Similar studies for GEO DataSets (Select 200158583) - GEO DataSets

(Submitter supplied) AXL is activated by its ligand GAS6 and is expressed in triple-negative breast cancer cells. We report that AXL is also detected in HER2+ breast cancer specimens where its expression correlates with poor patients’ survival. Using murine models of HER2+ breast cancer, AXL, but not Gas6, was found essential for metastasis. We determined that AXL is required for intravasation, extravasation and growth at the metastatic site. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: TXT

Series

Accession:: GSE102369

ID:: 200102369

PubMed Similar studies SRA Run Selector

Select item 2001023684.

RNA-seq of MMTV-Neu AXL KO tumors

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: TXT, XLSX

Series

Accession:: GSE102368

ID:: 200102368

PubMed Similar studies SRA Run Selector

Select item 2001851105.

Transcriptomic analysis of orthotopic pancreatic tumors treated by Axl inhibitor TP-0903 or combination with chemo/immunotherapy using the nCounter PanCancer Immune Profiling panel (Nanostring Technologies) [mouse]

(Submitter supplied) RNA isolated from KPfC orthotopic tumors was analyzed using Mouse PanCancer Immune Profiling Panel (NanoString Technologies).

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL30298
36 Samples

Download data: CSV, RCC

Series

Accession:: GSE185110

ID:: 200185110

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000178026.

The role of vimentin in regulating genes related to EMT

(Submitter supplied) To study the biological and functional role of vimentin in maintenance of the mesenchymal phenotype of mammary epithelial cells, vimentin was silenced in the non-transformed MCF10A cells and vimentin-dependent changes in gene expression were analyzed.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6106
4 Samples

Download data: TXT

Series

Accession:: GSE17802

ID:: 200017802

Select item 2000330727.

An epithelial-mesenchymal transition (EMT) gene signature predicts resistance to erlotinib and PI3K pathway inhibitors and identifies Axl as a novel EMT marker in non-small cell lung cancer.

(Submitter supplied) Epithelial/mesenchymal transition (EMT) is associated with loss of cell adhesion molecules, such as E-cadherin, and increased invasion, migration, and proliferation in epithelial cancers. In non-small cell lung cancer (NSCLC), EMT is associated with greater resistance to EGFR inhibitors. However, its potential to predict response to other targeted drugs or chemotherapy has not been well characterized. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
131 Samples

Download data: CEL

Series

Accession:: GSE33072

ID:: 200033072

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000329898.

Expression profiling of lung cancer cell lines (UTSW Lung Panel V2)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13376
69 Samples

Download data: TXT

Series

Accession:: GSE32989

ID:: 200032989

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000320369.

Expression profiling of lung cancer cell lines

(Submitter supplied) Purpose: To determine the 8-week disease control rate (DCR) of sorafenib monotherapy in patients with advanced non-small-cell lung cancer (NSCLC) in the BATTLE trial. Methods: Patients with pre-treated NSCLC, ECOG performance status (PS) 0-2, consented to biopsies to test for biomarker assessment. Sorafenib was given at 400 mg orally twice daily until tumor progression or an unacceptable toxicity. Tumor evaluations were performed at baseline and every 8 weeks. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL10558 GPL6884
222 Samples

Download data: TXT

Series

Accession:: GSE32036

ID:: 200032036

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007654010.

Expression data from MCF-7 and MCF-7/ADR cells

(Submitter supplied) Chemoresistance in breast cancer has been a great interest in past studies, however, the development of rational therapeutic strategies targeting chemoresistant cells is still a challenge for clinical oncology.The resistant property of MCF7/ADR cells was confirmed by long term culture with Dox, cell viability, and PARP cleavage assays. Microarray analysis was performed to compare the global differences of gene expression between MCF-7 and MCF-7/ADR cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE76540

ID:: 200076540

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002183411.

Identification of the receptor tyrosine kinase AXL in triple negative breast cancer as a novel target for the human miR-34a microRNA

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus; Homo sapiens; Mus musculus

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL5106 GPL570
21 Samples

Download data: CEL, GPR

Series

Accession:: GSE21834

ID:: 200021834

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002183212.

Identification of the receptor tyrosine kinase AXL in triple negative breast cancer as a novel target for the human miR-34a microRNA (gene expression)

(Submitter supplied) Triple negative breast cancer (TNBC) is histologically characterized by the absence of the hormone receptors estrogen and progesterone, in addition to having a negative immunostain for HER-2. The aggressiveness of this disease and lack of targeted therapeutic options for treatment is of high clinical importance. MicroRNAs are short 21- to 23 nucleotide endogenous non-coding RNAs that regulate gene expression by binding to mRNA transcripts, resulting in either decreased protein translation or mRNA degradation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
9 Samples

Download data: CEL

Series

Accession:: GSE21832

ID:: 200021832

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002171913.

Identification of the receptor tyrosine kinase AXL in triple negative breast cancer as a novel target for the human miR-34a microRNA (miRNA study)

Organism:: Rattus norvegicus; Homo sapiens; Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL5106
12 Samples

Download data: GPR

Series

Accession:: GSE21719

ID:: 200021719

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006355814.

Mesenchymal cancer cell-stromal crosstalk promotes niche activation, epithelial reversion and metastatic colonization

(Submitter supplied) The experiment was design to address the intrinsic differences between metastatic cancer stem cells in the primary tumour and during metastatic colonization in the mouse mammary gland tumour model MMTV-pyMT.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
3 Samples

Download data: TXT

Series

Accession:: GSE63558

ID:: 200063558

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20019017615.

Differential gene expression in MCF10A cells upon stable co-upregulation of flotillins 1 and 2

(Submitter supplied) The simultaneous overexpression of flotillins 1 and 2 is observed in many cancers and considered as a marker of poor prognosis, notably in breast cancer. Flotillin-overexpression was shown to participate in the invasive behavior of cancer cell leading to metastasis. To better characterize the specific contribution of flotillin upregulation in the acquisition of cellular invasive properties, we stably expressed at high level exogenous flotillin 1 (HA-tagged) and flotillin 2 (mCherry tagged) in the non-tumoral mammary epithelial MCF10A human cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
6 Samples

Download data: CSV

Series

Accession:: GSE190176

ID:: 200190176

Select item 20019925716.

RNA sequencing of CD19-directed chimeric antigen receptor T (CART19) cells with and without TP-0903 treatment

(Submitter supplied) TP-0903 was obtained from Tolero Pharmaceuticals. CART19 cells from five biological replicates were thawed and stimulated with irradiated Jeko-1 cells (120 Gy) for 5 days. Jeko-1 is a human mantle cell lymphoma cell line that expresses the CD19 antigen (ATCC). Each sample was treated with either 30 nM TP0903 (treated condition) or DMSO (untreated control). CART19 were isolated to a purity of 100% using CD19 microbeads (Miltenyi). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
10 Samples

Download data: CSV, TXT

Series

Accession:: GSE199257

ID:: 200199257

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20021713217.

Effects of PFKFB4 deletion on transcriptional reprogramming in breast cancer cells

(Submitter supplied) To explore the mechanisms by which PFKFB4 promotes breast cancer metastasis, we CRISPR-Cas knock-out PFKFB4 in two breast cancer lines for RNA-seq to identify downstream target genes that are regulated by PFKFB4