Similar studies for GEO DataSets (Select 200119262) - GEO DataSets

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Items: 18

Select item 2001192621.

Gene expression profiling of pre-operative mTOR inhibitor everolimus treatment in breast cancer

(Submitter supplied) There is growing evidence that uncontrolled activation of the PI3K/Akt/mTOR pathway contributes to the development and progression of breast cancer. Inhibition of this pathway has antitumour effects in preclinical studies and efficacy in combination with other agents in breast cancer patients. The aim of this study is to characterise the effects of pre-operative everolimus treatment in primary breast cancer patients and to identify potential molecular predictors of response. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6104
88 Samples

Download data: TXT

Series

Accession:: GSE119262

ID:: 200119262

Select item 2000183782.

Gene profiling and prediction of response to anastrozole neoadjuvant treatment in breast cancer

(Submitter supplied) Transcriptome of 17 tru-cut biopsies and 13 matched surgical samples from ER+ breast tumor patients, treated for 3 months with Anastrozole were anayzed to identify a robust expression signature predictive of response to Anastrozole neoadjuvant treatment in ER+ breast cancer patients and, at the same time, to delineate treatment effects.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL6480 GPL6848
60 Samples

Download data: TXT

Series

Accession:: GSE18378

ID:: 200018378

Select item 2000158243.

Gene expression profiling of human gliomas and human glioblastoma cell lines

(Submitter supplied) To identify signaling pathways that are differentially regulated in human gliomas, a microarray analysis on 30 brain tumor samples (12 primary glioblastomas (GBM), 3 secondary glioblastomas (GBM-2), 8 astrocytomas (Astro) and 7 oligodendrogliomas (Oligo)) and on 5 glioblastoma cell lines (LN018, LN215, LN229, LN319 and BS149) was performed. Normal brain tissue (NB) and normal human astrocytes (NHA) were used as a control. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS4467 GDS4468
Platform:: GPL570
45 Samples

Download data: CEL

Series

Accession:: GSE15824

ID:: 200015824

Select item 44684.

Glioblastoma cell lines: LN018, LN215, LN229, LN319 and BS149

Analysis of 5 glioblastoma cell lines (LN018, LN215, LN229, LN319 and BS149). Results provide insight into molecular mechanisms underlying glioblastoma multiforme and other aggressive brain cancers.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 5 cell line sets

Platform:: GPL570
Series:: GSE15824
10 Samples

Download data: CEL

DataSet

Accession:: GDS4468

ID:: 4468

Select item 44675.

Primary and secondary brain tumors: glioblastomas, astrocytomas and oligodendrogliomas

Analysis of primary glioblastomas (GBM), astrocytomas, oligodendrogliomas and secondary GBM brain tumors. MNK1 kinase upregulation observed in primary GBM brain tumors. Results identifiy signaling pathways differentially regulated in gliomas.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 5 cell type, 8 other, 3 tissue sets

Platform:: GPL570
Series:: GSE15824
35 Samples

Download data: CEL

DataSet

Accession:: GDS4467

ID:: 4467

Select item 2001268706.

Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients

(Submitter supplied) Endocrine therapy reduces breast cancer mortality by 40%; but resistance remains a major clinical problem. Identification of gene signatures associated with resistance during endocrine treatment should enable rational therapeutic choices to be made to combat this in individual patients. Here we present an in-depth analysis of global gene-expression that was measured on pairs of core-cut biopsies taken at baseline and at surgery from 254 patients with ER-positive primary breast cancer randomised to receive 2-week’s presurgical AI (n=198) or no presurgical treatment (Control n=56) in the POETIC trial, using changes-in and residual-of the proliferation marker, Ki67 as end-points, to investigate the impact of aromatase inhibitor (AI) therapy on gene expression and identify gene modules representing key biological pathways that relate to early AI-therapy resistance. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
178 Samples

Download data: TXT

Series

Accession:: GSE126870

ID:: 200126870

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000359257.

Calcitriol supplementation effects on Ki67 expression and transcriptional profile of breast cancer specimens from post-menopausal patients

(Submitter supplied) Background: Breast cancer patients present lower 1,25(OH)2D3 or 25(OH)D3 serum levels than unaffected women. Although 1,25(OH)2D3 pharmacological concentrations of 1,25(OH)2D3 may exert antiproliferative effects in breast cancer cell lines, much uncertainty remains about the effects of calcitriol supplementation in tumor specimens in vivo. We have evaluated tumor dimension (ultrassonography), proliferative index (Ki67 expression), 25(OH)D3 serum concentration and gene expression profile, before and after a short term calcitriol supplementation (dose to prevent osteoporosis) to post-menopausal patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
30 Samples

Download data: CEL

Series

Accession:: GSE35925

ID:: 200035925

Select item 2000564938.

Expression data from fine-needle aspiration biopsies of breast cancer metastases from different anatomical sites

(Submitter supplied) To determine whether breast cancer molecular subtypes and tumor characteristics with demonstrated significance in a primary tumor setting can also confer clinically relevant information in breast cancer metastases. We assessed previously published gene expression modules of seven biological processes and the intrinsic subtypes (PAM50). The translational aspect of the Swedish randomized TEX trial included 112 patients with at least one biopsy from morphologically confirmed loco-regional or distant breast cancer metastasis diagnosed from December 2002 until June 2007. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10379
120 Samples

Download data: CEL

Series

Accession:: GSE56493

ID:: 200056493

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000852089.

Expression of oxysterol pathway genes in estrogen positive breast carcinomas

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL19921
203 Samples

Download data

Series

Accession:: GSE85208

ID:: 200085208

Select item 20008520710.

Expression of oxysterol pathway genes in estrogen positive breast carcinomas-first phase

(Submitter supplied) Metabolism of anticancer drugs markedly affects their antitumor effects. The major goal of our study was to investigate associations of gene expression of enzymes metabolizing taxanes and/or anthracyclines with therapy response and survival of breast carcinoma patients The present study investigated differences in transcript levels of key modulators of oxysterol signaling pathway, including oxysterol receptors, metabolic enzymes and transporters in the groups of estrogen receptor positive (ER+) breast carcinomas in comparison to estrogen receptor negative (ER-) ones, and to control non-tumor tissues.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL19921
39 Samples

Download data: TXT

Series

Accession:: GSE85207

ID:: 200085207

Select item 20008520611.

Expression of oxysterol pathway genes in estrogen positive breast carcinomas-second phase

(Submitter supplied) Metabolism of anticancer drugs markedly affects their antitumor effects. The major goal of our study was to investigate associations of gene expression of enzymes metabolizing taxanes and/or anthracyclines with therapy response and survival of breast carcinoma patients The present study investigated transcript levels of key modulators of oxysterol signaling pathway, including oxysterol receptors, metabolic enzymes and transporters in the group of hormone-receptor positive breast carcinoma patients to evaluated potential clinical significance of these genes.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL19921
164 Samples

Download data: TXT

Series

Accession:: GSE85206

ID:: 200085206

Select item 20007323712.

Heterogeneity in global gene expression profiles between biopsy specimens taken peri-surgically from primary ER-positive breast carcinomas

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL6884 GPL10558
158 Samples

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Series

Accession:: GSE73237

ID:: 200073237

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007323613.

Heterogeneity in global gene expression profiles between biopsy specimens taken peri-surgically from primary ER-positive breast carcinomas (excision/x-ray samples)

(Submitter supplied) Gene expression is widely used for the characterization of breast cancers. Variability due to tissue heterogeneity or measurement error or systematic change due to peri-surgical procedures can affect measurements but is poorly documented. We studied the variability of global gene expression between core-cuts of primary ER+ breast cancers and the impact of delays to tissue stabilization due to sample x-ray and of diagnostic core-cutting. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL6884 GPL10558
46 Samples

Download data: TXT

Series

Accession:: GSE73236

ID:: 200073236

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007323514.

Heterogeneity in global gene expression profiles between biopsy specimens taken peri-surgically from primary ER-positive breast carcinomas (diagnostic/surgical samples)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
112 Samples

Download data: TXT

Series

Accession:: GSE73235

ID:: 200073235

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008911615.

Genome wide expression profiles of early and late onset breast cancers

(Submitter supplied) Analysis of breast cancer gene expression profiles. The hypothesis tested in the present study was that if differential profiles exsist between early and late onset breast cancer. Results provide important information regarding up- or down-regulated genes playing a mechanistic role in cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL6947 GPL6884
38 Samples

Download data: TXT

Series

Accession:: GSE89116

ID:: 200089116

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007672816.

Tumour sampling method can significantly influence gene expression profiles derived from neoadjuvant window studies

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
74 Samples

Download data

Series

Accession:: GSE76728

ID:: 200076728

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007672717.

Tumour sampling method can significantly influence gene expression profiles derived from neoadjuvant window studies II

(Submitter supplied) Background: Gene expression profiling has been used extensively within breast cancer research. Patient matched transcriptomic studies of tumour samples before and after treatment offer great potential and have been initiated, but tend not to include a control group. Here we examine gene expression changes between patient-matched core biopsies and surgical resection samples in the absence of treatment, to consider sampling methods and tumour heterogeneity. more...