

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002333914.

Gene expression profiles of endometriosis

(Submitter supplied) Endometriosis is a common disease seen by gynecologists. Clinical features involve pelvic pain and unexplained infertility. Although endometriosis is pathologically characterized by endometrial tissue outside the normal uterine location, endometriosis is otherwise not easily explained. Endometriomas, endometriotic cysts of the ovary, typically cause pain and distortion of pelvic anatomy. To begin to understand the pathogenesis of endometriomas, we carried out transcriptome:microRNAome analysis of endometriomas and eutopic endometrium, using gene expression arrays and next generation small RNA sequencing technology. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3975
Platform:: GPL6102
19 Samples

Download data: TXT

Series

Accession:: GSE23339

ID:: 200023339

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 397515.

Endometriosis: endometrial tissue

Analysis of endometrioma and eutopic endometrium controls. Endometriosis is a pathological condition characterized by endometrial tissue outside the normal uterine location. Results provide insight into molecular mechanisms underlying the pathology of endometriosis.