Similar studies for GEO DataSets (Select 200121720) - GEO DataSets

Select item 2001217201.

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype - tumour rRNA-depleted total ssRNAseq data

(Submitter supplied) Glioblastomas in adult patients are classified into four subtypes, IDH, MES, RTK I, and RTK II, based on DNA-methylation and RNA-expression data. Tumour subtype transitions are common during treatment, and transitions to the mesenchymal (MES) subtype are associated with therapy resistance and adverse prognosis. Here, we present DNA methylome and histone modification data of glioblastoma primary tumours and find that glioblastoma subtypes differ in their enhancer landscapes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
64 Samples

Download data: BIGWIG, CSV, TXT

Series

Accession:: GSE121720

ID:: 200121720

PubMed Full text in PMC Similar studies

Select item 2001455562.

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype - mouse RNAseq experiments

(Submitter supplied) Glioblastomas in adult patients are classified into four subtypes, IDH, MES, RTK I, and RTK II, based on DNA-methylation and RNA-expression data. Tumour subtype transitions are common during treatment, and transitions to the mesenchymal (MES) subtype are associated with therapy resistance and adverse prognosis. Here, we present DNA methylome and histone modification data of glioblastoma primary tumours and find that glioblastoma subtypes differ in their enhancer landscapes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
10 Samples

Download data: CSV

Series

Accession:: GSE145556

ID:: 200145556

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Select item 2001330403.

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype - cell line ATACseq

(Submitter supplied) Glioblastomas in adult patients are classified into four subtypes, IDH, MES, RTK I, and RTK II, based on DNA-methylation and RNA-expression data. Tumour subtype transitions are common during treatment, and transitions to the mesenchymal (MES) subtype are associated with therapy resistance and adverse prognosis. Here, we present DNA methylome and histone modification data of glioblastoma primary tumours and find that glioblastoma subtypes differ in their enhancer landscapes. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
8 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE133040

ID:: 200133040

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Select item 2001217234.

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Expression profiling by array; Methylation profiling by genome tiling array; Methylation profiling by high throughput sequencing

5 related Platforms
364 Samples

Download data: BED, BIGWIG, BW, CEL

Series

Accession:: GSE121723

ID:: 200121723

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Select item 2001217225.

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype - tumour methylation microarray data

(Submitter supplied) Glioblastomas in adult patients are classified into four subtypes, IDH, MES, RTK I, and RTK II, based on DNA-methylation and RNA-expression data. Tumour subtype transitions are common during treatment, and transitions to the mesenchymal (MES) subtype are associated with therapy resistance and adverse prognosis. Here, we present DNA methylome and histone modification data of glioblastoma primary tumours and find that glioblastoma subtypes differ in their enhancer landscapes. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platforms:: GPL13534 GPL23976
60 Samples

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Series

Accession:: GSE121722

ID:: 200121722

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Select item 2001217216.

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype - tumour methylation (WGBS) data

(Submitter supplied) Glioblastomas in adult patients are classified into four subtypes, IDH, MES, RTK I, and RTK II, based on DNA-methylation and RNA-expression data. Tumour subtype transitions are common during treatment, and transitions to the mesenchymal (MES) subtype are associated with therapy resistance and adverse prognosis. Here, we present DNA methylome and histone modification data of glioblastoma primary tumours and find that glioblastoma subtypes differ in their enhancer landscapes. more...

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL11154
64 Samples

Download data: BED, BIGWIG, TXT

Series

Accession:: GSE121721

ID:: 200121721

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Select item 2001217197.

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype - tumour ChIPseq data

(Submitter supplied) Glioblastomas in adult patients are classified into four subtypes, IDH, MES, RTK I, and RTK II, based on DNA-methylation and RNA-expression data. Tumour subtype transitions are common during treatment, and transitions to the mesenchymal (MES) subtype are associated with therapy resistance and adverse prognosis. Here, we present DNA methylome and histone modification data of glioblastoma primary tumours and find that glioblastoma subtypes differ in their enhancer landscapes. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
119 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE121719

ID:: 200121719

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Select item 2001217188.

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype - cell line gene expression microarray data

(Submitter supplied) Glioblastomas in adult patients are classified into four subtypes, IDH, MES, RTK I, and RTK II, based on DNA-methylation and RNA-expression data. Tumour subtype transitions are common during treatment, and transitions to the mesenchymal (MES) subtype are associated with therapy resistance and adverse prognosis. Here, we present DNA methylome and histone modification data of glioblastoma primary tumours and find that glioblastoma subtypes differ in their enhancer landscapes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
15 Samples

Download data: CEL

Series

Accession:: GSE121718

ID:: 200121718

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Select item 2001217179.

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype - cell line RNAseq experiments

(Submitter supplied) Glioblastomas in adult patients are classified into four subtypes, IDH, MES, RTK I, and RTK II, based on DNA-methylation and RNA-expression data. Tumour subtype transitions are common during treatment, and transitions to the mesenchymal (MES) subtype are associated with therapy resistance and adverse prognosis. Here, we present DNA methylome and histone modification data of glioblastoma primary tumours and find that glioblastoma subtypes differ in their enhancer landscapes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
4 Samples

Download data: BIGWIG, TXT

Series

Accession:: GSE121717

ID:: 200121717

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Select item 20012171610.

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype - cell line ChIPseq experiments

(Submitter supplied) Glioblastomas in adult patients are classified into four subtypes, IDH, MES, RTK I, and RTK II, based on DNA-methylation and RNA-expression data. Tumour subtype transitions are common during treatment, and transitions to the mesenchymal (MES) subtype are associated with therapy resistance and adverse prognosis. Here, we present DNA methylome and histone modification data of glioblastoma primary tumours and find that glioblastoma subtypes differ in their enhancer landscapes. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
20 Samples

Download data: BED, BIGWIG, BW

Series

Accession:: GSE121716

ID:: 200121716

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Select item 20013926111.

RNA-seq analysis of in vivo region-specific PDX (G144) tumour cell populations and in vitro SOX10 overexpression in G144 cells

(Submitter supplied) For in vivo experiments GFP+ G144 human GBM cells were injected in the caudoputament of CD-1 nude mice. After tumour formation, GFP+ G144 cells were acultely purified from microdissected mouse brain regions (tumour bulk, corpus callosum, striatum) and sequenced to determine gene expression profiles of the different invasive populations. In vitro G144 cells engineered to express inducible SOX10 vector were exposed to Doxycyline for two days and sequenced to determine gene expression profiles following SOX10 overexpression.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
15 Samples

Download data: CSV

Series

Accession:: GSE139261

ID:: 200139261

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Select item 20012946712.

RNA-seq analysis of SKMEL28 melanoma cells following DIRC3 and IGFBP5 ASO knockdown

(Submitter supplied) We identified genes regulated by the DIRC3 long non-coding RNA and its neighbouring tumour suppressor gene IGFBP5 and determined common targets. DIRC3 and IGFBP5 were knocked down by transient transfection of antisense oligonucleotides (ASOs) in the human melanoma cell line Sk-Mel-28. RNA was extracted 72 hours after transfection and polyA selected 150-bp paired end RNA sequencing was performed on the Illumina HiSeq4000 . more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
9 Samples

Download data: TXT

Series

Accession:: GSE129467

ID:: 200129467

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Select item 20012907813.

The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor

(Submitter supplied) The MITF and SOX10 transcription factors regulate the expression of genes important for melanoma proliferation, invasion and metastasis. Despite growing evidence of the contribution of long non-coding RNAs (lncRNAs) in melanoma and other cancers, their functions within MITF-SOX10 transcriptional programmes is poorly investigated. Here, we identify 245 candidate melanoma associated lncRNAs whose loci are co-occupied by MITF-SOX10 and are enriched at active enhancer-like regions. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
3 Samples

Download data: TXT

Series

Accession:: GSE129078

ID:: 200129078

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Select item 20005787214.

Single cell RNA-seq of primary human glioblastomas

(Submitter supplied) We report transcriptomes from 430 single glioblastoma cells isolated from 5 individual tumors and 102 single cells from gliomasphere cells lines generated using SMART-seq. In addition, we report population RNA-seq from the five tumors as well as RNA-seq from cell lines derived from 3 tumors (MGH26, MGH28, MGH31) cultured under serum free (GSC) and differentiated (DGC) conditions. This dataset highlights intratumoral heterogeneity with regards to the expression of de novo derived transcriptional modules and established subtype classifiers.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
875 Samples

Download data: TXT

Series

Accession:: GSE57872

ID:: 200057872

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Select item 20013183715.

Gene expression profiles of non-recurrent human glioblastoma tissues

(Submitter supplied) Samples were obtained from 52 non-recurrent GBM patients treated at Severance Hospital

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
52 Samples

Download data: IDAT, TXT

Series

Accession:: GSE131837

ID:: 200131837

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Select item 20013309516.

Expression data from PDGF-B and EGFRvIII induced murine gliomas

(Submitter supplied) The trascription profiles of PDGF-B and EGFRvIII induced glioma models were compared. We show that both models converge towards a phenotype that resembles proneural glioblastoma subset.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL, XLSX

Series

Accession:: GSE133095

ID:: 200133095

Select item 20010961417.

RNAseq of murine models of high-grade gliomas induced by overexpression of PDGF-B or EGFRvIII

(Submitter supplied) High grade glioma cells obtained by overexpression of PDGF-B in neural progenitors of Balb/c mice or by overexpression of EGFRvIII in neural progenitors of Ink/Arf -/- Balb/c mice and orthotopically transplanted in adult Balb/c mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23479
7 Samples

Download data: TXT

Series

Accession:: GSE109614

ID:: 200109614

PubMed Similar studies SRA Run Selector

Select item 20014384318.

Methylome analyses of three glioblastoma cohorts reveal chemotherapy sensitivity markers within DDR genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. BACKGROUND: Gliomas evade current therapies through primary and acquired resistance and the effect of temozolomide is mainly restricted to the subgroup of methylguanin-O6-methyltransferase promoter (MGMT) hypermethylated tumors. Further resistance markers and pathways against chemotherapy and radiotherapy are largely unknown and would help for better stratification. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platforms:: GPL13534 GPL21145
315 Samples

Download data: IDAT

Series

Accession:: GSE143843

ID:: 200143843

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Select item 20014384219.

Methylome analyses of three glioblastoma cohorts reveal chemotherapy sensitivity markers within DDR genes [Heidelberg cohort part 2]

(Submitter supplied) The data contains Illumina 450k/EPIC array methylation files from 18 patients with diffuse IDH wild-type glioma from the Heidelberg Neuro-Oncology center