Similar studies for GEO DataSets (Select 200107734) - GEO DataSets

Select item 2001077341.

Bladder Cancer Associated Mutations in RXRA activate Peroxisome Proliferator-Activated Receptors to Drive Urothelial Proliferation

(Submitter supplied) RXRA regulates transcription as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator-activated receptors (PPARs). Analysis from the TCGA raised the possibility that hyperactive PPAR signaling, either due to PPAR gamma gene amplification or RXRA hot-spot mutation (S427F/Y) drives 20-25% of bladder cancers. Here we characterize mutant RXRA, demonstrating it induces enhancer/promoter activity in the context of RXRA/PPAR heterodimers. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21290
16 Samples

Download data: BROADPEAK, NARROWPEAK

Series

Accession:: GSE107734

ID:: 200107734

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001077832.

Bladder cancer associated mutations in RXRA activate peroxisome proliferator-activated receptors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21290 GPL16791
34 Samples

Download data: TXT

Series

Accession:: GSE107783

ID:: 200107783

PubMed Full text in PMC Similar studies

Select item 2001077353.

Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL21290
18 Samples

Download data: TXT

Series

Accession:: GSE107735

ID:: 200107735

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000927234.

Transcriptome analysis for KDM6A mutated urothelial bladder carcinoma and EZH2 inhibitor treated KDM6A mutated urothelial bladder carcinoma

(Submitter supplied) Purpose: The goals of this study are to compare 1. The transcription profile in KDM6A wildtype and KDM6A mutated urothelial bladder carcinoma. 2. The transcriptional changes in KDM6A mutated urothelial bladder carcinoma upon EZH2 inhibitor treatment.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
50 Samples

Download data: TXT

Series

Accession:: GSE92723

ID:: 200092723

Select item 2000590125.

Analysis of conceptuses from day 14 pregnancy rambouillet cross ewes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Ovis aries

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18884 GPL15670
6 Samples

Download data

Series

Accession:: GSE59012

ID:: 200059012

PubMed Similar studies

Select item 2000590116.

PPARG regulated genes in the day 14 ovine conceptus

(Submitter supplied) PPARG ChIP seq analysis was conducted to determine genes bound by and potentially regulated by PPARG in the developing ovine conceptus. Determination of gene regulation by prostaglandins through PPARG helps to improve our understanding of early pregnancy events and provides a basis for strategies to improve fertility and reproductive efficiency in ruminants.

Organism:: Ovis aries

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL15670
2 Samples

Download data: XLSX

Series

Accession:: GSE59011

ID:: 200059011

PubMed Similar studies SRA Run Selector

Select item 2000589677.

RNA seq analysis of day of pregnancy 14 ovine conceptuses

(Submitter supplied) RNA seq analysis was conducted to determine gene expression in the day 14 ovine conceptus. This was used in conjunction with the day 14 PPARG ChIP-seq analysis to identify genes bound by PPARG which were also expressed or not expressed in the day 14 conceptus. Understanding changes in gene expression during early pregnancy is critical to improving fertility and reproductive efficiency in ruminants.

Organism:: Ovis aries

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18884
4 Samples

Download data: XLSX

Series

Accession:: GSE58967

ID:: 200058967

PubMed Similar studies SRA Run Selector

Select item 2001668038.

Cell-intrinsic tumorigenic functions of PPARg in bladder urothelial carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
24 Samples

Download data: BEDGRAPH

Series

Accession:: GSE166803

ID:: 200166803

PubMed Full text in PMC Similar studies

Select item 2001668029.

Cell-intrinsic tumorigenic functions of PPARg in bladder urothelial carcinoma [ChIP-seq]

(Submitter supplied) PPARg promotes UC progression through cell-autonomous mechanisms linked to sonic hedgehog (SHH) signaling.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
8 Samples

Download data: BEDGRAPH

Series

Accession:: GSE166802

ID:: 200166802

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016680110.

Cell-intrinsic tumorigenic functions of PPARg in bladder urothelial carcinoma [RNA-seq]

(Submitter supplied) PPARg promotes UC progression through cell-autonomous mechanisms linked to sonic hedgehog (SHH) signaling.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
16 Samples

Download data: CSV

Series

Accession:: GSE166801

ID:: 200166801

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20012377911.

RNAseq data of WT and Pparg-ablated mouse urothelium under homeostasis and during regneration

(Submitter supplied) Peroxisome Proliferator-Activated Receptor-gamma (PPARG) is a nuclear hormone receptor that was originally described as a master regulator of adipogenesis but could also promote cellular differentiation in a number of epithelium. PPARG also serves as an important regulator in anti-inflammatory activity after a variety of injuries, acting in part by antagonizing the NF-kB pathway. Moreover, the expression of PPARG is strongly down regulated in the basal subtype of bladder cancer, suggesting that its removal might be essential in tumorigenesis. more...