Similar studies for GEO DataSets (Select 200149998) - GEO DataSets

(Submitter supplied) To evaluate the potential of EphB3 as a therapeutic target during CNS inflammation, we induced EAE in B6 WT mice and starting at the peak of the disease we initiated treatment with A38 administered. A38 administration ameliorated EAE, and the transcriptional analysis of the astrocytes and microglia revealed the decreased expression of genes associated to inflammation and neurodegeneration.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
24 Samples

Download data: TXT

Series

Accession:: GSE149135

ID:: 200149135

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014910712.

Astrocytes and microglia establish physical interactions during CNS inflammation

(Submitter supplied) To investigate astrocyte-microglia interactions in vivo, we took advantage of the recombinant rabies virus (RV). We used glycoprotein G-deficient RV expressing the fluorescent protein mCherry and pseudotyped with glycoprotein EnvA, in combination with GFAP-Cre RABVgp4/TVA transgenic mice that express TVA protein and glycoprotein G in astrocytes under the control of the Gfap promoter. Following injection into GfapRABVgp4/TVA mice, RV initially infects TVA expressing astrocytes, and following its replication RV infect cells in direct contact with astrocytes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: ZIP

Series

Accession:: GSE149107

ID:: 200149107

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Select item 20014910513.

Pharmacologic or genetic inhibition of EphB3 receptor kinase impacts CNS pathology during progressive EAE

(Submitter supplied) We evaluated the role of EphB3 on the regulation of astrocyte and microglial responses and its potential as a therapeutic target during progressive EAE. We induced EAE in NOD mice that will develop a progressive form of the disease. Starting at the beginning of the progressive phase, A38 was administered and alternatively EphB3 was KD in astrocytes. Both treatments ameliorated the EAE. The transcriptional analysis of astrocytes and microglia revealed the decreased expression of genes associated to inflammation and neurodegeneration in both conditions.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
32 Samples

Download data: ZIP

Series

Accession:: GSE149105

ID:: 200149105

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Select item 20014905214.

Eph Receptor B3/EphrinB3 signaling impact CNS pathology during EAE

(Submitter supplied) We aimed to investigate the role of EphB3 and EfnB3 on the regulation of astrocyte and microglial responses in the context of CNS inflammation, we KD Efnb3 in microglia or EphB3 in astrocytes both resulting in a comparable amelioration of EAE. The transcriptional analysis of the two cell types revealed the decreased expression of genes associated to inflammation and neurodegeneration in both KD conditions.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
24 Samples

Download data: TXT

Series

Accession:: GSE149052

ID:: 200149052

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Select item 20013731415.

Genome-wide analysis of the transcriptional profile of IL1b/TNFa-treated and EAE astrocytes in B6 mice.

(Submitter supplied) We identify pathways regulated by IL1b/TNFa ICV injection and EAE in astrocytes

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: TXT

Series

Accession:: GSE137314

ID:: 200137314

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Select item 20013557116.

Genome-wide analysis of the transcriptional profile of WT and Mafg KD astrocytes during EAE in B6 mice.

(Submitter supplied) We identify pathways regulated by Mafg in astrocytes during EAE

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: TXT

Series

Accession:: GSE135571

ID:: 200135571

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Select item 20013011917.

MAFG-driven astrocytes promote CNS inflammation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing

5 related Platforms
163 Samples

Download data: BEDGRAPH, CSV, TXT

Series

Accession:: GSE130119

ID:: 200130119

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Select item 20013011818.

Genome-wide analysis of the transcriptional profile of astrocytes across EAE by CNS region in Gfap-Cre;Ribotag(f/f) mice uisng Ribotag immunoprecipitation.

(Submitter supplied) We identify pathways regulated in astrocytes across EAE by CNS region. Multiple sclerosis (MS) is an autoimmune neurologic disease leading to demyelination and neurologic dysfunction controlled by both genetic and environmental factors. In addition to CNS-infiltrating immune cells, CNS-resident cells, such as astrocytes, are thought to play an important role in MS pathogenesis. However, a comprehensive understanding of the extent to which gene expression is disrupted in astrocytes is not known. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
40 Samples

Download data: TXT

Series

Accession:: GSE130118

ID:: 200130118

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Select item 20013010519.

Genome-wide analysis of the transcriptional profile of the CNS in healthy control patients.

(Submitter supplied) Multiple sclerosis (MS) is an autoimmune neurologic disease leading to demyelination and neurologic dysfunction controlled by both genetic and environmental factors. In addition to CNS-infiltrating immune cells, CNS-resident cells, such as astrocytes, are thought to play an important role in MS pathogenesis. However, a comprehensive understanding of the extent to which gene expression is disrupted in astrocytes is not known. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL20301
5 Samples

Download data: CSV, TXT

Series

Accession:: GSE130105

ID:: 200130105

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012977420.

Genome-wide analysis of the transcriptional profile of WT and Nfe2l2 KD astrocytes during EAE in B6 mice [Nrf2 RNA-seq]

(Submitter supplied) We identify pathways regulated by Nfe2l2 in astrocytes during EAE Multiple sclerosis (MS) is an autoimmune neurologic disease leading to demyelination and neurologic dysfunction controlled by both genetic and environmental factors. In addition to CNS-infiltrating immune cells, CNS-resident cells, such as astrocytes, are thought to play an important role in MS pathogenesis. However, a comprehensive understanding of the extent to which gene expression is disrupted in astrocytes is not known. more...