GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:

GPL10123 GPL4091 GPL6244

137 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) We analyzed 100 patient samples by high-resolution arrayCGH to study genomic imbalances in ACC.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platforms:

GPL4091 GPL10123

100 Samples

Download data: TXT

(Submitter supplied) This experiment investigates global gene expression in adenoid cystic carcinoma (30) and normal salivary gland tissue (7).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

37 Samples

Download data: CEL, CHP

(Submitter supplied) Using high-resolution, array-based comparative genomic hybridization (aCGH), we explored genomic alterations in 40 fresh-frozen ACC samples, the largest cohort to date, with the aims to: (1) identify recurrent CNAs in ACC; (2) identify novel candidate target genes; and (3) correlate recurrent CNAs with tumour grade and other clinical parameters to identify potential clinically useful biomarkers.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL4091

40 Samples

Download data: TXT

(Submitter supplied) This experiment investigates differences in global gene expression between ACC and NSG.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

22 Samples

Download data: CEL, CHP

(Submitter supplied) The MYB-NFIB gene is a driver-mutation in the majority of adenoid cystic carcinomas (ACCs) and believed to control a large number of genes involved in tumorigenesis. This experiment investigates the effects on gene expression after siRNA knock-down of MYB-NFIB and/or inhibition of IGF1R/INSR signaling in ACC cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

18 Samples

Download data: CEL, CHP

(Submitter supplied) Salivary gland adenoid cystic carcinoma (ACC) is a rare malignancy with limited treatment options. The development of novel therapies is hindered by a lack of preclinical models. We have generated several ACC patient-derived xenograft (PDX) lines that retain the physical and genetic properties of the original tumours, including the presence of the common MYB/MYBL1-NFIB translocation. Using these PDXs, we have developed the conditions for the generation of 2D and 3D ACC models that retain MYB expression and can be used for drug studies. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30173

6 Samples

Download data: TSV