GEO DataSets

(Submitter supplied) Modeling molecular changes in breast cancer with naturally occurring canine mammary tumors and cross-organism analysis enables resolution of malignancy-specific processes.

Organism:

Canis lupus familiaris

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16540

89 Samples

Download data: CSV, TXT

(Submitter supplied) Using microarray technology, we aim to identify genes affecting the biology of mammary tumor cancers in dogs. Canine mammary gland tumors (CMGTs) are the most common neoplasms in sexually intact female dogs. CMGTs have been suggested as a model for studying human breast cancer because of several similarities, including the relative age of onset, risk factors, incidence, histological and molecular features, biological behavior, metastatic pattern, and responses to therapy.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL13605

22 Samples

Download data: TXT

(Submitter supplied) [original title] Metastatic Canine Mammary Carcinomas can be Identified by a Gene Expression Profile that partly Overlaps with Human Breast Cancer Profiles. Introduction: Similar to human breast cancer mammary tumors of the female dog are commonly associated with a fatal outcome due to the development of distant metastases. However, the molecular defects leading to metastasis are largely unknown and the value of canine mammary carcinoma as a model for human breast cancer is unclear. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

27 Samples

Download data: CEL

(Submitter supplied) Spontaneous tumors in dog have been demonstrated to share many features with their human counterparts, including relevant molecular targets, histological appearance, genetics, biological behavior and response to conventional treatments. Mammary tumors in dog therefore provide an attractive alternative to more classical mouse models, such as transgenics or xenografts, where the tumour is artificially induced. more...

Organism:

Homo sapiens; Canis lupus familiaris

Type:

Expression profiling by array

Platforms:

GPL7198 GPL3991

162 Samples

Download data

(Submitter supplied) Cancer-associated stroma (CAS) and matched normal stroma (NS) samples from 13 cases of canine mammary adenoma

Organism:

Canis lupus familiaris

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24229

26 Samples

Download data: CSV

(Submitter supplied) Cancer-associated stroma (CAS) and matched normal stroma (NS) samples from 15 cases of canine mammary carcinoma (mCA).

Organism:

Canis lupus familiaris

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24229

30 Samples

Download data: CSV

(Submitter supplied) Background: Research using in vitro canine mammary carcinoma cell lines and studies involving naturally occurring canine mammary tumours are not only fundamental models used to advance the understanding of cancer in veterinary patients but are also regarded as excellent translational models for human breast cancer. In human medicine, following disease classification and staging breast cancer is typically treated with multimodal therapies including radiotherapy. more...

Organism:

Canis lupus familiaris; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28490

10 Samples

Download data: TXT