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Links from GEO DataSets

Items: 19

1.

Co-chaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and b1 integrin function

(Submitter supplied) Plasma cell differentiation involves coordinated changes in gene expression and functional properties of B cells. Here, we study the role of Mzb1, a Grp94 co-chaperone that is expressed in marginal zone (MZ) B cells and during the terminal differentiation of B cells to antibody-secreting cells (ASCs). By analyzing Mzb1 -/- Prdm1 +/gfp mice, we find that Mzb1 is specifically required for the differentiation and function of ASCs in a T cell-independent immune response. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
12 Samples
Download data: TXT
Series
Accession:
GSE118124
ID:
200118124
2.

The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells

(Submitter supplied) Antibody secretion by plasma cells provides acute and long-term protection against pathogens. The high secretion potential of plasma cells depends on the unfolded protein response, which is controlled by the transcription factor Xbp1. Here, we analyzed the Xbp1-dependent gene expression program of plasma cells and identified Bhlha15 (Mist1) as the most strongly activated Xbp1 target gene. As Mist1 plays an important role in other secretory cell types, we analyzed in detail the phenotype of Mist1-deficient plasma cells in Cd23-Cre Bhlha15(fl/fl) mice under steady-state condition or upon NP-KLH immunization. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
13 Samples
Download data: BED, BW, TXT
Series
Accession:
GSE190591
ID:
200190591
3.

Precocious expression of Blimp1 in the B cell lineage causes autoimmunity

(Submitter supplied) The transcription factor Blimp1 is not only an essential regulator of plasma cells, but also a risk factor for the development of autoimmune disease. Here, we demonstrate that the mouse Prdm1 (Blimp1) gene was partially activated at the chromatin and transcription level in early B cell development, although mature Prdm1 mRNA did not accumulate due to posttranscriptional regulation. By analyzing a mouse model that facilitated ectopic Blimp1 protein expression throughout B lymphopoiesis, we could demonstrate that Blimp1 impaired B cell development by interfering with the B cell gene expression program, while leading to an increased abundance of plasma cells by promoting premature plasmablast differentiation of immature and mature B cells. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL13112 GPL17021
17 Samples
Download data: BW, TXT
Series
Accession:
GSE111692
ID:
200111692
4.

A dichotomy of gene regulatory associations during the activated B-cell to plasmablast transition

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16791 GPL10558
91 Samples
Download data: BED, BW
Series
Accession:
GSE142494
ID:
200142494
5.

A dichotomy of gene regulatory associations during the activated B-cell to plasmablast transition [ChIP-seq]

(Submitter supplied) The activated B-cell (ABC) to plasmablast transition is the cusp of antibody secreting cell (ASC) differentiation but is incompletely defined. We apply expression time-courses, parsimonious gene correlation network analysis, and ChIP-seq to explore this in human cells. The transition initiates with input signal loss leading within hours from cell growth dominant programs to enhanced proliferation, accompanied from 24h by ER-stress response, secretory optimization and upregulation of ASC features. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL16791
28 Samples
Download data: BED, BW
Series
Accession:
GSE142493
ID:
200142493
6.

A dichotomy of gene regulatory associations during the activated B-cell to plasmablast transition [Microarray]

(Submitter supplied) The activated B-cell (ABC) to plasmablast transition is the cusp of antibody secreting cell (ASC) differentiation but is incompletely defined. We apply expression time-courses, parsimonious gene correlation network analysis, and ChIP-seq to explore this in human cells. The transition initiates with input signal loss leading within hours from cell growth dominant programs to enhanced proliferation, accompanied from 24h by ER-stress response, secretory optimization and upregulation of ASC features. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
63 Samples
Download data: TXT
Series
Accession:
GSE142492
ID:
200142492
7.

b1-integrin regulates marginal zone B cell differentiation

(Submitter supplied) Integrin b1-deficient mice have a defect in the differentiation of MZ B cells and plasma cells.We performed a genome-wide transcriptome analysis of ex vivo-sorted Fo B, transitional B and MZ B cells of in Integrin b1 KO and Integrin b1 WT mice. We also performed invitro culture of CD93+ (AA4.1+) transitional B cells to study the role of PI3 Kinase signalling.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
26 Samples
Download data: TXT
Series
Accession:
GSE213512
ID:
200213512
8.

BLIMP-1 is insufficient to induce antibody secretion in the absence of IRF4

(Submitter supplied) Differentiation of B cells into antibody secreting cells (ASCs), plasmablasts and plasma cells, is regulated by a network of transcription factors. Within this network factors including PAX5 and BCL6 prevent ASC differentiation and maintain the B cell phenotype whereas BLIMP-1 and high IRF4 expression promote plasmacytic differentiation. BLIMP-1 is thought to induce immunoglobulin secretion. While IRF4 is needed for the survival of ASCs, its role in the regulation of antibody secretion has been controversial. more...
Organism:
Gallus gallus
Type:
Expression profiling by array
Platform:
GPL15357
8 Samples
Download data: TXT
Series
Accession:
GSE94836
ID:
200094836
9.

Principles for the regulation of multiple developmental pathways by a versatile transcriptional factor, BLIMP1

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL15907 GPL17021
39 Samples
Download data: TDF, TXT
Series
Accession:
GSE91041
ID:
200091041
10.

Principles for the regulation of multiple developmental pathways by a versatile transcriptional factor, BLIMP1 (RNA-Seq)

(Submitter supplied) Transcription factors (TFs) regulate biological events depending on cellular contexts, precise mechanisms for which are elusive. BLIMP1 has been shown to play key roles in many developmental processes, canonically as a transcriptional repressor that targets to proximities of promoters. Here, we systematically and quantitatively characterized genomic binding patterns of BLIMP1 across four distinct, developing cell types; photoreceptor precursors, embryonic intestinal epithelium, plasmablasts, and primordial germ cells (PGCs). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15907
26 Samples
Download data: TXT
Series
Accession:
GSE91040
ID:
200091040
11.

Principles for the regulation of multiple developmental pathways by a versatile transcriptional factor, BLIMP1(ChIP-Seq)

(Submitter supplied) Transcription factors (TFs) regulate biological events depending on cellular contexts, precise mechanisms for which are elusive. BLIMP1 has been shown to play key roles in many developmental processes, canonically as a transcriptional repressor that targets to proximities of promoters. Here, we systematically and quantitatively characterized genomic binding patterns of BLIMP1 across four distinct, developing cell types; photoreceptor precursors, embryonic intestinal epithelium, plasmablasts, and primordial germ cells (PGCs). more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
13 Samples
Download data: TDF, TXT
Series
Accession:
GSE91038
ID:
200091038
12.

ATAC-seq analysis of the chromatin landscape during in vitro differentiation of murine trophoblast stem cells

(Submitter supplied) Our goal was to survey changes in chromatin accessibility during early trophoblast differentiation and assess its releationship with transcriptional changes.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21103
4 Samples
Download data: BED, WIG
Series
Accession:
GSE94694
ID:
200094694
13.

ChIP-seq analysis of Blimp1 in day 2 differentiated mouse trophoblast stem cells.

(Submitter supplied) Our goal was to survey genomic binding of Blimp1 in differentiating trophoblast giant cells in order to identify direct transcriptional target genes.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: BEDGRAPH, TXT, WIG
Series
Accession:
GSE74408
ID:
200074408
14.

Gene expression in primary human B cells sorted according to IL-10 secretion or not after 2 days of activation.

(Submitter supplied) To determine characterize human B cells that express IL-10 on a molecular level, we compared the global gene expression of primary CD19pos B cells secreting IL-10 or not, upon activation with anti-CD40, IL-4 and CpG for 2 days.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE49853
ID:
200049853
15.

In vitro generation of mature murine plasma cells uncovers adaptive Prdm1 expression

(Submitter supplied) Upon encounter with antigen, B cells undergo a sequential process of differentiation to become antibody-secreting plasma cells. While the key drivers of differentiation have been identified, research has been limited by the lack of in vitro models recapitulating the full process for murine B cells. Here we describe methodology using BCR or TLR ligation to obtain plasma cells that are phenotypically mature, have exited cell cycle and express a gene signature concordant with long-lived plasma cells. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
45 Samples
Download data: TXT
Series
Accession:
GSE160823
ID:
200160823
16.

Identifying FancC-dependent transcriptional signatures in mature B cells

(Submitter supplied) We report the first RNA-Seq experiments profiling of FancC deficiency in B cells.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: TXT
Series
Accession:
GSE76634
ID:
200076634
17.

scRNA-seq of T cell Independent B cell responses

(Submitter supplied) To fine map the continuum of molecular changes that occur as B cells differentiate to antibody secreting plasma cells in response to the T cell independent antigens LPS and NP-Ficoll we performed scRNA-seq. WT or IRF4-deficient B cells were CTV labeled and adoptively transferred into congenically disparate uMT hosts. One day later, the mice were innoculated with LPS and all transferred cells isolated at 72 hours and profiled on the 10x Genomimcs 5' Library Kit. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
8 Samples
Download data: CSV, TSV
Series
Accession:
GSE136376
ID:
200136376
18.

Transcriptome profiling of Blimp-1-deficient B cells from distinct divisions during plasma cell differentiation

(Submitter supplied) To examine the cell division that Blimp-1 functioned during B cell differentiation we adoptively transferred CellTrace Violet labeled Blimp-1-deficient or control B cells into congenically disparate uMT hosts. Following transfer, mice were innoculated with LPS to induce B cell differentiation and 72 hours later cells from distinct divisions were FACS sorted for RNA-seq
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
34 Samples
Download data: CSV
Series
Accession:
GSE136275
ID:
200136275
19.

p38α activation is essential for germinal center B cell to plasma cell differentiation

(Submitter supplied) We report the RNA-seq data of B cell derived from p38αfl/fl and p38αfl/flVavcre mouse in our In vitro plasma cell (iPC) differentiation system.Significantly differential expression analyses show that p38α deficient mainly affects the gene expression at the plasma cell stage.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL21103 GPL24247
20 Samples
Download data: BIGWIG
Series
Accession:
GSE167699
ID:
200167699
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