Similar studies for GEO DataSets (Select 200085206) - GEO DataSets

Select item 2000852061.

Expression of oxysterol pathway genes in estrogen positive breast carcinomas-second phase

(Submitter supplied) Metabolism of anticancer drugs markedly affects their antitumor effects. The major goal of our study was to investigate associations of gene expression of enzymes metabolizing taxanes and/or anthracyclines with therapy response and survival of breast carcinoma patients The present study investigated transcript levels of key modulators of oxysterol signaling pathway, including oxysterol receptors, metabolic enzymes and transporters in the group of hormone-receptor positive breast carcinoma patients to evaluated potential clinical significance of these genes.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL19921
164 Samples

Download data: TXT

Series

Accession:: GSE85206

ID:: 200085206

Select item 2000852082.

Expression of oxysterol pathway genes in estrogen positive breast carcinomas

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL19921
203 Samples

Download data

Series

Accession:: GSE85208

ID:: 200085208

Select item 2000852073.

Expression of oxysterol pathway genes in estrogen positive breast carcinomas-first phase

(Submitter supplied) Metabolism of anticancer drugs markedly affects their antitumor effects. The major goal of our study was to investigate associations of gene expression of enzymes metabolizing taxanes and/or anthracyclines with therapy response and survival of breast carcinoma patients The present study investigated differences in transcript levels of key modulators of oxysterol signaling pathway, including oxysterol receptors, metabolic enzymes and transporters in the groups of estrogen receptor positive (ER+) breast carcinomas in comparison to estrogen receptor negative (ER-) ones, and to control non-tumor tissues.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL19921
39 Samples

Download data: TXT

Series

Accession:: GSE85207

ID:: 200085207

Select item 2000759714.

Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor positive breast cancer

(Submitter supplied) Therapies targeting estrogenic stimulation in estrogen receptor positive (ER+) breast cancer (BC) reduce mortality, but resistance remains a major clinical problem. Molecular studies have shown few high frequency mutations to be associated with endocrine resistance. In contrast, expression profiling of primary ER+ BC samples has identified several promising signatures/networks for targeting. In this study, the cholesterol biosynthesis pathway was the common upregulated pathway in the ER+ LTED but not ER- LTED cell lines, suggesting a potential mechanism dependent on continued ER expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
54 Samples

Download data: TXT

Series

Accession:: GSE75971

ID:: 200075971

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000046115.

Breast Cancer Gene Expression Data from Frankfurt Series

(Submitter supplied) Pooling of microarray datasets seems to be a reasonable approach to increase sample size when a heterogeneous disease like breast cancer is concerned. Different methods for the adaption of datasets have been used in the literature. We have analyzed influences of these strategies using a pool of 3,030 Affymetrix U133A microarrays from breast cancer samples. We present data on the resulting concordance with biochemical assays of well known parameters and highlight critical pitfalls. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
218 Samples

Download data: CEL

Series

Accession:: GSE4611

ID:: 200004611

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001192626.

Gene expression profiling of pre-operative mTOR inhibitor everolimus treatment in breast cancer

(Submitter supplied) There is growing evidence that uncontrolled activation of the PI3K/Akt/mTOR pathway contributes to the development and progression of breast cancer. Inhibition of this pathway has antitumour effects in preclinical studies and efficacy in combination with other agents in breast cancer patients. The aim of this study is to characterise the effects of pre-operative everolimus treatment in primary breast cancer patients and to identify potential molecular predictors of response. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6104
88 Samples

Download data: TXT

Series

Accession:: GSE119262

ID:: 200119262

Select item 2002253287.

Transcriptome profiling in early-stage luminal breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL18402 GPL18573
192 Samples

Download data: TXT

Series

Accession:: GSE225328

ID:: 200225328

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002253278.

Integrative analysis of mRNA-miRNA expression profiles and somatic variants in oxysterol signaling in early-stage luminal breast cancer

(Submitter supplied) Oxysterols, oxidized derivatives of cholesterol, act in breast cancer (BC) as selective estrogen receptor modulators and affect cholesterol homeostasis, drug transport, nuclear and cell receptors, and other signaling proteins. Using overlapping data from patients with early-stage estrogen receptor-positive BC—high-coverage targeted DNA sequencing (99 patients, 113 genes), mRNA sequencing (67 patients), and full miRNome by microarrays (123 patients)—we describe complex mRNA-miRNA and miRNA-miRNA interaction (correlation) networks, with validation in two carefully curated public datasets (n=538 in total) and 11 databases. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
67 Samples

Download data: TSV

Series

Accession:: GSE225327

ID:: 200225327

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002252929.

miRNA transcriptome profiling in early-stage luminal breast cancer

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL18402
125 Samples

Download data: TXT

Series

Accession:: GSE225292

ID:: 200225292

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007337110.

FOXM1 Cistrome Predicts Breast Cancer Metastatic Outcome Better Than FOXM1 Expression Levels or Tumor Proliferation Index

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL9115
8 Samples

Download data: TXT

Series

Accession:: GSE73371

ID:: 200073371

PubMed Similar studies

Select item 20007337011.

FOXM1 Cistrome Predicts Breast Cancer Metastatic Outcome Better Than FOXM1 Expression Levels or Tumor Proliferation Index [RNA-Seq]

(Submitter supplied) FOXM1 is a key transcription factor regulating cell cycle progression, DNA damage response, and a host of other hallmark cancer features, but the role of the FOXM1 cistrome in driving estrogen receptor-positive (ER+) vs. ER- breast cancer clinical outcomes remains undefined.