Similar studies for GEO DataSets (Select 200122184) - GEO DataSets

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Items: 20

Select item 2001221841.

Expression Data from Liver of Rats Dosed with Reference Hepatotoxicants (Microarray)

(Submitter supplied) Male Sprague Dawley rats were treated orally for 5 days with reference hepatotoxicants, each at a single dose level alpha-naphthylisothiocyanate 100mg/kg (vehicle 5ml/kg corn oil); carbon tetrachloride 1582mg/kg (vehicle 5ml/kg corn oil); methylenedianiline 100mg/kg (vehicle 35% ethanol); acetaminophen 1000mg/kg (vehicle 2ml/kg corn oil); diclofenac 10mg/kg (vehicle 10ml/kg water)

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL1355
26 Samples

Download data: CEL

Series

Accession:: GSE122184

ID:: 200122184

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Select item 2001223152.

Expression Data from Liver of Rats Dosed with Reference Hepatotoxicants_RNASeq

(Submitter supplied) Male Sprague Dawley rats were treated orally for 5 days with reference hepatotoxicants, each at a single dose level, alpha-naphthylisothiocyanate 100mg/kg (vehicle 5ml/kg corn oil); carbon tetrachloride 1582mg/kg (vehicle 5ml/kg corn oil); methylenedianiline 100mg/kg (vehicle 35% ethanol); acetaminophen 1000mg/kg (vehicle 2ml/kg corn oil); diclofenac 10mg/kg (vehicle 10ml/kg water)

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20084
26 Samples

Download data: TXT

Series

Accession:: GSE122315

ID:: 200122315

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Select item 2000415883.

Expression data for HT29 cells treated with 5-aza-deoxy-cytidine

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL570 GPL11154
18 Samples

Download data: CEL, TXT

Series

Accession:: GSE41588

ID:: 200041588

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Select item 2000415864.

Expression data for HT29 cells treated with 5-aza-deoxy-cytidine [RNA-Seq]

(Submitter supplied) The RNA samples from HT-29 (ATCC) colon cancer cell line were reverse transcribed to build cDNA libraries and categorized into 3 groups with different concentrations of 5-aza-deoxy-cytidine (5-Aza); in each group three replicative 150 mm cultures were treated with: 1) dimethyl sulfoxide (vehicle alone, 0 μM 5-Aza); 2) 5μM 5-Aza and 3) 10 μM 5-Aza; for five days. This experiment was also performed parallel on a commercial Affymetrix microarray [GSE41364] and the aim of the study was to compare the two platforms on gene expression measurements and differentially expressed gene (DEG) detection. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
9 Samples

Download data: TXT

Series

Accession:: GSE41586

ID:: 200041586

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Select item 2000413645.

Expression data for HT29 cells treated with 5-aza-deoxy-cytidine [Affymetrix]

(Submitter supplied) The RNA samples from HT-29 (ATCC) colon cancer cell line were reverse transcribed into cDNAs and categorized in 3 groups with different concentrations of 5-aza-deoxy-cytidine (5-Aza); in each group three replicative 150 mm cultures were treated with: 1) dimethyl sulfoxide (vehicle alone, 0 μM 5-Aza); 2) 5μM 5-Aza and 3) 10 μM 5-Aza; for five days We then used Affymetrix microarray platform to profile the gene expression of the 3 HT29 cell groups (3 replicates in each group) in order to search for differentially expressed genes

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
9 Samples

Download data: CEL

Series

Accession:: GSE41364

ID:: 200041364

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Select item 2000212106.

Comparing next-generation sequencing and microarray technologies in a toxicological study of the effects of aristolochic Acid on rat kidneys

(Submitter supplied) RNA-Seq has been increasingly used for the quantification and characterization of transcriptomes. The ongoing development of the technology promises the more accurate measurement of gene expression. However, its benefits over widely accepted microarray technologies have not been adequately assessed, especially in toxicogenomics studies. The goal of this study is to enhance the scientific community's understanding of the advantages and challenges of RNA-Seq in the quantification of gene expression by comparing analysis results from RNA-Seq and microarray data on a toxicogenomics study. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10287
8 Samples

Download data: TXT

Series

Accession:: GSE21210

ID:: 200021210

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Select item 2000538617.

Whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat, at different sequencing depths

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL6543 GPL10669 GPL6194
30 Samples

Download data: CEL

Series

Accession:: GSE53861

ID:: 200053861

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Select item 2000538608.

Whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat, at different sequencing depths (Affymetrix exon-level)

(Submitter supplied) RNA derived from the L5 DRG 7 days following L5-SNT and from naïve L5-DRG tissue was subjected to microarray analysis and expression was determined at the exon and gene level

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL6194
6 Samples

Download data: CEL

Series

Accession:: GSE53860

ID:: 200053860

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Select item 2000537649.

Whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat, at different sequencing depths (Affymetrix transcript-level)

(Submitter supplied) RNA derived from the L5 DRG 7 days following L5-SNT and from naïve L5-DRG tissue was subjected to microarray analysis and expression was determined at the exon and gene level

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL6543
6 Samples

Download data: CEL

Series

Accession:: GSE53764

ID:: 200053764

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Select item 20005376210.

Whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat, at different sequencing depths (RNA-Seq)

(Submitter supplied) Poly(A) enriched RNA derived from the L5 DRG 7 days following L5-SNT and from naïve L5-DRG tissue was subjected to RNA-seq analysis at different sequencing depths

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10669
18 Samples

Download data: TXT

Series

Accession:: GSE53762

ID:: 200053762

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Select item 20011895611.

TempO-Seq S1500+ Platform Gene Expression of Rat Liver Mode of Action Samples

(Submitter supplied) Using the TempO-Seq rat S1500+ platform we performed gene expression analysis of using 63 purified RNA samples from the livers of rats exposed to controls or chemicals that fall into one of five modes of action (MOAs): constitutive androstane receptor/pregnane X receptor (CAR/PXR) activation, aryl hydrocarbon receptor (AhR) activation, peroxisome proliferator-activated receptor-alpha (PPARA) activation, cytotoxicity or DNA damage. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25029
63 Samples

Download data: TXT

Series

Accession:: GSE118956

ID:: 200118956

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Select item 20005534712.

SEQC Toxicogenomics Study: RNA-Seq data set

(Submitter supplied) The comparative advantages of RNA-Seq and microarrays in transcriptome profiling were evaluated in the context of a comprehensive study design. Gene expression data from Illumina RNA-Seq and Affymetrix microarrays were obtained from livers of rats exposed to 27 agents that comprised of seven modes of action (MOAs); they were split into training and test sets and verified with real time PCR.

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL14844 GPL17116
116 Samples

Download data: PDF, TXT

Series

Accession:: GSE55347

ID:: 200055347

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Select item 20004787513.

SEQC Toxicogenomics Study: microarray data set

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL1355
105 Samples

Download data: CEL

Series

Accession:: GSE47875

ID:: 200047875

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Select item 20004589214.

Temporal Concordance between Apical and Transcriptional Points-of-Departure for Chemical Risk Assessment

(Submitter supplied) The number of legacy chemicals without toxicity reference values combined with the rate of new chemical development are overwhelming the capacity of the traditional risk assessment paradigm. More efficient approaches are needed to quantitatively estimate chemical risks. In this study, rats were dosed orally with multiple doses of six chemicals for 5 days, 2, 4, and 13 weeks. Target organs were analyzed for traditional histological and organ weight changes and transcriptional changes using microarrays. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL16985
720 Samples

Download data: CEL

Series

Accession:: GSE45892

ID:: 200045892

Select item 20004897815.

Comparison of RNA-Seq and Microarray in Transcriptome Profiling During T Cell Activation

(Submitter supplied) Samples in this study probe the gene expression kinetics in human CCR6+ Th17 memory T cells activated under Th17 condition. Human CCR6+ Th17 memory T cells were purified from PBMC and gene expression was studied over a time course of 3 days after activation under Th17 condition. RNA from these samples was also profiled using RNA-Seq to compare different transcriptome profiling technologies.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
12 Samples

Download data: CEL

Series

Accession:: GSE48978

ID:: 200048978

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Select item 20005657616.

p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo

(Submitter supplied) The goal of the present study was to compare hepatic toxicogenomic signatures across in vitro and in vivo mouse models following exposure to acetaminophen (APAP) or its relatively nontoxic regioisomer 3'-hydroxyacetanilide (AMAP). Two different Affymetrix microarray platforms and one Agilent Oligonucleotide microarray were utilized. APAP and AMAP treatments resulted in significant and large changes in gene expression that were quite disparate, and likely related to their different toxicologic profiles. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
9 Samples

Download data: CEL

Series

Accession:: GSE56576

ID:: 200056576

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Select item 20009239817.

RNA-Seq transcriptomics and pathway analyses reveal potential regulatory genes and molecular mechanisms in high- and low-feed efficient Nordic dairy cattle

(Submitter supplied) The study investigated gene expression patterns in liver tissue to understand the biological functions of genes that are potentially involved in controlling / regulating feed efficiency in Nordic dairy cattle.

Organism:: Bos taurus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19172
38 Samples

Download data: TXT

Series

Accession:: GSE92398

ID:: 200092398

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Select item 20008478818.

Compared performance of Affymetrix HTA arrays and Illumina RNAseq for the analysis of tumours

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL17585
36 Samples

Download data: CEL

Series

Accession:: GSE84788

ID:: 200084788

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Select item 20008478419.

Compared performance of Affymetrix HTA arrays and Illumina RNAseq for the analysis of tumours [Affymetrix]

(Submitter supplied) Here we compared the performance of Affymetrix HTA 2.0 microarray and Illumina 2000 RNA-sequencing techniques on the clinical samples collected from patients with lung squamous cell carcinoma.